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Literature summary for 3.4.22.60 extracted from

  • Cassidy, S.K.; Hagar, J.A.; Kanneganti, T.D.; Franchi, L.; Nunez, G.; ORiordan, M.X.
    Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response (2012), PLoS Pathog., 8, e1002628.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
caspase 1 caspase-7 is cleaved and activated by caspase-1. This is mediated by flagellin and requires the host receptors Nlrc4 and Naip5 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Mus musculus
-

General Information

General Information Comment Organism
malfunction mice lacking caspase-7 and its macrophages allow substantial Legionella pneumophila replication. This permissiveness of caspase-7-deficient macrophages to the intracellular pathogen is due to defective delivery of the organism to the lysosome and to delayed cell death during early stages of infection Mus musculus
physiological function caspase-7 plays a role in host defense against Legionella pneumophila. Caspase-7 activation during Legionella pneumophila infection restricts growth by promoting early macrophage death and efficient delivery of the organism to the lysosome Mus musculus