Activating Compound | Comment | Organism | Structure |
---|---|---|---|
caspase 1 | caspase-7 is cleaved and activated by caspase-1. This is mediated by flagellin and requires the host receptors Nlrc4 and Naip5 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
malfunction | mice lacking caspase-7 and its macrophages allow substantial Legionella pneumophila replication. This permissiveness of caspase-7-deficient macrophages to the intracellular pathogen is due to defective delivery of the organism to the lysosome and to delayed cell death during early stages of infection | Mus musculus |
physiological function | caspase-7 plays a role in host defense against Legionella pneumophila. Caspase-7 activation during Legionella pneumophila infection restricts growth by promoting early macrophage death and efficient delivery of the organism to the lysosome | Mus musculus |