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Information on EC 3.4.13.23 - cysteinylglycine-S-conjugate dipeptidase

for references in articles please use BRENDA:EC3.4.13.23
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.13 Dipeptidases
                3.4.13.23 cysteinylglycine-S-conjugate dipeptidase
IUBMB Comments
The enzyme participates in a widespread glutathione-mediated detoxification pathway. In animals the activity is usually catalysed by enzymes that have numerous additional activities, such as EC 3.4.11.1, leucyl aminopeptidase, EC 3.4.11.2, membrane alanyl aminopeptidase, and EC 3.4.13.19, membrane dipeptidase. However, in the bacterium Corynebacterium sp. Ax20, which degrades axillary secretions, the enzyme appears to be specific for this task.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
Synonyms
BLH1, cytosolic aminopeptidase, lap3, thiol precursor dipeptidase, tpdA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an [L-cysteinylglycine]-S-conjugate + H2O = an L-cysteine-S-conjugate + glycine
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