Literature summary for 3.4.13.23 extracted from

Joesch, C.; Klotz, L.; Sies, H.
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver (2003), Biol. Chem., 384, 213-218 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
bestatin	0.1 mM, 90% inhibition	Rattus norvegicus
o-phenanthroline	0.1 mM, 50% inihibition	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q68FS4	cf. ECs 3.4.11.1, 3.4.11.5	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.54	-	substrate bimane S-cysteinylglycine, pH not specified in the publication, temperature not specified in the publication	Rattus norvegicus
1.6	-	substrate cysteinylglycine, pH not specified in the publication, temperature not specified in the publication	Rattus norvegicus
63.6	-	substrate cystinyl-bis-glycine, pH not specified in the publication, temperature not specified in the publication	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
bimane S-cysteinylglycine + H2O	-	Rattus norvegicus	bimane S-cysteine + glycine	-	?
cysteinylglycine + H2O	-	Rattus norvegicus	cysteine + glycine	-	?
cystinyl-bis-glycine + H2O	-	Rattus norvegicus	? + glycine	-	?

Synonyms

Synonyms	Comment	Organism
cytosolic aminopeptidase	-	Rattus norvegicus
lap3	-	Rattus norvegicus

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Release 2023.1 (January 2023)