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Information on EC 3.13.1.9 - S-inosyl-L-homocysteine hydrolase

for references in articles please use BRENDA:EC3.13.1.9
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IUBMB Comments
The enzyme, characterized from the methanogenic archaeon Methanocaldococcus jannaschii, binds an NAD+ cofactor. It participates in an alternative pathway for the regeneration of S-adenosyl-L-methionine from S-adenosyl-L-homocysteine that involves the deamination of the latter to S-inosyl-L-homocysteine.
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The enzyme appears in viruses and cellular organisms
Synonyms
MJ1388, SIHH, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-inosyl-L-homocysteine + H2O = inosine + L-homocysteine
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