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Information on EC 3.13.1.9 - S-inosyl-L-homocysteine hydrolase

for references in articles please use BRENDA:EC3.13.1.9

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IUBMB Comments

The enzyme, characterized from the methanogenic archaeon Methanocaldococcus jannaschii, binds an NAD+ cofactor. It participates in an alternative pathway for the regeneration of S-adenosyl-L-methionine from S-adenosyl-L-homocysteine that involves the deamination of the latter to S-inosyl-L-homocysteine.

The enzyme appears in viruses and cellular organisms

Synonyms
s-inosyl-l-homocysteine hydrolase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-inosyl-L-homocysteine + H2O = inosine + L-homocysteine
show the reaction diagram
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