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Information on EC 3.1.4.38 - glycerophosphocholine cholinephosphodiesterase and Organism(s) Mus musculus and UniProt Accession Q8BGN3

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IUBMB Comments
No activity on sn-3-glycerophosphoethanolamine.
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This record set is specific for:
Mus musculus
UNIPROT: Q8BGN3
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
glycerophosphocholine cholinephosphodiesterase, gpc-cpde, glycerophosphocholine choline phosphodiesterase, gpc-cp, l-3-glycerylphosphinicocholine cholinephosphohydrolase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ectonucleotide pyrophosphatase/phosphodiesterase family member 6
-
Co2+-glycerophosphocholine cholinphosphodiesterase
-
-
-
-
L-3-glycerylphosphinicocholine cholinephosphohydrolase
-
-
-
-
p-nitrophenylphosphocholine cholinphosphodiesterase
-
-
-
-
Zn2+-glycerophosphocholine cholinphosphodiesterase
-
-
-
-
Zn2+-GPC cholinphosphodiesterase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
sn-glycero-3-phosphocholine cholinephosphohydrolase
No activity on sn-3-glycerophosphoethanolamine.
CAS REGISTRY NUMBER
COMMENTARY hide
60063-78-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
sn-glycero-3-phosphocholine + H2O
glycerol + phosphocholine
show the reaction diagram
p-nitrophenylphosphocholine + H2O
p-nitrophenol + choline phosphate
show the reaction diagram
sn-glycero-3-phosphocholine + H2O
glycerol + choline phosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
sn-glycero-3-phosphocholine + H2O
glycerol + phosphocholine
show the reaction diagram
the choline moiety of glycero-3-phosphocholine is incorporated into phosphocholine in an ENPP6-dependent manner both in vivo and in vitro
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
-
no enzyme activity with prior incubation
tellurium tetrachloride
-
potent competitive inhibitor
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0055
p-nitrophenylphosphocholine
-
Zn2+ is required for maximum activity
0.048
sn-glycero-3-phosphocholine
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0007 - 0.0015
tellurium tetrachloride
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
9 - 11
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Swissprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
high expression in liver sinusoidal endothelial cells
Manually annotated by BRENDA team
high expression
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
22-34% of activity
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
ENPP6-deficient mice exhibit fatty liver and hypomyelination
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ENPP6_MOUSE
440
0
50618
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
170000
-
gel filtration
74000
-
SDS-PAGE
75000
-
gel filtration
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
structure of ENPP6 in complex with phosphocholine. The choline moiety of the phosphocholine is recognized by a choline-binding pocket formed by conserved aromatic and acidic residues
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35 - 50
-
90% loss of activity at 50oC
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sok D.E.; Kim, M.R.
Characterization of a Zn(2+)-requiring glycerophosphocholine cholinephosphodiesterase possessing p-nitrophenylphosphocholine phosphodiesterase activity
Biochem. J.
286
435-440
1992
Mus musculus
Manually annotated by BRENDA team
Sok D.E.; Kim, M.R.
Brain myelin-bound Zn(2+)-glycerophosphocholine cholinephosphodiesterase is a glycosylphosphatidylinositol-anchored enzyme of two different molecular forms
Neurochem. Res.
19
97-103
1994
Mus musculus
Manually annotated by BRENDA team
Sok, D.E.; Kim, M.R.
Selective inhibition of Zn2+-glycerophosphocholine cholinephosphodiesterase by tellurium tetrachloride
Biochem. J.
284
641-643
1992
Mus musculus
-
Manually annotated by BRENDA team
Morita, J.; Kano, K.; Kato, K.; Takita, H.; Sakagami, H.; Yamamoto, Y.; Mihara, E.; Ueda, H.; Sato, T.; Tokuyama, H.; Arai, H.; Asou, H.; Takagi, J.; Ishitani, R.; Nishimasu, H.; Nureki, O.; Aoki, J.
Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase
Sci. Rep.
6
20995
2016
Mus musculus (Q8BGN3)
Manually annotated by BRENDA team