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Literature summary for 3.1.4.38 extracted from

  • Morita, J.; Kano, K.; Kato, K.; Takita, H.; Sakagami, H.; Yamamoto, Y.; Mihara, E.; Ueda, H.; Sato, T.; Tokuyama, H.; Arai, H.; Asou, H.; Takagi, J.; Ishitani, R.; Nishimasu, H.; Nureki, O.; Aoki, J.
    Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase (2016), Sci. Rep., 6, 20995 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
structure of ENPP6 in complex with phosphocholine. The choline moiety of the phosphocholine is recognized by a choline-binding pocket formed by conserved aromatic and acidic residues Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sn-glycero-3-phosphocholine + H2O Mus musculus the choline moiety of glycero-3-phosphocholine is incorporated into phosphocholine in an ENPP6-dependent manner both in vivo and in vitro glycerol + phosphocholine
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?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BGN3
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-

Source Tissue

Source Tissue Comment Organism Textmining
liver high expression in liver sinusoidal endothelial cells Mus musculus
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oligodendrocyte high expression Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sn-glycero-3-phosphocholine + H2O
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Mus musculus glycerol + phosphocholine
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?
sn-glycero-3-phosphocholine + H2O the choline moiety of glycero-3-phosphocholine is incorporated into phosphocholine in an ENPP6-dependent manner both in vivo and in vitro Mus musculus glycerol + phosphocholine
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?

Synonyms

Synonyms Comment Organism
ectonucleotide pyrophosphatase/phosphodiesterase family member 6
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Mus musculus
ENPP6
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Mus musculus

General Information

General Information Comment Organism
physiological function ENPP6-deficient mice exhibit fatty liver and hypomyelination Mus musculus