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Information on EC 3.1.3.62 - multiple inositol-polyphosphate phosphatase and Organism(s) Mus musculus and UniProt Accession Q9Z2L6

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IUBMB Comments
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
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This record set is specific for:
Mus musculus
UNIPROT: Q9Z2L6
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
multiple inositol-polyphosphate phosphatase, (mmu)minpp1, (hsa)minpp1, taphyiia2, taphyiib, inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase, hvphyiib, hvphyiia2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
(MMU)Minpp1
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1D-myo-inositol-1,3,4,5-tetrakisphosphate 3-phosphohydrolase
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-
-
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inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
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-
-
-
inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase
-
-
-
-
inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase
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-
-
-
inositol tetrakisphosphate phosphomonoesterase
-
-
-
-
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase
-
-
-
-
Minpp
-
-
-
-
MIPP
-
-
-
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phosphatase, inositol 1,3,4,5-tetrakisphosphate 3-
-
-
-
-
additional information
distinct group within the histidine phosphatase family
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
1D-myo-inositol-hexakisphosphate 5-phosphohydrolase
This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.
CAS REGISTRY NUMBER
COMMENTARY hide
116958-30-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
show the reaction diagram
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
show the reaction diagram
-
-
-
?
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
D-myo-inositol 1,4,5-trisphosphate + phosphate
show the reaction diagram
inositol 1,3,4,5,6-pentakisphosphate + H2O
inositol 1,4,5,6-tetrakisphosphate + phosphate
show the reaction diagram
-
-
-
-
?
inositol hexakisphosphate + H2O
inositol pentakisphosphate + phosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
Minpp is important to chondrocyte differentiation in a manner independent of inositol polyphosphate turnover
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
Mg2+-independent
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
not inhibited by digitonin
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
assay at
7.4
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
assay at
37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
(MMU)Minpp1
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
mRNA expression
Manually annotated by BRENDA team
mRNA expression
Manually annotated by BRENDA team
mRNA expression
Manually annotated by BRENDA team
highest mRNA expression
Manually annotated by BRENDA team
mRNA expression
Manually annotated by BRENDA team
mRNA expression
Manually annotated by BRENDA team
mRNA expression
Manually annotated by BRENDA team
mRNA expression
Manually annotated by BRENDA team
mRNA expression
Manually annotated by BRENDA team
mRNA expression
Manually annotated by BRENDA team
-
chondrocyte progenitor cell line, developmentally specific changes in MINPP expression
Manually annotated by BRENDA team
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lymphoma cell line
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MINP1_MOUSE
481
0
54537
Swiss-Prot
Mitochondrion (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
54500
x * 54500, inclusive the putative signal sequence, amino acid sequence analysis
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 54500, inclusive the putative signal sequence, amino acid sequence analysis
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
0°C, 10 mM Tris-HCl, pH 7.4, 100 mM KCl, 1 mM dithiothreitol, up to 1 month, stable
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant (MMU)Minpp1 fusion protein expressed in Escherichia coli JM109
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
sequenced and expressed in Escherichia coli JM109, located on chromosome 19, genomic organization
MINPP gene encoding multiple inositol polyphosphate phosphatase
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cullen, P.J.; Irvine, R.F.; Drobak, B.K.; Dawson, A.P.
Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate
Biochem. J.
259
931-933
1989
Mus musculus
Manually annotated by BRENDA team
Hidaka, K.; Kanematsu, T.; Caffrey, J.J.; Takeuchi, H.; Shears, S.B.; Hirata, M.
The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase
Exp. Cell Res.
290
254-264
2003
Homo sapiens, Mus musculus, Oryctolagus cuniculus
Manually annotated by BRENDA team
Chi, H.; Tiller, G.E.; Dasouki, M.J.; Romano, P.R.; Wang, J.; O'Keefe, R.J.; Puzas, J.E.; Rosier, R.N.; Reynolds, P.R.
Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19
Genomics
56
324-336
1999
Homo sapiens (Q9UNW1), Homo sapiens, Mus musculus (Q9Z2L6), Mus musculus
Manually annotated by BRENDA team