Any feedback?
Literature summary for 3.1.3.62 extracted from
- Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19 (1999), Genomics, 56, 324-336.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| located on chromosome 10q23, genomic organization | Homo sapiens |
| sequenced and expressed in Escherichia coli JM109, located on chromosome 19, genomic organization | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mutant with active site histidine altered to alanine has abolished enzyme activity | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 54500 | - |
x * 54500, inclusive the putative signal sequence, amino acid sequence analysis | Mus musculus |
| 55100 | - |
x * 55100, inclusive the putative signal sequence, amino acid sequence analysis | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UNW1 | (HSA)MINPP1 | - |
| Mus musculus | Q9Z2L6 | (MMU)Minpp1 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant (MMU)Minpp1 fusion protein expressed in Escherichia coli JM109 | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | mRNA expression | Mus musculus | - |
| chondrocyte | fetal growth plate cartilage, mRNA expression | Homo sapiens | - |
| heart | mRNA expression | Mus musculus | - |
| HeLa cell | mRNA expression | Homo sapiens | - |
| intestine | mRNA expression | Mus musculus | - |
| kidney | highest mRNA expression | Mus musculus | - |
| liver | mRNA expression | Mus musculus | - |
| lung | mRNA expression | Mus musculus | - |
| additional information | tissue distribution of (MMU)Minpp1 mRNA | Mus musculus | - |
| skin | mRNA expression | Mus musculus | - |
| spleen | mRNA expression | Mus musculus | - |
| testis | mRNA expression | Mus musculus | - |
| thymus | mRNA expression | Mus musculus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0°C, 10 mM Tris-HCl, pH 7.4, 100 mM KCl, 1 mM dithiothreitol, up to 1 month, stable | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl phosphate + H2O | - |
Mus musculus | 4-nitrophenol + phosphate | - |
? |  |
| D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | - |
Mus musculus | D-myo-inositol 1,4,5-trisphosphate + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 54500, inclusive the putative signal sequence, amino acid sequence analysis | Mus musculus |
| ? | x * 55100, inclusive the putative signal sequence, amino acid sequence analysis | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| (HSA)MINPP1 | - |
Homo sapiens |
| (MMU)Minpp1 | - |
Mus musculus |
| More | distinct group within the histidine phosphatase family | Homo sapiens |
| More | distinct group within the histidine phosphatase family | Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
