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acyl CoA hydrolase
-
-
-
-
acyl coenzyme A hydrolase
-
-
-
-
acyl coenzyme A thioesterase
-
-
-
-
acyl-CoA thioesterase 11
-
-
acyl-CoA thioesterase 13
-
-
acyl-CoA thioesterase Acot12
-
-
acyl-CoA thioesterase Acot8
-
-
acyl-CoA thioesterase-2
-
-
fatty acyl thioesterase I
-
-
-
-
HIV-Nef associated acyl coA thioesterase
-
-
-
-
hydrolase, acyl coenzyme A
-
-
-
-
hydrolase, palmitoyl coenzyme A
-
-
-
-
long chain acyl-CoA hydrolase
-
-
-
-
long chain acyl-CoA thioesterase
-
-
-
-
long chain fatty-acyl-CoA hydrolase
-
-
-
-
long chain fatty-acyl-CoA thioesterase
-
-
-
-
long-chain acyl-CoA hydrolase
-
-
mitochondrial acyl-CoA thioesterase
-
-
-
-
palmitoyl coenzyme A hydrolase
-
-
-
-
palmitoyl thioesterase
-
-
-
-
palmitoyl-CoA deacylase
-
-
-
-
palmitoyl-CoA hydrolase
-
-
-
-
palmityl coenzyme A deacylase
-
-
-
-
palmityl thioesterase
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-
-
-
palmityl thioesterase I
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-
-
-
palmityl thioesterase II
-
-
-
-
thioesterase superfamily member 2
-
-
very long chain acyl-CoA thioesterase
-
-
-
-
Acot7
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-
Acot7
-
cytosolic isoform
acyl-CoA thioesterase
-
-
-
-
acyl-CoA thioesterase
-
-
brain acyl-CoA hydrolase
-
-
-
-
brain acyl-CoA hydrolase
-
-
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2-methylstearoyl-CoA + H2O
CoA + 2-methylstearate
-
-
-
?
2-trans-decenoyl-CoA + H2O
CoA + 2-trans-decenoate
-
-
-
?
3-hydroxy-3-methyl glutaryl-CoA + H2O
CoA + 3-hydroxy-3-methyl glutarate
-
-
-
?
3-hydroxyhexadecanoyl-CoA + H2O
CoA + 3-hydroxyhexadecanoate
-
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
-
-
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
long-chain fatty-acyl-CoA
-
-
?
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
?
arachidoyl-CoA + H2O
CoA + arachidate
-
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholoate
choloyl-CoA + H2O
CoA + choloate
clofibroyl-CoA + H2O
CoA + clofibrate
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
dodecanoyl-CoA + H2O
CoA + dodecanoate
-
-
-
?
hexadecanoyl-CoA + H2O
CoA + hexadecanoate
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
?
n-butyryl-CoA + H2O
CoA + n-butanoate
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
octanoyl-CoA + H2O
CoA + octanoate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
?
propionyl-CoA + H2O
CoA + propionate
-
-
-
?
prostaglandin F2alpha-CoA + H2O
prostaglandin F2alpha + CoA
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
trihydroxycoprostanoyl-CoA + H2O
CoA + trihydroxycoprostanoate
-
-
-
?
2-butenoyl-CoA + H2O
CoA + 2-butenoate
-
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
-
-
-
-
?
3-hydroxybutyryl-CoA + H2O
CoA + 3-hydroxybutyrate
-
-
-
-
?
acetyl-CoA + H2O
CoA + acetate
-
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
arachidonoyl-CoA + H2O
CoA + arachidonate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
DL-3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
-
-
-
-
?
DL-3-hydroxybutyryl-CoA + H2O
?
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
lauroyl-CoA + H2O
CoA + laurate
-
-
-
-
?
lauroyl-CoA + H2O
CoA + lauroate
-
-
-
-
?
linolenoyl-CoA + H2O
CoA + linolenoate
-
-
-
-
?
linoleoyl-CoA + H2O
CoA + linoleate
-
-
-
-
?
malonyl-CoA + H2O
CoA + malonate
-
-
-
-
?
myristoyl-CoA + H2O
CoA + myristate
-
-
-
-
?
octadecanoyl-CoA + H2O
CoA + octadecanoate
-
-
-
?
oleoyl-CoA + H2O
CoA + oleate
-
-
-
-
?
palmitoleoyl-CoA + H2O
CoA + palmitoleoate
-
-
-
-
?
palmitoyl-CoA + H2O
CoA + palmitate
-
-
-
-
?
phenylacetyl-CoA + H2O
CoA + phenylacetate
-
-
-
-
?
stearoyl-CoA + H2O
CoA + stearate
-
-
-
-
?
tetradecanoyl-CoA + H2O
CoA + tetradecanoate
-
-
-
?
additional information
?
-
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholoate
activity is PPARalpha-inducible
-
-
?
chenodeoxycholoyl-CoA + H2O
CoA + chenodeoxycholoate
bile acid derivative substrate
-
-
?
choloyl-CoA + H2O
CoA + choloate
activity is PPARalpha-inducible
-
-
?
choloyl-CoA + H2O
CoA + choloate
bile acid derivative substrate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
involved in fatty acid metabolism
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
-
?
decanoyl-CoA + H2O
CoA + decanoate
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
-
?
hexanoyl-CoA + H2O
CoA + hexanoate
-
-
-
?
additional information
?
-
-
enzyme regulation
-
-
?
additional information
?
-
-
enzyme regulation by dietary manipulation
-
-
?
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0.0069
-
substrate 3-hydroxy-3-methylglutaryl-CoA
0.014
-
substrate malonyl-CoA
0.0298
-
substrate hexanoyl-CoA
0.0304
-
substrate myristoyl-CoA, at 25°C
0.0322
-
substrate myristoyl-CoA, at 37°C, in the presence of small unilamellar vesicles composed of phosphatidylcholine at 4 mM total phospholipid concentration
0.0377
-
substrate lauroyl-CoA
0.0381
-
substrate palmitoyl-CoA
0.0454
-
substrate 3-hydroxybutyryl-CoA
0.0469
-
substrate myristoyl-CoA, at 37°C
0.0543
-
substrate decanoyl-CoA
0.0568
-
substrate palmitoyl-CoA, in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 0.5
0.0604
-
substrate oleoyl-CoA
0.0614
-
substrate myristoyl-CoA, at 50°C
0.0652
-
substrate palmitoyl-CoA, in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 1.0
0.0681
-
substrate myristoyl-CoA, at 37°C, in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 0.5
0.0846
-
substrate myristoyl-CoA, at 37°C, in the presence of StarD2 protein in a molar ratio StarD2/Them2 of 1.0
0.1198
-
substrate phenylacetyl-CoA
additional information
-
in mesenteric lymph nodes of mice fasted for 16 h, ACOT7 levels are induced 1.8fold, which reflect a 1.5fold increase in enzyme activity
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metabolism
-
Acot2 enhances mitochondrial fatty acid oxidation
physiological function
doubling cytosolic enzyme activity fails to protect mice from diet-induced obesity, fatty liver or insulin resistance, however, overexpression of isoform Acot7 in adipocytes renders mice cold intolerant
malfunction
-
ACOT7 knockout mice in the nervous system, reveal increased fatty acid flux into multiple long-chain acyl-CoA-dependent pathways. The alterations in brain fatty acid metabolism are concomitant with a loss of lean mass, hypermetabolism, hepatic steatosis, dyslipidemia, and behavioral hyperexcitability in Acot7 N-/- mice
malfunction
-
Ad-Acot2 mice have higher free fatty acid utilization during the rest phase of the day but readily switch to carbohydrate oxidation at night. In isolated Ad-Acot2 liver mitochondria, phosphorylating O2 consumption is elevated with lipid but not non-lipid substrate. While the monolysocardiolipin pool in expanded in Ad-Acot2 liver mitochondria, total cardiolipin is unchanged
malfunction
-
Them5 knockout mice display changes in the lipid profile of cardiolipin and its metabolites. Them5 loss results in an 2fold decrease in free fatty acids in mitochondria, with a particularly marked decrease in linoleic and linolenic acids in the knockout samples. Them5 knockout mice develop fatty liver. In addition, loss of thioesterase activity of Them5 leads to changes in mitochondrial morphology and function
malfunction
-
Them5-/- mice show deregulation of lipid metabolism and the development of fatty liver, exacerbated by a high-fat diet. Mitochondrial morphology is affected, and functions such as respiration and beta-oxidation are impaired
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Poupon, V.; Begue, B.; Gagnon, J.; Dautry-Varsat, A.; Cerf-Bensussan, N.; Benmerah, A.
Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase
J. Biol. Chem.
274
19188-19194
1999
Arabidopsis thaliana, Bacillus subtilis, Caenorhabditis elegans, Drosophila melanogaster, Escherichia coli, Haemophilus influenzae, Helicobacter pylori, Homo sapiens, Mus musculus (Q9R0X4), Oryctolagus cuniculus, Rattus norvegicus
brenda
Hunt, M.C.; Lindquist, P.J.G.; Peters, J.M.; Gonzalez, F.J.; Diczfalusy, U.; Alexson, S.E.H.
Involvement of the peroxisome proliferator-activated receptor a in regulating long-chain acyl-CoA thioesterases
J. Lipid Res.
41
814-823
2000
Mus musculus
brenda
Hunt, M.C.; Solaas, K.; Kase, B.F.; Alexson, S.E.
Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism
J. Biol. Chem.
277
1128-1138
2002
Mus musculus (P58137)
brenda
Hunt, M.; Lindquist, P.J.G.; Nousiainen, S.; Svensson, T.L.T.; Diczfalusy, U.; Alexson, S.E.H.
Cloning and regulation of peroxisome proliferator-induced acyl-CoA thioesterases from mouse liver
Adv. Exp. Med. Biol.
466
195-200
1999
Mus musculus
brenda
Takagi, M.; Ohtomo, T.; Hiratsuka, K.; Kuramochi, Y.; Suga, T.; Yamada, J.
Localization of a long-chain acyl-CoA hydrolase in spermatogenic cells in mice
Arch. Biochem. Biophys.
446
161-166
2006
Mus musculus
brenda
Golovko, M.Y.; Rosenberger, T.A.; Faergeman, N.J.; Feddersen, S.; Cole, N.B.; Pribill, I.; Berger, J.; Nussbaum, R.L.; Murphy, E.J.
Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism
Biochemistry
45
6956-6966
2006
Mus musculus
brenda
Westin, M.A.; Hunt, M.C.; Alexson, S.E.
Short- and medium-chain carnitine acyltransferases and acyl-CoA thioesterases in mouse provide complementary systems for transport of beta-oxidation products out of peroxisomes
Cell. Mol. Life Sci.
65
982-990
2008
Mus musculus
brenda
Wei, J.; Kang, H.W.; Cohen, D.E.
Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs
Biochem. J.
421
311-322
2009
Mus musculus
brenda
Ohtomo, T.; Nakao, C.; Sumiya, M.; Kaminuma, O.; Abe, A.; Mori, A.; Inaba, N.; Kato, T.; Yamada, J.
Identification of acyl-CoA thioesterase in mouse mesenteric lymph nodes
Biol. Pharm. Bull.
36
866-871
2013
Mus musculus
brenda
Han, S.; Cohen, D.E.
Functional characterization of thioesterase superfamily member 1/Acyl-CoA thioesterase 11: implications for metabolic regulation
J. Lipid Res.
53
2620-2631
2012
Mus musculus
brenda
Moffat, C.; Bhatia, L.; Nguyen, T.; Lynch, P.; Wang, M.; Wang, D.; Ilkayeva, O.R.; Han, X.; Hirschey, M.D.; Claypool, S.M.; Seifert, E.L.
Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver
J. Lipid Res.
55; 2458-2470
2458-2470
2014
Mus musculus
brenda
Zhuravleva, E.; Gut, H.; Hynx, D.; Marcellin, D.; Bleck, C.K.; Genoud, C.; Cron, P.; Keusch, J.J.; Dummler, B.; Esposti, M.D.; Hemmings, B.A.
Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development
Mol. Cell. Biol.
32
2685-2697
2012
Mus musculus, Homo sapiens (Q5T1C6)
brenda
Ellis, J.M.; Wong, G.W.; Wolfgang, M.J.
Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity
Mol. Cell. Biol.
33
1869-1882
2013
Mus musculus
brenda
Ellis, J.M.; Bowman, C.E.; Wolfgang, M.J.
Metabolic and tissue-specific regulation of acyl-CoA metabolism
PLoS ONE
10
e0116587
2015
Mus musculus (Q8VHQ9), Mus musculus (Q91V12)
brenda