Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed as a GST-fusion protein in Escherichia coli | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | thioesterase domain alone of Them1 is sufficient to yield active recombinant protein, START domain is required for optimal enzyme activity | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Mus musculus | |
CoASH | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0075 | - |
palmitoyl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0079 | - |
lauroyl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0081 | - |
myristoyl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0093 | - |
linoleoyl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0128 | - |
oleoyl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0133 | - |
Arachidonoyl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0136 | - |
palmitoleoyl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0232 | - |
malonyl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0279 | - |
stearoyl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0479 | - |
DL-3-hydroxybutyryl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0481 | - |
acetyl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0498 | - |
phenylacetyl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0682 | - |
2-butenoyl-CoA | pH 7.5, 37°C | Mus musculus | |
0.0868 | - |
DL-3-hydroxy-3-methylglutaryl-CoA | pH 7.5, 37°C | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | concentrated to the greatest extent in liver | Mus musculus | 5737 | - |
microsome | concentrated to the greatest extent in brown adipose tissue | Mus musculus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
112000 | - |
FPLC | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
affinity chromatography | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brown adipose tissue | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-butenoyl-CoA + H2O | - |
Mus musculus | CoA + 2-butenoate | - |
? | |
acetyl-CoA + H2O | - |
Mus musculus | CoA + acetate | - |
? | |
arachidonoyl-CoA + H2O | - |
Mus musculus | CoA + arachidonate | - |
? | |
DL-3-hydroxy-3-methylglutaryl-CoA + H2O | - |
Mus musculus | CoA + 3-hydroxy-3-methylglutarate | - |
? | |
DL-3-hydroxybutyryl-CoA + H2O | - |
Mus musculus | ? | - |
? | |
lauroyl-CoA + H2O | - |
Mus musculus | CoA + lauroate | - |
? | |
linoleoyl-CoA + H2O | - |
Mus musculus | CoA + linoleate | - |
? | |
malonyl-CoA + H2O | - |
Mus musculus | CoA + malonate | - |
? | |
myristoyl-CoA + H2O | - |
Mus musculus | CoA + myristate | - |
? | |
oleoyl-CoA + H2O | - |
Mus musculus | CoA + oleate | - |
? | |
palmitoleoyl-CoA + H2O | - |
Mus musculus | CoA + palmitoleoate | - |
? | |
palmitoyl-CoA + H2O | - |
Mus musculus | CoA + palmitate | - |
? | |
phenylacetyl-CoA + H2O | - |
Mus musculus | CoA + phenylacetate | - |
? | |
stearoyl-CoA + H2O | - |
Mus musculus | CoA + stearate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
acyl-CoA thioesterase 11 | - |
Mus musculus |
StarD14 | - |
Mus musculus |
Them1 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.2 | - |
Arachidonoyl-CoA | pH 7.5, 37°C | Mus musculus | |
2.3 | - |
stearoyl-CoA | pH 7.5, 37°C | Mus musculus | |
2.7 | - |
linoleoyl-CoA | pH 7.5, 37°C | Mus musculus | |
3.2 | - |
oleoyl-CoA | pH 7.5, 37°C | Mus musculus | |
3.2 | - |
phenylacetyl-CoA | pH 7.5, 37°C | Mus musculus | |
4.7 | - |
myristoyl-CoA | pH 7.5, 37°C | Mus musculus | |
4.7 | - |
palmitoleoyl-CoA | pH 7.5, 37°C | Mus musculus | |
5.3 | - |
lauroyl-CoA | pH 7.5, 37°C | Mus musculus | |
8.5 | - |
palmitoyl-CoA | pH 7.5, 37°C | Mus musculus | |
9.6 | - |
malonyl-CoA | pH 7.5, 37°C | Mus musculus | |
11 | - |
2-butenoyl-CoA | pH 7.5, 37°C | Mus musculus | |
12 | - |
DL-3-hydroxy-3-methylglutaryl-CoA | pH 7.5, 37°C | Mus musculus | |
13 | - |
DL-3-hydroxybutyryl-CoA | pH 7.5, 37°C | Mus musculus | |
24 | - |
acetyl-CoA | pH 7.5, 37°C | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |