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Information on EC 3.1.1.80 - acetylajmaline esterase

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.80 acetylajmaline esterase
IUBMB Comments
This plant enzyme is responsible for the last stages in the biosynthesis of the indole alkaloid ajmaline. The enzyme is highly specific for the substrates 17-O-acetylajmaline and 17-O-acetylnorajmaline as the structurally related acetylated alkaloids vinorine, vomilenine, 1,2-dihydrovomilenine and 1,2-dihydroraucaffricine cannot act as substrates . This is a novel member of the GDSL family of serine esterases/lipases.
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The enzyme appears in viruses and cellular organisms
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
17-O-acetylajmaline + H2O = ajmaline + acetate
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17-O-acetylnorajmaline + H2O = norajmaline + acetate
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