Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 2.8.1.11 - molybdopterin synthase sulfurtransferase

for references in articles please use BRENDA:EC2.8.1.11

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of EC 2.8.1.12, molybdopterin synthase. In the human, the reaction is catalysed by the rhodanese-like C-terminal domain (cf. EC 2.8.1.1) of the MOCS3 protein, a bifunctional protein that also contains EC 2.7.7.80, molybdopterin-synthase adenylyltransferase, at the N-terminal domain.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
molybdenum cofactor biosynthesis protein, mocs3-rld, mocs3 rhodanese-like domain, molybdopterin synthase sulfurylase, molybdopterin synthase sulfurase, cnxf protein, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine + reduced acceptor = AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + [cysteine desulfurase]-L-cysteine + oxidized acceptor
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
-
-
Highest Expressing Human Cell Lines
Cell Line Links Gene Links