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Results 1 - 3 of 3

EC Number	Natural Substrates	Commentary (Nat. Sub.)
2.8.1.11	more	MOCS3 activates both MOCS2A and URM1 by adenylation and a subsequent sulfur transfer step for the formation of the thiocarboxylate group at the C-terminus of each protein The sulfur is mobilized from L-cysteine by NFS1, a pyridoxal phosphate-dependent L-cysteine desulfurase, which forms a persulfide group on its conserved Cys-381 residue. The persulfide group is further transferred to Cys-412 of the C-terminal rhodanese-like domain of MOCS3
2.8.1.11	more	MOCS3 catalyzes both the adenylation and the subsequent generation of a thiocarboxylate group at the C-terminus of MOCS2A during Moco biosynthesis in humans. In humans and most eukaryotes thiosulfate is not the physiologic sulfur donor for MOCS3
2.8.1.11	[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine	-

Results 1 - 3 of 3

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Release 2023.1 (January 2023)