Information on EC 2.7.8.3 - ceramide cholinephosphotransferase

for references in articles please use BRENDA:EC2.7.8.3
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:

The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.7.8.3
-
RECOMMENDED NAME
GeneOntology No.
ceramide cholinephosphotransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CDP-choline + a ceramide = CMP + sphingomyelin
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
substituted phospho group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Sphingolipid metabolism
-
-
Metabolic pathways
-
-
SYSTEMATIC NAME
IUBMB Comments
CDP-choline:N-acylsphingosine cholinephosphotransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9026-14-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
guinea pig
-
-
Manually annotated by BRENDA team
chicken
-
-
Manually annotated by BRENDA team
hamster, BHK 21 baby hamster kidney cells, ATCC CCL10
-
-
Manually annotated by BRENDA team
mouse
-
-
Manually annotated by BRENDA team
Sprague-Dawley
-
-
Manually annotated by BRENDA team
pig
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cytidine diphosphate choline + ceramide
CMP + sphingomyelin
show the reaction diagram
cytidine diphosphate choline + N-acetyl-DL-threo-1,3-dihydroxy-2-amino-octadecyne
CMP + sphingomyelin
show the reaction diagram
-
-
-
-
?
cytidine diphosphate choline + N-acetyl-DL-threo-trans-sphingosine
CMP + sphingomyelin
show the reaction diagram
cytidine diphosphate choline + N-acyl-threo-trans-sphingosine
CMP + sphingomyelin
show the reaction diagram
cytidine diphosphate choline + N-octanoyl-DL-threo-1,3-dihydroxy-2-amino-octadecyne
CMP + sphingomyelin
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
cytidine diphosphate choline + N-acyl-threo-trans-sphingosine
CMP + sphingomyelin
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
activates to a lesser extent than Mn2+
Mn2+
-
required for optimum activity
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 7.5
7.5 - 8
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7 - 8.5
-
about 50% of activity maximum at pH 7.0, about 45% of activity maximum at pH 8.5
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25 - 55
-
about 60% of activity maximum at 25°C, about 70% of activity maximum at 55°C
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE