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Ligand sphingomyelin

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

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Show Natural Substrate (10 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.12

a sphingomyelin + H2O = a ceramide + choline phosphate

714689, 716445, 716252, 714335

-

3.1.4.12

a sphingomyelin + H2O = a ceramide + phosphocholine

729609, 730731, 729101, 730294, 730879, 729131, 729132, 729171, 730073, 730227, 730694, 730356

-

3.1.4.12

sphingomyelin + H2O = ?

135167, 135162, 135146, 135147, 135148, 135149, 135150, 135153, 135156, 135159, 135160, 135161, 135168, 135169, 135187, 135155, 135163, 135165, 135170, 135171, 135172, 135173, 135157, 135166

-

3.1.4.12

sphingomyelin + H2O = ceramide + phosphocholine

750265, 750288, 750737, 751105, 751328, 751655

-

3.1.4.12

sphingomyelin + H2O = ceramide + phosphorylcholine

750751

-

3.1.4.12

sphingomyelin + H2O = N-acylsphingosine + choline phosphate

652079, 651148, 651338, 652444, 652543, 653119, 677875, 678939, 679682, 679685, 680745, 680767, 681259, 681266, 681322, 650323, 651315, 652706, 653103, 653120, 678083, 680065, 652090, 652972, 678819, 650366, 650502, 650584, 651801, 652701, 649984, 649682, 649563, 652601, 652461, 678957, 653652, 652373, 652974, 651708, 664859, 664590, 664216, 664837, 682477, 677602, 681268, 679649, 680754, 679082, 680143, 678250, 677818, 682983, 663974, 678142, 678375, 679604, 681689, 682246, 680063, 677878, 679144

-

3.1.4.12

6 entries

3.1.4.3

sphingomyelin + H2O = ceramide + phosphorylcholine

135299, 135292

-

3.1.4.41

sphingomyelin + H2O = ceramide 1-phosphate + choline

714926, 752304, 750196, 751183, 751246, 728914

-

3.1.4.41

sphingomyelin + H2O = ceramide phosphate + choline

730746, 750742, 730697, 731005, 751216, 751945, 751580, 752317, 752303, 752308

-

3.1.4.41

sphingomyelin + H2O = choline + ceramide 1-phosphate

666380

-

3.1.4.41

3 entries

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

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Show Natural Product (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.8.27

a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol

0

-

2.7.8.27

ceramide + phosphatidylcholine = sphingomyelin + 1,2-diacyl-sn-glycerol

0

-

2.7.8.27

phosphatidylcholine + ceramide = sphingomyelin + 1,2-diacyl-sn-glycerol

0

-

2.7.8.27

phosphatidylcholine + ceramide = sphingomyelin + diacylglycerol

0

-

2.7.8.27

4 entries

2.7.8.3

cytidine diphosphate choline + N-acyl-threo-trans-sphingosine = CMP + sphingomyelin

0

-

Substrate in Enzyme-catalyzed Reactions (22 results)

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Show Substrate (22 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.8.27

sphingomyelin + diacylglycerol = ceramide + phosphatidylcholine

668587

-

3.1.1.32

sphingomyelin + H2O = ?

690664

-

3.1.1.5

sphingomyelin + H2O = ?

663943

-

3.1.4.12

a sphingomyelin + H2O = a ceramide + choline phosphate

714052, 714689, 716445, 716252, 714410, 714335

-

3.1.4.12

a sphingomyelin + H2O = a ceramide + phosphocholine

729609, 730731, 729101, 730294, 730356, 730879, 729131, 729132, 729171, 730073, 730227, 730694, 730060

-

3.1.4.12

sphingomyelin + H2O = ?

135167, 135162, 135146, 135147, 135148, 135149, 135150, 135153, 135156, 135159, 135160, 135161, 135168, 135169, 135187, 135155, 135163, 135165, 135170, 135171, 135172, 135173, 135157, 135166

-

3.1.4.12

sphingomyelin + H2O = ceramide + phosphocholine

750264, 750265, 750288, 750737, 751105, 751328, 751655, 751793

-

3.1.4.12

sphingomyelin + H2O = ceramide + phosphorylcholine

750751, 751069

-

3.1.4.12

sphingomyelin + H2O = N-acylsphingosine + choline phosphate

135167, 678142, 135188, 652079, 678375, 679649, 680063, 680143, 690455, 691696, 692073, 693467, 693810, 694904, 701641, 135146, 135147, 135149, 135151, 135152, 135153, 135156, 135168, 135178, 135179, 135180, 135184, 135186, 135187, 651148, 651338, 652444, 652543, 653119, 663974, 664216, 677818, 677875, 678250, 678939, 679144, 679604, 679682, 679685, 680745, 680754, 680767, 681259, 681266, 681322, 682246, 682477, 682983, 691060, 691456, 692009, 692236, 692274, 694111, 694201, 694260, 694284, 705457, 705473, 135163, 135170, 135171, 135183, 650323, 651315, 652706, 652974, 653103, 653120, 678083, 680065, 681268, 702696, 703199, 135181, 652090, 652972, 677602, 690659, 690667, 705258, 677878, 135182, 703595, 690903, 651708, 678819, 135166, 650366, 650502, 650584, 651801, 652701, 664590, 664837, 681689, 693938, 704040, 649984, 649682, 664217, 649563, 652601, 652461, 678957, 653652, 652373, 666743, 693160, 704668, 665711, 665716, 135172, 135173, 135158, 704743, 664859, 664187, 664262, 679082

-

3.1.4.3

sphingomyelin + H2O = ceramide + phosphocholine

652656, 749975

-

3.1.4.3

sphingomyelin + H2O = ceramide + phosphorylcholine

135286, 135297, 662891, 133931, 135299, 135308, 135296, 135298, 135292, 135307, 681794, 661980, 678414

-

3.1.4.3

sphingomyelin + H2O = N-acylsphingosine + choline phosphate

715836, 714335

-

3.1.4.12

6 entries

3.1.4.3

3 entries

3.1.4.4

sphingomyelin + H2O = N-acylsphingosylphosphate + choline

135445, 135435, 135434, 135456, 678469

-

3.1.4.41

sphingomyelin + H2O = ceramide 1-phosphate + choline

714926, 752304, 750196, 751183, 751246, 728914, 716964

-

3.1.4.41

sphingomyelin + H2O = ceramide phosphate + choline

653121, 652708, 730746, 750742, 730697, 731005, 751216, 751945, 650896, 694095, 751580, 752317, 690391, 706849, 695217, 752303, 752308

-

3.1.4.41

sphingomyelin + H2O = ceramide-1-phosphate + choline

666380, 681249, 691130

-

3.1.4.41

sphingomyelin + H2O = choline + ceramide 1-phosphate

666380, 665610

-

3.1.4.41

sphingomyelin + H2O = choline + ceramide phosphate

652516, 663894, 666985

-

3.1.4.41

sphingomyelin + H2O = N-acylsphingosylphosphate + choline

135483, 135485, 135478, 135479, 135481, 135486, 135480, 135482, 135487, 135484

-

3.1.4.41

6 entries

3.5.1.69

sphingomyelin + H2O = ?

288938, 754363

-

7.6.2.1

ATP + H2O + sphingomyelin/out = ADP + phosphate + sphingomyelin/in

697594

-

7.6.2.1

ATP + H2O + sphingomyelin[side 1] = ADP + phosphate + sphingomyelin[side 2]

749181

-

7.6.2.1

2 entries

Product in Enzyme-catalyzed Reactions (11 results)

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Show Product (11 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.8.27

a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol

0

-

2.7.8.27

ceramide + phosphatidylcholine = sphingomyelin + 1,2-diacyl-sn-glycerol

0

-

2.7.8.27

phosphatidylcholine + ceramide = sphingomyelin + 1,2-diacyl-sn-glycerol

0

-

2.7.8.27

phosphatidylcholine + ceramide = sphingomyelin + diacylglycerol

0

-

2.7.8.3

cytidine diphosphate choline + ceramide = CMP + sphingomyelin

0

-

2.7.8.3

cytidine diphosphate choline + N-acetyl-DL-threo-1,3-dihydroxy-2-amino-octadecyne = CMP + sphingomyelin

0

-

2.7.8.3

cytidine diphosphate choline + N-acetyl-DL-threo-trans-sphingosine = CMP + sphingomyelin

0

-

2.7.8.3

cytidine diphosphate choline + N-acyl-threo-trans-sphingosine = CMP + sphingomyelin

0

-

2.7.8.3

cytidine diphosphate choline + N-octanoyl-DL-threo-1,3-dihydroxy-2-amino-octadecyne = CMP + sphingomyelin

0

-

7.6.2.1

ATP + H2O + sphingomyelin/out = ADP + phosphate + sphingomyelin/in

0

-

7.6.2.1

ATP + H2O + sphingomyelin[side 1] = ADP + phosphate + sphingomyelin[side 2]

0

-

2.7.8.27

4 entries

2.7.8.3

5 entries

7.6.2.1

2 entries

Activator in Enzyme-catalyzed Reactions (13 results)

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Show Activating Compound (13 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.13.11.63

stimulates

438227

-

2.3.1.22

0.0025-0.0075 mM, activates

486606

-

2.3.1.22

stimulates

486608

-

2.3.1.22

2 entries

2.4.1.17

almost indispensable activator of GlcAT-P as to glycoprotein acceptors

660431

-

2.4.1.83

activates

489438

-

2.4.1.88

activation

489482

-

2.7.1.107

activation of phospholipids in the order of decreasing efficiency: phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin

640370

-

2.7.7.41

stimulates

643311

-

3.1.1.2

stimulates

646527

-

3.1.1.4

activates hydrolysis of phosphatidylethanolamine

133906

-

3.1.3.51

activates

134915

-

3.1.4.12

dietary sphingomyelin increases the alk-Smase activity in the colon by 65%, the increased activity is associated with increased protein and mRNA expression

690455

-

3.1.6.8

inhibition or activation depends on substrate

135676

-

Inhibitor in Enzyme-catalyzed Reactions (19 results)

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Show Inhibitors (19 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.26

-

486677

-

2.3.1.43

-

487010, 703346

-

2.3.1.43

physiologic inhibitor, ceramide protects partially

672155

-

2.3.1.43

2 entries

2.7.1.94

inhibition alone, synergistic activation with the protein peak eluted from hydroxylapatite by 25 mM phosphate

642127

-

2.7.7.15

causes inhibition when present in multilamellar vesicles

642915

-

2.8.2.20

weak

645807

-

3.1.1.4

-

751182

-

3.1.1.4

suppresses the activating effect of oxidized palmitoyl arachidonyl phosphatidylcholine in a dose-dependent manner, abolishing it almost completely at a concentration 8times as high as that of oxidized palmitoyl arachidonyl phosphatidylcholine. Oxidized palmitoyl arachidonyl phosphatidylcholine completely abolishes the inhibitory effect of low density lipoprotein-incorporated sphingomyelin on the enzyme activity at the oxidized palmitoyl arachidonyl phosphatidylcholine/sphingomyelin concentration ratio 1:2

710455

-

3.1.1.4

2 entries

3.1.1.5

0.5 MM, 21% inhibition at pH 5.0, 29% inhibition at pH 7.0, LPL1; 0.5 mM, 35% inhibition of phospholipase B activity, 45% inhibition of lysophospholipase at pH 5.0, 28% inhibition of lysophospholipase at pH 7.0

663943

-

3.1.3.4

72% inhibition at equimolar concentration with pure phosphatidic acid. No effect with equimolar concentrations of phosphatidic acid mixed with phosphatidylcholine

651209

-

3.1.4.11

50% inhibition at 6.5% molar, and 97% at 20% molar

285214

-

3.1.4.11

50% inhibition at low concentration, and 97% at high concentration

285214

-

3.1.4.12

hydrolysis of platelet-activating factor; strong competitive inhibition of platelet-inactivating factor hydrolysis

663974

-

3.1.4.12

strong competitive inhibition of platelet-inactivating factor hydrolysis

663974

-

3.1.4.11

2 entries

3.1.4.12

2 entries

3.1.4.3

competitive

652656

-

3.1.4.50

strong

646486

-

3.1.6.8

inhibition or activation depends on substrate

135676

-

3.5.1.23

-

171993

-

3.5.1.23

ceramide synthesis activity, 5 mol%, 50% inhibition

655998

-

3.5.1.23

2 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (8 results)

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Show Turnover Number (8 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.1.4.12

3.6

-

37°C, pH 7.5

650502

3.1.4.12

210

-

37°C, pH 7.5

651801

3.1.4.12

400

-

-

652701

3.1.4.41

0.004

-

crude enzyme, in HEPES-buffered saline at 37°C

695217

3.1.4.41

0.0065

-

recombinant enzyme SMase I, in HEPES-buffered saline at 37°C

695217

3.1.4.41

0.0175

-

recombinant enzyme SMase II, in HEPES-buffered saline at 37°C

695217

3.1.4.41

0.058

-

37°C, pH 7.4, sphingomyelinase P1

666985

3.1.4.41

0.118

-

37°C, pH 7.4, sphingomyelinase P2

666985

3.1.4.12

3 entries

3.1.4.41

5 entries

K_M Value (44 results)

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Show KM Value (44 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.8.27

0.0356

-

-

668587

3.1.4.12

-999

-

-

135183

3.1.4.12

-999

-

comparison of values from enzymes of normal and mutated tissues

135150

3.1.4.12

-999

-

influence of detergents

135150

3.1.4.12

0.00059

-

-

135188

3.1.4.12

0.0039

-

37°C, pH 7.4

650323

3.1.4.12

0.01871

-

-

665711

3.1.4.12

0.0203

-

in 100 mM Tris-HCl (pH 7.5), at 37°C

705258

3.1.4.12

0.024

-

-

135154

3.1.4.12

0.025

-

-

135159, 135178, 135179

3.1.4.12

0.027

-

37°C, pH 7.4, recombinant nSMase2 in yeast microsomes

652373

3.1.4.12

0.032

-

-

135185

3.1.4.12

0.032

-

37°C, pH 4.8

653119

3.1.4.12

0.038

-

in presence of Mg2+ and Triton X-100

135157

3.1.4.12

0.04

-

37°C, pH 7.4

652090

3.1.4.12

0.055

-

-

135147

3.1.4.12

0.069

-

-

135149

3.1.4.12

0.079

-

-

135155

3.1.4.12

0.095

-

enzyme B

135169

3.1.4.12

0.1

-

-

135160

3.1.4.12

0.1

-

37°C, pH 7.5

649682

3.1.4.12

0.13

-

-

135172

3.1.4.12

0.17

-

in presence of Mg2+ and sodium deoxycholate

135157

3.1.4.12

0.18

-

-

135171

3.1.4.12

0.2

-

-

135187

3.1.4.12

0.3

-

enzyme A

135169

3.1.4.12

0.35

-

37°C, pH 7.5

650502, 651801

3.1.4.12

0.405

-

in presence of Triton X-100

135157

3.1.4.12

0.5

0.9

-

135173

3.1.4.12

0.526

-

-

135156

3.1.4.12

0.565

-

in presence of sodium deoxycholate

135157

3.1.4.12

0.62

-

microsomes

135163

3.1.4.12

1.2

-

lysosomes, at 0.5 mM sphingomyelin

135163

3.1.4.12

1.25

-

37°C, pH 9.0

652706

3.1.4.12

13

-

lysosomes, at 2 mM sphingomyelin

135163

3.1.4.12

60

90

-

135175

3.1.4.3

0.09

-

pH 7.5, 37°C

652656

3.1.4.3

0.8

-

-

133931

3.1.4.12

35 entries

3.1.4.3

2 entries

3.1.4.4

0.56

-

-

135434

3.1.4.41

0.00076

-

at pH 7.4 and 37°C

751183

3.1.4.41

0.02

-

pH 7.5, 37°C

653121

3.1.4.41

0.064

-

37°C, pH 7.4, sphingomyelinase P2

666985

3.1.4.41

0.113

-

37°C, pH 7.4, sphingomyelinase P1

666985

3.1.4.41

6.2

-

-

135478

3.1.4.41

5 entries

References & Links

Literature References (262)

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Show Reference (262 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

133906

7278679

Phospholipase A2 from cobra venom (Naja naja naja)

1981

Deems, R.A.; Dennis, E.A.

Methods Enzymol.

71

703-710

133931

-

Phospholipases

1971

Hanahan, D.J.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

5

71-85

134915

6329308

Dolichyl phosphate phosphatase in rat liver microsomes. Avoidance of the use of detergent in testing the effect of phospholipids on dolichyl phosphate phosphatase

1984

Boscoboinik, D.O.; Morera, S.; Belocopitow, E.

Biochim. Biophys. Acta

794

41-48

135146

2538416

A new Zn2+-stimulated sphingomyelinase in fetal bovine serum

1989

Spence, M.W.; Byers, D.M.; Palmer, F.B.St.C.; Cook, H.W.

J. Biol. Chem.

264

5358-5363

135147

2541739

Purification to homogeneity of human placental acid sphingomyelinase

1989

Zou, L.; Kojima, N.; Kito, M.; Yagi, K.

Biotechnol. Appl. Biochem.

11

217-225

135148

2838331

Sphingomyelinases in human, bovine and porcine seminal plasma

1988

Vanha-Perttula, T.

FEBS Lett.

233

263-267

135149

2825797

Acid sphingomyelinase from human urine: purification and characterization

1987

Quintern, L.E.; Weitz, G.; Nehrkorn, H.; Tager, J.M.; Schram, A.W.; Sandhoff, K.

Biochim. Biophys. Acta

922

323-336

135150

2439128

Presence of immunoreactive material in Niemann-Pick type A placenta using anti-sphingomyelinase rabbit gammaglobulins

1987

Rousson, R.; Bonnet, J.; Louisot, P.; Vanier, M.T.

Biochim. Biophys. Acta

924

502-508

135151

3024666

Immunochemical characterization of two activator proteins stimulating enzymic sphingomyelin degradation in vitro. Absence of one of them in a human Gaucher disease variant

1986

Christomanou, H.; Aignesberger, A.; Linke, R.P.

Biol. Chem. Hoppe-Seyler

367

879-890

135152

4005041

Isolation of two forms of an activator protein for the enzymic sphingomyelin degradation from human Gaucher spleen

1985

Christmanou, H.; Kleinschmidt, T.

Biol. Chem. Hoppe-Seyler

366

245-256

135153

-

Immunological properties of urinary sphingomyelinase

1984

Schram, A.W.; Weitz, G.; Driessen, M.; Brouwer-Kelder, E.M.; Sandhoff, K.; Barranger, J.A.; Tager, J.M.

Biochem. Soc. Trans.

12

1027-1028

135154

6311712

Release of sphingomyelin phosphodiesterase (acid sphingomyelinase) by ammonium chloride from CL 1D mouse L-cells and human fibroblasts. Partial purification and characterization of the exported enzymes

1983

Weitz, G.; Lindl, T.; Hinrichs, U.; Sandhoff, K.

Hoppe-Seyler's Z. Physiol. Chem.

364

863-871

135155

6192193

Partial purification and properties of acid sphingomyelinase from rat liver

1983

Watanabe, K.; Sakuragawa, N.; Arima, M.; Satoyoshi, E.

J. Lipid Res.

24

596-603

135156

6292172

Acid sphingomyelinase of human placenta: purification, properties, and 125iodine labeling

1982

Sakuragawa, N.

J. Biochem.

92

637-646

135157

6284239

Molecular properties and kinetic studies on sphingomyelinase of Bacillus cereus

1982

Tomita, M.; Taguchi, R.; Ikezawa, H.

Biochim. Biophys. Acta

704

90-99

135158

6284123

Hydrolysis of monomolecular layers of synthetic sphingomyelins by sphingomyelinase of Staphylococcus aureus

1982

Yedgar, S.; Cohen, R.; Gatt, S.; Barenholz, Y.

Biochem. J.

201

597-603

135159

6274305

Purification of sphingomyelinase to apparent homogeneity by using hydrophobic chromatography

1981

Jones, C.S.; Shankaran, P.; Callahan, J.W.

Biochem. J.

195

373-382

135160

6260779

Acid sphingomyelinase of human brain. Improved purification procedures and characterization

1981

Yamanaka, T.; Hanada, E.; Suzuki, K.

J. Biol. Chem.

256

3884-3889

135161

6272705

Studies on the hydrophobic properties of sphingomyelinase

1981

Callahan, J.W.; Gerrie, J.; Jones, C.S.; Shankaran, P.

Biochem. J.

193

275-283

135162

6257302

A lysosomal storage disorder in mice characterized by a dual deficiency of sphingomyelinase and glucocerebrosidase

1980

Pentchev, P.G.; Gal, A.E.; Booth, A.D.; Omodeo-Sale, F.; Fouks, J.; Neumeyer, B.A.; Quirk, J.M.; Dawson, G.; Brady, R.O.

Biochim. Biophys. Acta

619

669-679

135163

37279

The subcellular localization of neutral sphingomyelinase in rat liver

1979

Hostetler, K.Y.; Yazaki, P.J.

J. Lipid Res.

20

456-463

135165

26680

A novel magnesium-independent neutral sphingomyelinase associated with rat central nervous system myelin

1978

Yamaguchi, S.; Suzuki, K.

J. Biol. Chem.

253

4090-4092

135166

23854

Studies on sphingomyelinase of Bacillus cereus. I. Purification and properties

1978

Ikezawa, H.; Mori, M.; Ohyabu, T.; Taguchi, R.

Biochim. Biophys. Acta

528

247-256

135167

-

The purification of beta-lysin (sphingomyelinase C) from Staphylococcus aureus

1977

Low, D.K.R.; Freer, J.H.

FEMS Microbiol. Lett.

2

139-143

135168

19083

The isolation and characterization of sphingomyelinase from human placental tissue

1977

Pentchev, P.G.; Brady, R.O.; Gal, A.E.; Hibbert, S.R.

Biochim. Biophys. Acta

488

312-321

135169

16918

Purification and characterization of sphingomyelinase from human brain

1977

Yamaguchi, S.; Suzuki, K.

J. Biol. Chem.

252

3805-3813

135170

174564

Magnesium-dependent sphingomyelinase

1976

Gatt, S.

Biochem. Biophys. Res. Commun.

68

235-241

135171

5933867

The metabolism of sphingomyelin. I. Purification and properties of a sphingomyelin-cleaving enzyme from rat liver tissue

1966

Kanfer, J.N.; Young, O.M.; Shapiro, D.; Brady, R.O.

J. Biol. Chem.

241

1081-1084

135172

5916388

Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain

1966

Barnholz, Y.; Roitman, A.; Gatt, S.

J. Biol. Chem.

241

3731-3737

135173

5911524

Enzymic hydrolysis of sphingomyelin by rat liver

1966

Heller, M.; Shapiro, B.

Biochem. J.

98

763-769

135175

8418889

Characterization of the neutral pH-optimum sphingomyelinase from rat brain: inhibition by copper II and ganglioside GM3

1993

Lister, M.D.; Crawford-Redick, C.L.; Loomis, C.R.

Biochim. Biophys. Acta

1165

314-320

135178

8985151

Purification of acid sphingomyelinase from human placenta: Characterization and N-terminal sequence

1996

Lansmann, S.; Ferlinz, K.; Hurwitz, R.; Bartelsen, O.; Glombitza, G.; Sandhoff, K.

FEBS Lett.

399

227-231

135179

9328299

Purification of a newly identified alkaline sphingomyelinase in human bile and effects of bile salts and phosphatidylcholine on enzyme activity

1997

Duan, R.D.; Nilsson, A.

Hepatology

26

823-830

135180

9240970

Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin

1997

Mansat, V.; Bettaieb, A.; Levade, T.; Laurent, G.; Jaffrezou, J.P.

FASEB J.

11

695-702

135181

9126282

Characterization of a sphingomyelinase activity in Saccharomyces cerevisiae

1997

Ella, K.M.; Qi, C.; Dolan, J.W.; Thompson, R.P.; Meier, K.E.

Arch. Biochem. Biophys.

340

101-110

135182

9879667

Identification, partial purification, and localization of a neutral sphingomyelinase in rabbit skeletal muscle: neutral sphingomyelinase in skeletal muscle

1998

Gosh, N.; Sabbadini, R.; Chatterjee, S.

Mol. Cell. Biochem.

189

161-168

135183

9852115

Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain

1998

Liu, B.; Hassler, D.F.; Smith, G.K.; Weaver, K.; Hannun, Y.A.

J. Biol. Chem.

273

34472-34479

135184

10601312

Molecular cloning, characterization, and expression of a novel human neutral sphingomyelinase

1999

Chatterjee, S.; Han, H.; Rollins, S.; Cleveland, T.

J. Biol. Chem.

274

37407-37412

135185

9764481

Expression of recombinant human acid sphingomyelinase in insect Sf21 cells: purification, processing and enzymatic characterization

1998

Bartelsen, O.; Lansmann, S.; Nettersheim, M.; Le mM, T.; Ferlinz, K.; Sandhoff, K.

J. Biotechnol.

63

29-40

135186

10407147

Characterization of human acid sphingomyelinase purified from the media of overexpressing chinese hamster ovary cells

1999

He, X.; Miranda, S.R.P.; Xiong, X.; Dagan, A.; Gatt, S.; Schuchman, E.H.

Biochim. Biophys. Acta

1432

251-264

135187

11001562

Characterization of acidic and neutral sphingomyelinase activities in crude extracts of HL-60 cells

1999

Samet, D.; Barenholz, Y.

Chem. Phys. Lipids

102

65-77

135188

10625655

A neutral magnesium-dependent sphingomyelinase isoform associated with intracellular membranes and reversibly inhibited by reactive oxygen species

2000

Fensome, A.C.; Rodrigues-Lima, F.; Josephs, M.; Paterson, H.F.; Katan, M.

J. Biol. Chem.

275

1128-1136

135286

8722307

Characterization of a phospholipase C produced by Pseudomaonas fluorescens

1996

Ivanov, A.; Titibali, R.W.; Kostadinova, S.

New Microbiol.

19

113-121

135292

1904842

Purification and characterization of an extracellular 29-kilodalton phospholipase C from Listeria monocytogenes

1991

Geoffroy, C.; Raveveau, J.; Beretti, J.L.; Lecroisey, A.; Vazquez-Boland, J.A.; Alouf, J.E.; Berche, P.

Infect. Immun.

59

2382-2388

135296

6329100

Phospholipase C from Clostridium perfringens: Preparation and characterization of homogenous enzyme

1984

Krug, E.; Kent, C.

Arch. Biochem. Biophys.

231

400-410

135297

6811552

Phospholipase C (heat-labile hemolysin) of Pseudomonas aeruginosa: Purification and preliminary characterization

1982

Berka, R.M.; Vasil, M.L.

J. Bacteriol.

152

239-245

135298

6268935

Phospholipase C from Clostridium perfringens

1981

Takahashi, T.; Sugahara, T.; Ohsaka, A.

Methods Enzymol.

71

710-725

135299

-

Phospholipase C from Bacillus cereus

1981

Little, C.

Methods Enzymol.

71

725-730

135307

5411

Studies on phospholipases from Streptomyces. Purification and properties of Streptomyces hachijoensis phospholipase C

1975

Okawa, Y.; Yamaguchi, T.

J. Biochem.

78

537-545

135308

4216738

Phospholipase C (phosphatidylcholine cholinephosphohydrolase, EC 3.1.4.3) from Bacillus cereus

1974

Zwaal, R.F.A.; Roelofsen, B.

Methods Enzymol.

32

154-161

135434

762053

Purification of Streptomyces chromofuscus phospholipase D by hydrophobic affinity chromatography on palmitoyl cellulose

1979

Imamura, S.; Horiuti, Y.

J. Biochem.

85

79-95

135435

6440

Studies on phospholipases from Streptomyces

1974

Okawa, Y.; Yamaguchi, T.

J. Biochem.

78

363-372

135445

7551587

Purification and characterization of phospholipase D (PLD) from rice (Oryza sativa L.) and cloning of cDNA for PLD from rice and maize (Zea mays L.)

1995

Ueki, J.; Morioka, S.; Komari, T.; Kumashiro, T.

Plant Cell Physiol.

36

903-914

135456

-

Purification and properties of phospholipase D from Streptomyces antibioticus

1993

Shimbo, K.; Iwasaki,Y.; Yamane, T.; Ina,K.

Biosci. Biotechnol. Biochem.

57

1946-1948

135478

5543581

Identification and characterization of a new enzyme of the group "phospholipase D" isolated from Corynebacterium ovis

1971

Soucek, A.; Michalec, C.; Souckova, A.

Biochim. Biophys. Acta

227

116-128

135479

622164

Action of Corynebacterium ovis exotoxin on endothelial cells of blood vessels

1978

Carne, H.R.; Onon, E.O.

Nature

271

246-248

135480

208467

Red blood cell lysis induced by the venom of brown recluse spider

1978

Forrester, L.J.; Barrett, J.T.; Campbell, B.J.

Arch. Biochem. Biophys.

187

355-365

135481

426767

Purification and partial characterization of the exotoxin of Corynebacterium ovis

1979

Onon, E.O.

Biochem. J.

177

181-186

135482

6274420

Platelet aggregation and sphingomyelinase D activity of a purified toxin from the venom of Loxosceles rescula

1981

Kurpiewski, G.; Forrester, L.J.; Barrett, J.T.; Campbell, B.J.

Biochim. Biophys. Acta

678

467-476

135483

7073283

Enzymatic oxidation of membrane cholesterol in relation to lysis of sheep erythrocytes by corynebacterial enzymes

1982

Linder, R; Bernheimer, A.W.

Arch. Biochem. Biophys.

213

395-404

135484

2890587

Phospholipase D activity of Vibrioi damsela cytolysin and its interaction with sheep erythrocytes

1987

Kreger, A.S.; Bernheimer, A.W.; Etkin, L.A.; Daniel, L.W.

Infect. Immun.

55

3209-3212

135485

8397477

Sphingomyelinase D: A pathogenic agent produced by bacteria and arthropods

1993

Truett III, A.P.; King, L.E.

Adv. Lipid Res.

26

275-291

135486

2403529

Cloning and expression of the phospholipase D gene from Corynebacterium pseudotuberculosis in Escherichia coli

1990

Songer, J.G.; Libby, S.J.; Iandolo, J.J.; Cuevas, W.A.

Infect. Immun.

58

131-136

135487

1965062

Serum amyloid P component: its role in platelet activation stimulated by sphingomyelinase D purified from the venom of the brown recluse spider (Loxosceles reclusa)

1990

Gates, C.A.; Rees, R.S.

Toxicon

28

1303-1315

135676

235289

Comparison of the cerebroside sulphatase and the arylsulphatase activity of human sulphatase A in the absence of activators

1975

Stinshoff, K.; Jatzkewitz, H.

Biochim. Biophys. Acta

377

126-138

171993

7759519

Purifiction and biochemical characterization of membrane-bound epidermal ceramides from guinea pig skin

1995

Yada, Y.; Higuchi, K.; Imokawa, G.

J. Biol. Chem.

270

12677-12684

285214

2996496

The inhibition of diacylglycerol-stimulated intracellular phospholipases by phospholipids with a phosphocholine-containing polar group. A possible physiological role for sphingomyelin

1985

Dawson, R.M.C.; Hemington, N.; Irvine, R.F.

Biochem. J.

230

61-68

288938

7592649

A novel enzyme that cleaves the N-acyl linkage of ceramides in various glycospingolipids as well as sphingomyelin to produce their lyso forms

1995

Ito, M.; Kurita, T.; Kita, K.

J. Biol. Chem.

41

24370-24374

438227

-

The enzymatic conversion of all-trans beta-carotene into retinal

1967

Goodman, D.S.; Huang, H.S.; Kanai, M.; Shiratori, T.

J. Biol. Chem.

242

3543-3554

486606

11283027

Identification, purification, and characterization of monoacylglycerol acyltransferase from developing peanut cotyledons

2001

Tumaney, A.W.; Shekar, S.; Rajasekharan, R.

J. Biol. Chem.

276

10847-10852

486608

7669782

Sphingosine inhibits rat hepatic monoacylglycerol acyltransferase in Triton X-100 mixed micelles and isolated hepatocytes

1995

Bhat, B.G.; Wang, P.; Coleman, R.A.

Biochemistry

34

11237-11244

486677

-

Acyl coenzyme A:cholesterol O-acyltransferase

1983

Chang, T.Y.; Doolittle, G.M.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

16

523-539

487010

11111093

Lecithin cholesterol acyltransferase

2000

Jonas, A.

Biochim. Biophys. Acta

1529

245-256

489438

3620503

Purification and properties of a mannosyltransferase solubilized from mitochondrial outer membranes

1987

Gasnier, F.; Morelis, R.; Louisot, P.; Gateau, O.

Biochim. Biophys. Acta

925

297-304

489482

19076

Solubilization and partial characterization of UDP-N-acetylgalactosamine: globoside alpha-N-acetylgalactosaminyltransferase from dog spleen microsomes

1977

Ishibashi, T.; Ohkubo, I.; Makita, A.

Biochim. Biophys. Acta

484

24-34

640370

6296111

Diacylglycerol kinase from pig brain. Purification and phospholipid dependencies

1983

Kanoh, H.; Kondoh, H.; Ono, T.

J. Biol. Chem.

258

1767-1774

642127

2550036

The purification and properties of monoacylglycerol kinase from bovine brain

1989

Shim, Y.H.; Lin, C.H.; Strickland, K.P.

Biochem. Cell Biol.

67

233-241

642915

10569945

CTP:phosphocholine cytidylyltransferase activation by oxidized phosphatidylcholines correlates with a decrease in lipid prder: A 2H NMR analysis

1999

Drobnies, A.E.; Van der Ende, B.; Thewalt, J.L.; Cornell, R.B.

Biochemistry

38

15606-15614

643311

6288204

Biosynthesis of CDP-diacylglycerol in hog mesenteric lymph node lymphocytes

1982

Sribney, M.; Hegadorn, C.A.

J. Biochem.

60

668-674

645807

8424947

Inhibition of tyrosylprotein sulfotransferase by sphingosine and its reversal by acidic phospholipids

1993

Kasinathan, C.; Sundaram, P.; Slomiany, B.L.; Slomiany, A.

Biochemistry

32

1194-1198

646486

10937880

Glycosylphosphatidylinositol-specific phospholipase D of human serum--activity modulation by naturally occurring amphiphiles

2000

Rhode, H.; Schulze, M.; Cumme, G.A.; Gohlert, A.; Blume, E.; Bublitz, R.; Schilling, K.; Horn, A.

Biol. Chem.

381

471-485

646527

8565784

Comparison of purified human and rabbit serum paraoxonases

1995

Kuo, C.L.; La Du, B.N.

Drug Metab. Dispos.

23

935-944

649563

11162568

Effect of overexpression of a neutral sphingomyelinase on CD95-induced ceramide production and apoptosis

2001

Tepper, A.D.; Ruurs, P.; Borst, J.; van Blitterswijk, W.J.

Biochem. Biophys. Res. Commun.

280

634-639

649682

-

Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum

2000

Hanada, K.; Mitamura, T.; Fukasawa, M.; Magistrado, P.A.; Horii, T.; Nishijima, M.

Biochem. J.

346

671-677

649984

10769141

Purification and characterization of neutral sphingomyelinase from Helicobacter pylori

2000

Chan, E.C.; Chang, C.C.; Li, Y.S.; Chang, C.A.; Chiou, C.C.; Wu, T.Z.

Biochemistry

39

4838-4845

650323

10832103

Cloning and expression of rat neutral sphingomyelinase: enzymological characterization and identification of essential histidine residues

2000

Mizutani, Y.; Tamiya-Koizumi, K.; Irie, F.; Hirabayashi, Y.; Miwa, M.; Yoshida, S.

Biochim. Biophys. Acta

1485

236-246

650366

12069857

Processive interfacial catalytic turnover by Bacillus cereus sphingomyelinase on sphingomyelin vesicles

2002

Yu, B.Z.; Zakim, D.; Jain, M.K.

Biochim. Biophys. Acta

1583

122-132

650502

12843611

His151 and His296 are the acid-base catalytic residues of Bacillus cereus sphingomyelinase in sphingomyelin hydrolysis

2003

Obama, T.; Fujii, S.; Ikezawa, H.; Ikeda, K.; Imagawa, M.; Tsukamoto, K.

Biol. Pharm. Bull.

26

920-926

650584

12496108

Bidirectional control of sphingomyelinase activity and surface topography in lipid monolayers

2002

Fanani, M.L.; Hartel, S.; Oliveira, R.G.; Maggio, B.

Biophys. J.

83

3416-3424

650896

12781970

The phylogenetic distribution of sphingomyelinase D activity in venoms of Haplogyne spiders

2003

Binford, G.J.; Wells, M.A.

Comp. Biochem. Physiol. B

135

25-33

651148

12631268

Human acid sphingomyelinase: Assignment of the disulfide bond pattern

2003

Lansmann, S.; Schuette, C.G.; Bartelsen, O.; Hoernschemeyer, J.; Linke, T.; Weisgerber, J.; Sandhoff, K.

Eur. J. Biochem.

270

1076-1088

651209

10914334

Characterization of the pulmonary N-ethylmaleimide-insensitive phosphatidate phosphohydrolase

2000

Nanjundan, M.; Possmayer, F.

Exp. Lung Res.

26

361-381

651315

12401200

Sphingomyelinases: enzymology and membrane activity

2002

Goni, F.M.; Alonso, A.

FEBS Lett.

531

38-46

651338

14741383

Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases

2004

Miura, Y.; Gotoh, E.; Nara, F.; Nishijima, M.; Hanada, K.

FEBS Lett.

557

288-292

651708

11751833

Molecular cloning and expression of Mn2+-dependent sphingomyelinase/hemolysin of an aquatic bacterium, Pseudomonas sp. strain TK4

2002

Sueyoshi, N.; Kita, K.; Okino, N.; Sakaguchi, K.; Nakamura, T.; Ito, M.

J. Bacteriol.

184

540-546

651801

12761162

Glu-53 of Bacillus cereus sphingomyelinase acts as an indispensable ligand of Mg2+ essential for catalytic activity

2003

Obama, T.; Kan, Y.; Ikezawa, H.; Imagawa, M.; Tsukamoto, K.

J. Biochem.

133

279-286

652079

10681556

Characterization and subcellular localization of murine and human magnesium-dependent neutral sphingomyelinase

2000

Tomiuk, S.; Zumbansen, M.; Stoffel, W.

J. Biol. Chem.

275

5710-5717

652090

10713073

Purification and characterization of a magnesium-dependent neutral sphingomyelinase from bovine brain

2000

Bernardo, K.; Krut, O.; Wiegmann, K.; Kreder, D.; Micheli, M.; Schafer, R.; Sickman, A.; Schmidt, W.E.; Schroder, J.M.; Meyer, H.E.; Sandhoff, K.; Kronke, M.

J. Biol. Chem.

275

7641-7647

652373

12566438

Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism

2003

Marchesini, N.; Luberto, C.; Hannun, Y.A.

J. Biol. Chem.

278

13775-13783

652444

12801930

Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine

2003

Qiu, H.; Edmunds, T.; Baker-Malcolm, J.; Karey, K.P.; Estes, S.; Schwarz, C.; Hughes, H.; Van Patten, S.M.

J. Biol. Chem.

278

32744-32752

652461

12885774

Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family

2003

Duan, R.D.; Bergman, T.; Xu, N.; Wu, J.; Cheng, Y.; Duan, J.; Nelander, S.; Palmberg, C.; Nilsson, A.

J. Biol. Chem.

278

38528-38536

652516

14732720

Spider and bacterial sphingomyelinases D target cellular lysophosphatidic acid receptors by hydrolyzing lysophosphatidylcholine

2004

Van Meeteren, L.A.; Frederiks, F.; Giepmans, B.N.G.; Pedrosa, M.F.F.; Billington, S.J.; Jost, B.H.; Tambourgi, D.V.; Moolenaar, W.H.

J. Biol. Chem.

279

10833-10836

652543

15051724

Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells

2004

Marchesini, N.; Osta, W.; Bielawski, J.; Luberto, C.; Obeid, L.M.; Hannun, Y.A.

J. Biol. Chem.

279

25101-25111

652601

11707524

Nuclear localization of neutral sphingomyelinase 1: biochemical and immunocytochemical analyses

2001

Mizutani, Y.; Tamiya-Koizumi, K.; Nakamura, N.; Kobayashi, M.; Hirabayashi, Y.; Yoshida, S.

J. Cell Sci.

114

3727-3736

652656

11781362

Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy

2002

Hanada, K.; Palacpac, N.M.Q.; Magistrado, P.A.; Kurokawa, K.; Rai, G.; Sakata, D.; Hara, T.; Horii, T.; Nishijima, M.; Mitamura, T.

J. Exp. Med.

195

23-34

652701

11060353

Kinetic steps for the hydrolysis of sphingomyelin by Bacillus cereus sphingomyelinase in lipid monolayers

2000

Fanani, M.L.; Maggio, B.

J. Lipid Res.

41

1832-1840

652706

11861674

Purification, characterization, and expression of rat intestinal alkaline sphingomyelinase

2002

Cheng, Y.; Nilsson, A.; Tomquist, E.; Duan, R.D.

J. Lipid Res.

43

316-324

652708

12777467

Sphingomyelinase D, a novel probe for cellular sphingomyelin: effects on cholesterol homeostasis in human skin fibroblasts

2003

Subbaiah, P.V.; Billington, S.J.; Jost, B.H.; Songer, J.G.; Lange, Y.

J. Lipid Res.

44

1574-1580

652972

10936181

Identification of multiple forms of membrane-associated neutral sphingomyelinase in bovine brain

2000

Jung, S.Y.; Suh, J.H.; Park, H.J.; Jung, K.M.; Kim, M.Y.; Na, D.S.; Kim, D.K.

J. Neurochem.

75

1004-1014

652974

14720208

The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase

2004

Won, J.S.; Im, Y.B.; Khan, M.; Singh, A.K.; Singh, I.

J. Neurochem.

88

583-593

653103

12056588

In vitro effects of fat, FA, and cholesterol on sphingomyelin hydrolysis induced by rat intestinal alkaline sphingomyelinase

2002

Liu, J.J.; Nilsson, A.; Duan, R.D.

Lipids

37

469-474

653119

10563319

Purification and characterization of recombinant human acid sphingomyelinase expressed in insect Sf21 cells

2000

Lansmann, S.; Bartelsen, O.; Sandhoff, K.

Methods Enzymol.

311

149-156

653120

10563320

Purification of rat brain membrane neutral sphingomyelinase

2000

Liu, B.; Hannun, Y.A.

Methods Enzymol.

311

156-164

653121

10563323

A high throughput sphingomyelinase assay

2000

Hassler, D.F.; Laethem, R.M.; Smith, G.K.

Methods Enzymol.

311

176-184

653652

10823942

Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase

2000

Hofmann, K.; Tomiuk, S.; Wolff, G.; Stoffel, W.

Proc. Natl. Acad. Sci. USA

97

5895-5900

655998

11278489

Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase

2001

El Bawab, S.; Birbes, H.; Roddy, P.; Szulc, Z.M.; Bielawska, A.; Hannun, Y.A.

J. Biol. Chem.

276

16758-16766

660431

15039073

Purification and characterization of two recombinant human glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate in Escherichia coli

2004

Kakuda, S.; Oka, S.; Kawasaki, T.

Protein Expr. Purif.

35

111-119

661980

2120196

Molecular comparison of a nonhemolytic and a hemolytic phospholipase C from Pseudomonas aeruginosa

1990

Ostroff, R.M.; Vasil, A.I.; Vasil, M.L.

J. Bacteriol.

172

5915-5923

662891

12410824

A novel class of microbial phosphocholine-specific phospholipases C

2002

Stonehouse, M.J.; Cota-Gomez, A.; Parker, S.K.; Martin, W.E.; Hankin, J.A.; Murphy, R.C.; Chen, W.; Lim, K.B.; Hackett, M.; Vasil, A.I.; Vasil, M.L.

Mol. Microbiol.

46

661-676

663894

16480957

Structural insights into the catalytic mechanism of sphingomyelinases D and evolutionary relationship to glycerophosphodiester phosphodiesterases

2006

Murakami, M.T.; Fernandes-Pedrosa, M.F.; de Andrade, S.A.; Gabdoulkhakov, A.; Betzel, C.; Tambourgi, D.V.; Arni, R.K.

Biochem. Biophys. Res. Commun.

342

323-329

663943

15320865

Cryptococcal phospholipases: a novel lysophospholipase discovered in the pathogenic fungus Cryptococcus gattii

2004

Wright, L.C.; Payne, J.; Santangelo, R.T.; Simpanya, M.F.; Chen, S.C.; Widmer, F.; Sorrell, T.C.

Biochem. J.

384

377-384

663974

16255717

Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity

2006

Wu, J.; Nilsson, A.; Jonsson, B.A.; Stenstad, H.; Agace, W.; Cheng, Y.; Duan, R.D.

Biochem. J.

394

299-308

664187

15878423

Premicellar complexes of sphingomyelinase mediate enzyme exchange for the stationary phase turnover

2005

Yu, B.Z.; Polenova, T.; Jain, M.K.; Berg, O.G.

Biochim. Biophys. Acta

1712

137-151

664216

16631405

Alkaline sphingomyelinase: An old enzyme with novel implications

2006

Duan, R.D.

Biochim. Biophys. Acta

1761

281-291

664217

16278077

Role of tyrosine-57 and -65 in membrane-damaging and sphingomyelinase activities of Clostridium perfringens alpha-toxin

2006

Nagahama, M.; Otsuka, A.; Sakurai, J.

Biochim. Biophys. Acta

1762

110-114

664262

15653433

Functional characterization of the postulated intramolecular sphingolipid activator protein domain of human acid sphingomyelinase

2004

Koelzer, M.; Ferlinz, K.; Bartelsen, O.; Hoops, S.L.; Lang, F.; Sandhoff, K.

Biol. Chem.

385

1193-1195

664590

15172829

Cholesterol modulation of sphingomyelinase activity at physiological temperatures

2004

Contreras, F.X.; Sot, J.; Ruiz-Arguello, M.B.; Alonso, A.; Goni, F.M.

Chem. Phys. Lipids

130

127-134

664837

14728687

Purification and functional characterization of insecticidal sphingomyelinase C produced by Bacillus cereus

2004

Nishiwaki, H.; Ito, K.; Otsuki, K.; Yamamoto, H.; Komai, K.; Matsuda, K.

Eur. J. Biochem.

271

601-606

664859

16026583

Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging

2005

Jensen, J.M.; Forl, M.; Winoto-Morbach, S.; Seite, S.; Schunck, M.; Proksch, E.; Schutze, S.

Exp. Dermatol.

14

609-618

665610

15654080

Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases D

2005

Murakami, M.T.; Fernandes-Pedrosa, M.F.; Tambourgi, D.V.; Arni, R.K.

J. Biol. Chem.

280

13658-13664

665711

16517606

Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein

2006

Krut, O.; Wiegmann, K.; Kashkar, H.; Yazdanpanah, B.; Kronke, M.

J. Biol. Chem.

281

13784-13793

665716

16595670

Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from bacillus cereus

2006

Ago, H.; Oda, M.; Takahashi, M.; Tsuge, H.; Ochi, S.; Katunuma, N.; Miyano, M.; Sakurai, J.

J. Biol. Chem.

281

16157-16167

666380

16540172

Sphingomyelinases D induce direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis

2007

Tambourgi, D.V.; Pedrosa, M.F.; de Andrade, R.M.; Billington, S.J.; Griffiths, M.; van den Berg, C.W.

Mol. Immunol.

44

576-582

666743

15764706

Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development

2005

Stoffel, W.; Jenke, B.; Block, B.; Zumbansen, M.; Koebke, J.

Proc. Natl. Acad. Sci. USA

102

4554-4559

666985

16458340

Kinetic and mechanistic characterization of the sphingomyelinases D from Loxosceles intermedia spider venom

2006

de Andrade, S.A.; Murakami, M.T.; Cavalcante, D.P.; Arni, R.K.; Tambourgi, D.V.

Toxicon

47

380-386

668587

12914942

Reverse sphingomyelin-synthase in rat liver chromatin

2003

Albi, E.; Lazzarini, R.; Magni, M.V.

FEBS Lett.

549

152-156

672155

16605271

Regulation of the activity and fatty acid specificity of lecithin-cholesterol acyltransferase by sphingomyelin and its metabolites, ceramide and ceramide phosphate

2006

Subbaiah, P.V.; Horvath, P.; Achar, S.B.

Biochemistry

45

5029-5038

677602

17508908

Acid sphingomyelinase and its redox amplification in formation of lipid raft redox signaling platforms in endothelial cells

2007

Zhang, A.Y.; Yi, F.; Jin, S.; Xia, M.; Chen, Q.Z.; Gulbins, E.; Li, P.L.

Antioxid. Redox Signal.

9

817-828

677818

17169322

Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism

2007

Martin, S.F.; Sawai, H.; Villalba, J.M.; Hannun, Y.A.

Arch. Biochem. Biophys.

459

295-300

677875

16269668

Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors

2006

De Palma, C.; Meacci, E.; Perrotta, C.; Bruni, P.; Clementi, E.

Arterioscler. Thromb. Vasc. Biol.

26

99-105

677878

16696862

Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: An in vitro study

2006

Gilbert, S.J.; Blain, E.J.; Jones, P.; Duance, V.C.; Mason, D.J.

Arthritis Res. Ther.

8

R89

678083

18001268

Phosphatidylcholine/sphingomyelin metabolism crosstalk inside the nucleus

2008

Albi, E.; Lazzarini, R.; Viola Magni, M.

Biochem. J.

410

381-389

678142

16981685

The extended family of neutral sphingomyelinases

2006

Clarke, C.J.; Snook, C.F.; Tani, M.; Matmati, N.; Marchesini, N.; Hannun, Y.A.

Biochemistry

45

11247-11256

678250

18052040

Carboxyl-terminal disulfide bond of acid sphingomyelinase is critical for its secretion and enzymatic function

2007

Lee, C.Y.; Tamura, T.; Rabah, N.; Lee, D.Y.; Ruel, I.; Hafiane, A.; Iatan, I.; Nyholt, D.; Laporte, F.; Lazure, C.; Wada, I.; Krimbou, L.; Genest, J.

Biochemistry

46

14969-14978

678375

16938269

Neutral sphingomyelinases and nSMase2: bridging the gaps

2006

Clarke, C.J.; Hannun, Y.A.

Biochim. Biophys. Acta

1758

1893-1901

678414

17560896

Leakage-free membrane fusion induced by the hydrolytic activity of PlcHR(2), a novel phospholipase C/sphingomyelinase from Pseudomonas aeruginosa

2007

Montes, L.R.; Ibarguren, M.; Goni, F.M.; Stonehouse, M.; Vasil, M.L.; Alonso, A.

Biochim. Biophys. Acta

1768

2365-2372

678469

18082635

Identification, cloning and functional characterization of a novel dermonecrotic toxin (phospholipase D) from brown spider (Loxosceles intermedia) venom

2008

Appel, M.H.; da Silveira, R.B.; Chaim, O.M.; Paludo, K.S.; Silva, D.T.; Chaves, D.M.; da Silva, P.H.; Mangili, O.C.; Senff-Ribeiro, A.; Gremski, W.; Nader, H.B.; Veiga, S.S.

Biochim. Biophys. Acta

1780

167-178

678819

17284826

Expression of a functional sphingomyelinase of Pseudomonas sp. TK4 in mammalian cells

2007

Horibata, Y.; Sueyoshi, N.; Ito, M.

Biosci. Biotechnol. Biochem.

71

603-606

678939

18088425

Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol

2007

Dastani, Z.; Ruel, I.L.; Engert, J.C.; Genest, J.; Marcil, M.

BMC Med. genet.

8

79

678957

17923876

Identification of aberrant forms of alkaline sphingomyelinase (NPP7) associated with human liver tumorigenesis

2007

Cheng, Y.; Wu, J.; Hertervig, E.; Lindgren, S.; Duan, D.; Nilsson, A.; Duan, R.D.

Br. J. Cancer

97

1441-1448

679082

17652769

The initial surface composition and topography modulate sphingomyelinase-driven sphingomyelin to ceramide conversion in lipid monolayers

2007

De Tullio, L.; Maggio, B.; Hartel, S.; Jara, J.; Fanani, M.L.

Cell Biochem. Biophys.

47

169-177

679144

16549336

Acid sphingomyelinase mediated release of ceramide is essential to trigger the mitochondrial pathway of apoptosis by galectin-1

2006

Ion, G.; Fajka-Boja, R.; Kovacs, F.; Szebeni, G.; Gombos, I.; Czibula, A.; Matko, J.; Monostori, E.

Cell. Signal.

18

1887-1896

679604

17353227

Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow

2007

Doehner, W.; Bunck, A.C.; Rauchhaus, M.; von Haehling, S.; Brunkhorst, F.M.; Cicoira, M.; Tschope, C.; Ponikowski, P.; Claus, R.A.; Anker, S.D.

Eur. Heart J.

28

821-828

679649

-

Sphingomyelinase and ceramidase in the intestinal tract

2007

Duan, R.

Eur. J. Lipid Sci. Technol.

109

987-993

679682

17498692

Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells

2007

Castillo, S.S.; Levy, M.; Thaikoottathil, J.V.; Goldkorn, T.

Exp. Cell Res.

313

2680-2686

679685

17239851

Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis

2007

Castillo, S.S.; Levy, M.; Wang, C.; Thaikoottathil, J.V.; Khan, E.; Goldkorn, T.

Exp. Cell Res.

313

816-823

680063

16941686

Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury

2006

Llacuna, L.; Mari, M.; Garcia-Ruiz, C.; Fernandez-Checa, J.C.; Morales, A.

Hepatology

44

561-572

680065

17668873

Aging in rat causes hepatic hyperresponsiveness to interleukin-1beta which is mediated by neutral sphingomyelinase-2

2007

Rutkute, K.; Karakashian, A.A.; Giltiay, N.V.; Dobierzewska, A.; Nikolova-Karakashian, M.N.

Hepatology

46

1166-1176

680143

17698574

Constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar Typhimurium

2007

McCollister, B.D.; Myers, J.T.; Jones-Carson, J.; Voelker, D.R.; Vazquez-Torres, A.

Infect. Immun.

75

5346-5352

680745

17272284

Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization

2007

Tani, M.; Hannun, Y.A.

J. Biol. Chem.

282

10047-10056

680754

17303575

Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation

2007

Zeidan, Y.H.; Hannun, Y.A.

J. Biol. Chem.

282

11549-11561

680767

17085432

Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2

2007

Clarke, C.J.; Truong, T.G.; Hannun, Y.A.

J. Biol. Chem.

282

1384-1396

681249

17344933

Upregulation of Cytokine Expression in Fibroblasts Exposed to Loxosceles Sphingomyelinase D: What is the Trigger?

2007

van Meeteren, L.A.; Stortelers, C.; Moolenaar, W.H.

J. Invest. Dermatol.

127

1266-1267

681259

16775254

A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products

2006

Walton, K.A.; Gugiu, B.G.; Thomas, M.; Basseri, R.J.; Eliav, D.R.; Salomon, R.G.; Berliner, J.A.

J. Lipid Res.

47

1967-1974

681266

17556754

Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes

2007

Coll, O.; Morales, A.; Fernandez-Checa, J.C.; Garcia-Ruiz, C.

J. Lipid Res.

48

1924-1935

681268

17693623

Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation

2007

Rutkute, K.; Asmis, R.H.; Nikolova-Karakashian, M.N.

J. Lipid Res.

48

2443-2452

681322

18027916

Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model

2008

Kornhuber, J.; Tripal, P.; Reichel, M.; Terfloth, L.; Bleich, S.; Wiltfang, J.; Gulbins, E.

J. Med. Chem.

51

219-237

681689

17344303

Sphingomyelinase restricts the lateral diffusion of CD4 and inhibits human immunodeficiency virus fusion

2007

Finnegan, C.M.; Rawat, S.S.; Cho, E.H.; Guiffre, D.L.; Lockett, S.; Merrill, A.H.; Blumenthal, R.

J. Virol.

81

5294-5304

681794

17526847

Characterization of two distinct phospholipase C enzymes from Burkholderia pseudomallei

2007

Korbsrisate, S.; Tomaras, A.P.; Damnin, S.; Ckumdee, J.; Srinon, V.; Lengwehasatit, I.; Vasil, M.L.; Suparak, S.

Microbiology

153

1907-1915

682246

17211142

Human meconium contains significant amounts of alkaline sphingomyelinase, neutral ceramidase, and sphingolipid metabolites

2006

Duan, R.; Cheng, Y.; Joensson, B.A.; Ohlsson, L.; Herbst, A.; Hellstroem-Westas, L.; Nilsson, A.

Pediatr. Res.

61

61-66

682477

17583825

Curcumin decreases acid sphingomyelinase activity in colon cancer Caco-2 cells

2007

Cheng, Y.; Kozubek, A.; Ohlsson, L.; Sternby, B.; Duan, R.D.

Planta Med.

73

725-730

682983

17876892

Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function

2007

Bock, J.; Liebisch, G.; Schweimer, J.; Schmitz, G.; Rogler, G.

World J. Gastroenterol.

13

5217-5225

690391

18784245

A new anti-loxoscelic serum produced against recombinant sphingomyelinase D: results of preclinical trials

2008

de Almeida, D.M.; Fernandes-Pedrosa, M.d.e..F.; de Andrade, R.M.; Marcelino, J.R.; Gondo-Higashi, H.; de Azevedo, I.d.e..L.; Ho, P.L.; van den Berg, C.; Tambourgi, D.V.

Am. J. Trop. Med. Hyg.

79

463-470

690455

19189644

Dietary sphingomyelin inhibits colonic tumorigenesis with an up-regulation of alkaline sphingomyelinase expression in ICR mice

2009

Zhang, P.; Li, B.; Gao, S.; Duan, R.D.

Anticancer Res.

28

3631-3635

690659

18772496

Lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells

2008

Jin, S.; Yi, F.; Zhang, F.; Poklis, J.L.; Li, P.L.

Arterioscler. Thromb. Vasc. Biol.

28

2056-2062

690664

18988890

Endothelial lipase promotes apolipoprotein AI-mediated cholesterol efflux in THP-1 macrophages

2009

Qiu, G.; Hill, J.S.

Arterioscler. Thromb. Vasc. Biol.

29

84-91

690667

18163502

Sphingomyelinase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signaling pathway

2008

Gilbert, S.J.; Blain, E.J.; Duance, V.C.; Mason, D.J.

Arthritis Rheum.

58

209-220

690903

18826261

Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis

2008

Montes, L.-R.; Lopez, D.J.; Sot, J.; Bagatolli, L.A.; Stonehouse, M.J.; Vasil, M.L.; Wu, B.X.; Hannun, Y.A.; Goni, F.M.; Alonso, A.

Biochemistry

47

11222-11230

691060

18675780

Effect of sphingomyelinase treatment on ligand binding activity of human serotonin1A receptors

2008

Jafurulla, M.; Pucadyil, T.J.; Chattopadhyay, A.

Biochim. Biophys. Acta

1778

2022-2025

691130

18760322

Nephrotoxicity caused by brown spider venom phospholipase-D (dermonecrotic toxin) depends on catalytic activity

2008

Kusma, J.; Chaim, O.M.; Wille, A.C.; Ferrer, V.P.; Sade, Y.B.; Donatti, L.; Gremski, W.; Mangili, O.C.; Veiga, S.S.

Biochimie

90

1722-1736

691456

18299447

Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias

2008

Kim, W.J.; Okimoto, R.A.; Purton, L.E.; Goodwin, M.; Haserlat, S.M.; Dayyani, F.; Sweetser, D.A.; McClatchey, A.I.; Bernard, O.A.; Look, A.T.; Bell, D.W.; Scadden, D.T.; Haber, D.A.

Blood

111

4716-4722

691696

18485117

Acid sphingomyelinase is required for efficient phago-lysosomal fusion

2008

Schramm, M.; Herz, J.; Haas, A.; Kroenke, M.; Utermoehlen, O.

Cell. Microbiol.

10

1839-1853

692009

18989780

Expression of alkaline sphingomyelinase in yeast cells and anti-inflammatory effects of the expressed enzyme in a rat colitis model

2008

Andersson, D.; Kotarsky, K.; Wu, J.; Agace, W.; Duan, R.D.

Digest. Dis. Sci.

54

1440-1448

692073

19300439

Acid sphingomyelinase activity triggers microparticle release from glial cells

2009

Bianco, F.; Perrotta, C.; Novellino, L.; Francolini, M.; Riganti, L.; Menna, E.; Saglietti, L.; Schuchman, E.H.; Furlan, R.; Clementi, E.; Matteoli, M.; Verderio, C.

EMBO J.

28

1043-1054

692236

19059399

Intracerebroventricular infusion of acid sphingomyelinase corrects CNS manifestations in a mouse model of Niemann-Pick A disease

2009

Dodge, J.C.; Clarke, J.; Treleaven, C.M.; Taksir, T.V.; Griffiths, D.A.; Yang, W.; Fidler, J.A.; Passini, M.A.; Karey, K.P.; Schuchman, E.H.; Cheng, S.H.; Shihabuddin, L.S.

Exp. Neurol.

215

349-357

692274

18567738

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases

2008

Smith, E.L.; Schuchman, E.H.

FASEB J.

22

3419-3431

693160

18678863

Identification of Mg2+-dependent neutral sphingomyelinase 1 as a mediator of heat stress-induced ceramide generation and apoptosis

2008

Yabu, T.; Imamura, S.; Yamashita, M.; Okazaki, T.

J. Biol. Chem.

283

29971-29982

693467

18768882

Acid sphingomyelinase amplifies redox signaling in Pseudomonas aeruginosa-induced macrophage apoptosis

2008

Zhang, Y.; Li, X.; Carpinteiro, A.; Gulbins, E.

J. Immunol.

181

4247-4254

693810

18955860

Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice

2008

Ohlsson, L.; Hjelte, L.; Huehn, M.; Scholte, B.J.; Wilke, M.; Flodstroem-Tullberg, M.; Nilsson, A.

J. Pediatr. Gastroenterol. Nutr.

47

547-554

693938

18671414

Effect of sphingomyelinase-mediated generation of ceramide on aggregation of low-density lipoprotein

2008

Walters, M.J.; Wrenn, S.P.

Langmuir

24

9642-9647

694095

19042943

Molecular evolution, functional variation, and proposed nomenclature of the gene family that includes sphingomyelinase D in sicariid spider venoms

2009

Binford, G.J.; Bodner, M.R.; Cordes, M.H.; Baldwin, K.L.; Rynerson, M.R.; Burns, S.N.; Zobel-Thropp, P.A.

Mol. Biol. Evol.

26

547-566

694111

18505924

Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies

2008

Corcoran, C.A.; He, Q.; Ponnusamy, S.; Ogretmen, B.; Huang, Y.; Sheikh, M.S.

Mol. Cancer Res.

6

795-807

694201

19231265

Pulmonary delivery of recombinant acid sphingomyelinase improves clearance of lysosomal sphingomyelin from the lungs of a murine model of Niemann-Pick disease

2009

Ziegler, R.J.; Brown, C.; Barbon, C.M.; DAngona, A.M.; Schuchman, E.H.; Andrews, L.; Thurberg, B.L.; McPherson, J.M.; Karey, K.P.; Cheng, S.H.

Mol. Genet. Metab.

97

35-42

694260

18653803

Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells

2008

Clarke, C.J.; Guthrie, J.M.; Hannun, Y.A.

Mol. Pharmacol.

74

1022-1032

694284

18628757

Acid sphingomyelinase overexpression enhances the antineoplastic effects of irradiation in vitro and in vivo

2008

Smith, E.L.; Schuchman, E.H.

Mol. Ther.

16

1565-1571

694904

18505843

Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo

2008

Henkes, L.E.; Sullivan, B.T.; Lynch, M.P.; Kolesnick, R.; Arsenault, D.; Puder, M.; Davis, J.S.; Rueda, B.R.

Proc. Natl. Acad. Sci. USA

105

7670-7675

695217

19249326

SMase II, a new sphingomyelinase D from Loxosceles laeta venom gland: Molecular cloning, expression, function and structural analysis

2009

de Santi Ferrara, G.I.; Fernandes-Pedrosa, M.D.; Junqueira-de-Azevedo, I.D.; Goncalves-de-Andrade, R.M.; Portaro, F.C.; Manzoni-de-Almeida, D.; Murakami, M.T.; Arni, R.K.; van den Berg, C.W.; Ho, P.L.; Tambourgi, D.V.

Toxicon

53

743-753

697594

19356099

Study of oxidized lipids as endogenous substrates of P-gp (ABCB1)

2008

Masuda, M.; Nakai, E.; Mizutani, T.

Drug Metab. Lett.

2

238-244

701641

18310483

Improved pulmonary function by acid sphingomyelinase inhibition in a newborn piglet lavage model

2008

von Bismarck, P.; Wistaedt, C.F.; Klemm, K.; Winoto-Morbach, S.; Uhlig, U.; Schuetze, S.; Adam, D.; Lachmann, B.; Uhlig, S.; Krause, M.F.

Am. J. Respir. Crit. Care Med.

177

1233-1241

702696

20005726

Development of carbohydrate-derived inhibitors of acid sphingomyelinase

2010

Roth, A.G.; Redmer, S.; Arenz, C.

Bioorg. Med. Chem.

18

939-944

703199

19688786

Potent inhibition of acid sphingomyelinase by phosphoinositide analogues

2009

Roth, A.G.; Redmer, S.; Arenz, C.

ChemBioChem

10

2367-2374

703346

19306528

Lecithin: cholesterol acyltransferase - from biochemistry to role in cardiovascular disease

2009

Rousset, X.; Vaisman, B.; Amar, M.; Sethi, A.; Remaley, A.

Curr. Opin. Endocrinol. Diabetes Obes.

16

163-171

703595

20138872

Entamoeba histolytica: Molecular cloning and characterization of a novel neutral sphingomyelinase

2010

Mendoza-Macias, C.L.; Barrios-Ceballos, M.P.; Anaya-Velazquez, F.; Nakada-Tsukui, K.; Nozaki, T.; Padilla-Vaca, F.

Exp. Parasitol.

125

279-285

704040

19084611

Hexadecylphosphocholine alters nonvesicular cholesterol traffic from the plasma membrane to the endoplasmic reticulum and inhibits the synthesis of sphingomyelin in HepG2 cells

2009

Marco, C.; Jimenez-Lopez, J.M.; Rios-Marco, P.; Segovia, J.L.; Carrasco, M.P.

Int. J. Biochem. Cell Biol.

41

1296-1303

704668

20378533

Identification and characterization of murine mitochondrial-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5

2010

Wu, B.X.; Rajagopalan, V.; Roddy, P.L.; Clarke, C.J.; Hannun, Y.A.

J. Biol. Chem.

285

17993-18002

704743

19716517

Purification, characterization, and gene cloning of sphingomyelinase C from Streptomyces griseocarneus NBRC13471

2009

Sugimori, D.

J. Biosci. Bioeng.

108

293-298

705258

19968763

Purification of neutral sphingomyelinase 2 from bovine brain and its calcium-dependent activation

2010

Kim, S.K.; Ahn, K.H.; Jeon, H.J.; Lee, D.H.; Jung, S.Y.; Jung, K.M.; Kim, D.K.

J. Neurochem.

112

1088-1097

705457

19951413

Boswellic acid inhibits expression of acid sphingomyelinase in intestinal cells

2009

Zhang, Y.; Duan, R.D.

Lipids Health Dis.

8

51

705473

19777283

Ezetimibe inhibits expression of acid sphingomyelinase in liver and intestine

2009

Cheng, Y.; Liu, F.; Wu, J.; Zhang, Y.; Nilsson, A.; Duan, R.D.

Lipids

44

897-906

706849

20144895

Comparative analyses of venoms from American and African Sicarius spiders that differ in sphingomyelinase D activity

2010

Zobel-Thropp, P.A.; Bodner, M.R.; Binford, G.J.

Toxicon

55

1274-1282

710455

20044023

Oxidized phosphatidylcholine stimulates activity of secretory phospholipase A2 group IIA and abolishes sphingomyelin-induced inhibition of the enzyme

2010

Korotaeva, A.A.; Samoilova, E.V.; Piksina, G.F.; Prokazova, N.V.

Prostaglandins Other Lipid Mediat.

91

38-41

714052

21256823

Acid sphingomyelinase regulates osteoclastogenesis by modulating sphingosine kinases downstream of RANKL signaling

2011

Bao, X.; Ogawa, T.; Se, S.; Akiyama, M.; Bahtiar, A.; Takeya, T.; Ishida-Kitagawa, N.

Biochem. Biophys. Res. Commun.

405

533-537

714335

21704605

Unexpected wide substrate specificity of C. perfringens alpha-toxin phospholipase C

2011

Urbina, P.; Collado, M.I.; Alonso, A.; Goni, F.M.; Flores-Diaz, M.; Alape-Giron, A.; Ruysschaert, J.M.; Lensink, M.F.

Biochim. Biophys. Acta

1808

2618-2627

714410

20627555

Synthesis and evaluation of novel phosphate ester analogs as neutral sphingomyelinase inhibitors

2010

Imagawa, H.; Oda, M.; Takemoto, T.; Yamauchi, R.; Yoshikawa, T.; Yamamoto, H.; Nishizawa, M.; Takahashi, H.; Hashimoto, M.; Yabiku, K.; Nagahama, M.; Sakurai, J.

Bioorg. Med. Chem. Lett.

20

3868-3871

714689

20501999

Small molecule inhibitors of acid sphingomyelinase

2010

Arenz, C.

Cell. Physiol. Biochem.

26

1-8

714926

20350542

Entamoeba histolytica: soluble and membrane-associated neutral sphingomyelinase-C and other unidentified esterase activity

2010

Vargas-Villarreal, J.; Palacios-Corona, R.; Hernandez-Luna, C.; Mata-Cardenas, B.D.; Torres de la Cruz, V.M.; Cortes-Gutierrez, E.I.; Gonzalez-Salazar, F.; Garza-Gonzalez, J.N.; Escobedo-Guajardo, B.L.; Said-Fernandez, S.

Exp. Parasitol.

125

394-399

715836

21252263

Imaging the early stages of phospholipase C/sphingomyelinase activity on vesicles containing coexisting ordered-disordered and gel-fluid domains

2011

Ibarguren, M.; Lopez, D.J.; Montes, L.R.; Sot, J.; Vasil, A.I.; Vasil, M.L.; Goni, F.M.; Alonso, A.

J. Lipid Res.

52

635-645

716252

20398210

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei

2010

Young, S.A.; Smith, T.K.

Mol. Microbiol.

76

1461-1482

716445

20430951

Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide

2010

Perrotta, C.; Clementi, E.

Physiology

25

64-71

716964

21236288

Determination of sphingomyelinase-D activity of Loxosceles venoms in sphingomyelin/cholesterol liposomes containing horseradish peroxidase

2011

Gomes, M.T.; Guimaraes, G.; Frezard, F.; Kalapothakis, E.; Minozzo, J.C.; Chaim, O.M.; Veiga, S.S.; Oliveira, S.C.; Chavez-Olortegui, C.

Toxicon

57

574-579

728914

25286953

Crystallization and preliminary X-ray diffraction analysis of a novel sphingomyelinase D from Loxosceles gaucho venom

2014

Ullah, A.; Magalhaes, G.S.; Masood, R.; Mariutti, R.B.; Coronado, M.A.; Murakami, M.T.; Barbaro, K.C.; Arni, R.K.

Acta Crystallogr. Sect. F

70

1418-1420

729101

22226857

Acidic sphingomyelinase induced by electrophiles promotes proinflammatory cytokine production in human bladder carcinoma ECV-304 cells

2012

Kumagai, T.; Ishino, T.; Nakagawa, Y.

Arch. Biochem. Biophys.

519

8-16

729131

22564743

Role of side-edge site of sphingomyelinase from Bacillus cereus

2012

Oda, M.; Takahashi, M.; Tsuge, H.; Nagahama, M.; Sakurai, J.

Biochem. Biophys. Res. Commun.

422

128-132

729132

23313504

Bacillus cereus sphingomyelinase recognizes ganglioside GM3

2013

Oda, M.; Fujita, A.; Okui, K.; Miyamoto, K.; Shibutani, M.; Takagishi, T.; Nagahama, M.

Biochem. Biophys. Res. Commun.

431

164-168

729171

25287744

Neutral sphingomyelinase-2 is a redox sensitive enzyme: role of catalytic cysteine residues in regulation of enzymatic activity through changes in oligomeric state

2015

Dotson Ii, P.P.; Karakashian, A.A.; Nikolova-Karakashian, M.N.

Biochem. J.

465

371-382

729609

24164338

Role of acid sphingomyelinase in the regulation of mast cell function

2014

Yang, W.; Schmid, E.; Nurbaeva, M.K.; Szteyn, K.; Leibrock, C.; Yan, J.; Schaller, M.; Gulbins, E.; Shumilina, E.; Lang, F.

Clin. Exp. Allergy

44

79-90

730060

25288789

Sphingomyelin phosphodiesterase-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages

2014

Traini, M.; Quinn, C.M.; Sandoval, C.; Johansson, E.; Schroder, K.; Kockx, M.; Meikle, P.J.; Jessup, W.; Kritharides, L.

J. Biol. Chem.

289

32895-32913

730073

22664344

Sphingomyelinase C from Streptomyces sp. A9107: unusual primary structure for bacterial sphingomyelinase C

2012

Sogabe, T.; Ota, H.; Iwasaki, M.; Sakasegawa, S.; Tamura, T.

J. Biosci. Bioeng.

114

398-401

730227

22441407

Structural analysis of the Leptospiral sphingomyelinases: in silico and experimental evaluation of Sph2 as an Mg++-dependent sphingomyelinase

2012

Narayanavari, S.A.; Kishore, N.M.; Sritharan, M.

J. Mol. Microbiol. Biotechnol.

22

24-34

730294

22573858

Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection

2012

Miller, M.E.; Adhikary, S.; Kolokoltsov, A.A.; Davey, R.A.

J. Virol.

86

7473-7483

730356

24694597

Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide

2014

He, Q.; Wang, G.; Wakade, S.; Dasgupta, S.; Dinkins, M.; Kong, J.N.; Spassieva, S.D.; Bieberich, E.

Mol. Biol. Cell

25

1715-1729

730694

22558155

Functional implications of novel human acid sphingomyelinase splice variants

2012

Rhein, C.; Tripal, P.; Seebahn, A.; Konrad, A.; Kramer, M.; Nagel, C.; Kemper, J.; Bode, J.; Muehle, C.; Gulbins, E.; Reichel, M.; Becker, C.M.; Kornhuber, J.

PLoS ONE

7

e35467

730697

22558302

Sphingomyelinase D activity in model membranes: structural effects of in situ generation of ceramide-1-phosphate

2012

Stock, R.P.; Brewer, J.; Wagner, K.; Ramos-Cerrillo, B.; Duelund, L.; Jernsh?j, K.D.; Olsen, L.F.; Bagatolli, L.A.

PLoS ONE

7

e36003

730731

23658784

Characterization of acid sphingomyelinase activity in human cerebrospinal fluid

2013

Muehle, C.; Huttner, H.B.; Walter, S.; Reichel, M.; Canneva, F.; Lewczuk, P.; Gulbins, E.; Kornhuber, J.

PLoS ONE

8

e62912

730746

24009677

Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates

2013

Lajoie, D.M.; Zobel-Thropp, P.A.; Kumirov, V.K.; Bandarian, V.; Binford, G.J.; Cordes, M.H.

PLoS ONE

8

e72372

730879

23201280

High-level over-expression, purification, and crystallization of a novel phospholipase C/sphingomyelinase from Pseudomonas aeruginosa

2013

Truan, D.; Vasil, A.; Stonehouse, M.; Vasil, M.L.; Pohl, E.

Protein Expr. Purif.

90

40-46

731005

24472346

Tryptophan and aspartic acid residues present in the glycerophosphoryl diester phosphodiesterase (GDPD) domain of the Loxosceles laeta phospholipase D are essential for substrate recognition

2014

Catalan, A.; Cortes, W.; Munoz, C.; Araya, J.E.

Toxicon

81

43-47

749181

27432949

Directed evolution of a sphingomyelin flippase reveals mechanism of substrate backbone discrimination by a P4-ATPase

2016

Roland, B.P.; Graham, T.R.

Proc. Natl. Acad. Sci. USA

113

E4460-E4466

749975

26976751

Recombinant broad-range phospholipase C from Listeria monocytogenes exhibits optimal activity at acidic pH

2016

Huang, Q.; Gershenson, A.; Roberts, M.F.

Biochim. Biophys. Acta

1864

697-705

750196

26690570

Adaptive evolution in the toxicity of a spiders venom enzymes

2015

Pedroso, A.; Matioli, S.R.; Murakami, M.T.; Pidde-Queiroz, G.; Tambourgi, D.V.

BMC Evol. Biol.

15

290

750264

26203857

Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses

2015

Bai, A.; Kokkotou, E.; Zheng, Y.; Robson, S.C.

Cell Death Dis.

6

e1828

750265

28358364

Functional inhibition of acid sphingomyelinase by fluphenazine triggers hypoxia-specific tumor cell death

2017

Klutzny, S.; Lesche, R.; Keck, M.; Kaulfuss, S.; Schlicker, A.; Christian, S.; Sperl, C.; Neuhaus, R.; Mowat, J.; Steckel, M.; Riefke, B.; Prechtl, S.; Parczyk, K.; Steigemann, P.

Cell Death Dis.

8

e2709

750288

28038894

Mechanistic characterization and inhibition of sphingomyelinase C over substituted Iron Schiff bases of chitosan adsorbed on glassy carbon electrode

2017

Caro, C.A.; Lillo, L.; Valenzuela, F.J.; Cabello, G.

Chem. Biol. Interact.

263

81-87

750737

28138018

Cellular uptake of Clostridium botulinum C2 toxin requires acid sphingomyelinase activity

2017

Nagahama, M.; Takehara, M.; Takagishi, T.; Seike, S.; Miyamoto, K.; Kobayashi, K.

Infect. Immun.

85

e00966-16

750742

30745329

Arcanobacterium haemolyticum utilizes both phospholipase D and arcanolysin to mediate its uptake into non-phagocytic cells

2019

Gellings, P.S.; McGee, D.J.

Infect. Immun.

87

e00832-18

750751

28374513

Identification and characterization of Laodelphax striatellus (Insecta Hemiptera Delphacidae) neutral sphingomyelinase

2017

Zhou, Y.; Lin, X.W.; Begum, M.A.; Zhang, C.H.; Shi, X.X.; Jiao, W.J.; Zhang, Y.R.; Yuan, J.Q.; Li, H.Y.; Yang, Q.; Mao, C.; Zhu, Z.R.

Insect Mol. Biol.

26

392-402

751069

27687724

Crystal structure of the acid sphingomyelinase-like phosphodiesterase SMPDL3B provides insights into determinants of substrate specificity

2016

Gorelik, A.; Heinz, L.X.; Illes, K.; Superti-Furga, G.; Nagar, B.

J. Biol. Chem.

291

24054-24064

751105

28292932

Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition

2017

Gorelik, A.; Liu, F.; Illes, K.; Nagar, B.

J. Biol. Chem.

292

7087-7094

751182

25716287

Sphingomyelin regulates the activity of secretory phospholipase A2 in the plasma membrane

2015

Nakamura, H.; Wakita, S.; Yasufuku, K.; Makiyama, T.; Waraya, M.; Hashimoto, N.; Murayama, T.

J. Cell. Biochem.

116

1898-1907

751183

27808444

Bacterial and arachnid sphingomyelinases D comparison of biophysical and pathological activities

2017

Mariutti, R.B.; Chaves-Moreira, D.; Vuitika, L.; Caruso, I.P.; Coronado, M.A.; Azevedo, V.A.; Murakami, M.T.; Veiga, S.S.; Arni, R.K.

J. Cell. Biochem.

118

2053-2063

751216

30734604

Targeting Loxosceles spider sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism

2019

Lopes, P.H.; Murakami, M.T.; Portaro, F.C.V.; Mesquita Pasqualoto, K.F.; van den Berg, C.; Tambourgi, D.V.

J. Enzyme Inhib. Med. Chem.

34

310-321

751246

26216860

Sphingomyelinase D inhibits store-operated Ca2+ entry in T lymphocytes by suppressing ORAI current

2015

Combs, D.J.; Lu, Z.

J. Gen. Physiol.

146

161-172

751328

27349982

Structure of human acid sphingomyelinase reveals the role of the saposin domain in activating substrate hydrolysis

2016

Xiong, Z.J.; Huang, J.; Poda, G.; Pomes, R.; Prive, G.G.

J. Mol. Biol.

428

3026-3042

751580

29257998

Loxosceles venom sphingomyelinase D activates human blood leukocytes Role of the complement system

2018

Manzoni-de-Almeida, D.; Squaiella-Baptistao, C.C.; Lopes, P.H.; van den Berg, C.W.; Tambourgi, D.V.

Mol. Immunol.

94

45-53

751655

27435900

Crystal structure of mammalian acid sphingomyelinase

2016

Gorelik, A.; Illes, K.; Heinz, L.X.; Superti-Furga, G.; Nagar, B.

Nat. Commun.

7

12196

751793

30392480

Substrate specificity of the neutral sphingomyelinase from Trypanosoma brucei

2018

Dickie, E.A.; Young, S.A.; Smith, T.K.

Parasitology

146

604-616

751945

27078876

Sphingomyelinase D from Loxosceles laeta venom induces the expression of MMP7 in human keratinocytes contribution to dermonecrosis

2016

Correa, M.A.; Okamoto, C.K.; Goncalves-de-Andrade, R.M.; van den Berg, C.W.; Tambourgi, D.V.

PLoS ONE

11

e0153090

752303

29882842

Arcanobacterium haemolyticum phospholipase D enzymatic activity promotes the hemolytic activity of the cholesterol-dependent cytolysin arcanolysin

2018

Gellings, P.S.; McGee, D.J.

Toxins

10

E213

752304

25938271

Sphingomyelinase D/ceramide 1-phosphate in cell survival and inflammation

2015

Rivera, I.G.; Ordonez, M.; Presa, N.; Gomez-Larrauri, A.; Simon, J.; Trueba, M.; Gomez-Munoz, A.

Toxins

7

1457-1466

752308

28335389

Characteristics and lethality of a novel recombinant dermonecrotic venom phospholipase D from Hemiscorpius lepturus

2017

Torabi, E.; Behdani, M.; Chafi, M.H.; Moazzami, R.; Sabatier, J.M.; Khalaj, V.; Shahbazzadeh, D.; Bagheri, K.P.

Toxins

9

E102

752317

27265457

Protective antibodies against a sphingomyelinase D from Loxosceles intermedia spider venom elicited in mice with different genetic background

2016

Oliveira, C.F.; Vilela, A.; Coura, L.A.; Rodrigues, F.T.; Nagem, R.A.; Chavez-Olortegui, C.; Maioli, T.U.; Felicori, L.F.

Vaccine

34

3828-3834

754363

26130766

A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production

2015

Huang, F.T.; Han, Y.B.; Feng, Y.; Yang, G.Y.

J. Lipid Res.

56

1836-1842