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CDP-diacylglycerol + D-myo-inositol
CMP + phosphatidyl-1D-myo-inositol
CDP-diheptadecanoylglycerol + D-myo-inositol
CMP + 1,2-diheptadecanoyl-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-dilinoleoylglycerol + D-myo-inositol
CMP + 1,2-dilinoleoyl-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-dioleoylglycerol + D-myo-inositol
CMP + 1,2-dioleoyl-phosphatidyl-1D-myo-inositol
highest activity, preferred in competition assay additionally containing 1,2-dipalmitoyl-, 1,2-dilinoleoyl-, and 1,2-diheptadecanoyl-CDP-diacylglycerol
-
-
?
CDP-dipalmitoylglycerol + D-myo-inositol
CMP + 1,2-dipalmitoyl-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-diacylglycerol + D-myo-inositol
CMP + phosphatidyl-1D-myo-inositol
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
CDP-diheptadecanoylglycerol + D-myo-inositol
CMP + 1,2-diheptadecanoyl-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-dilinoleoylglycerol + D-myo-inositol
CMP + 1,2-dilinoleoyl-phosphatidyl-1D-myo-inositol
highest activity, preferred in competition assay additionally containing 1,2-dipalmitoyl-, 1,2-dioleoyl-, and 1,2-diheptadecanoyl-CDP-diacylglycerol
-
-
?
CDP-dioleoylglycerol + D-myo-inositol
CMP + 1,2-dioleoyl-phosphatidyl-1D-myo-inositol
-
-
-
?
CDP-dipalmitoylglycerol + D-myo-inositol
CMP + 1,2-dipalmitoyl-phosphatidyl-1D-myo-inositol
-
-
-
?
additional information
?
-
CDP-diacylglycerol + D-myo-inositol
CMP + phosphatidyl-1D-myo-inositol
key step in lipid biosynthesis
-
-
?
CDP-diacylglycerol + D-myo-inositol
CMP + phosphatidyl-1D-myo-inositol
D-myo-inositol substrates: phosphatidylethanolamine, phosphatidic acid, overexpressed enzyme in bacterial membrane pellets, 30 min, 22°C, pH 8, 1% (v/v) Triton X-100, 20 mM MgCl2
fatty acid analysis by thin-layer chromatography
-
?
CDP-diacylglycerol + D-myo-inositol
CMP + phosphatidyl-1D-myo-inositol
key step in lipid biosynthesis
-
-
?
CDP-diacylglycerol + D-myo-inositol
CMP + phosphatidyl-1D-myo-inositol
D-myo-inositol substrates: phosphatidylethanolamine, phosphatidic acid, overexpressed enzyme in bacterial membrane pellets, 30 min, 22°C, pH 8, 1% (v/v) Triton X-100, 20 mM MgCl2
fatty acid analysis by thin-layer chromatography
-
?
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
CDP-diacylglycerol + myo-inositol
CMP + phosphatidyl-1D-myo-inositol
-
-
-
r
additional information
?
-
in transgenic plants, elevated formation of phosphatidic acid, phosphatidylinositol, phosphatidylethanolamine and diacylglycerol containing less polyunsaturated fatty acids but more saturated and monounsaturated fatty acids, no change in fatty acid composition of polyphopshoinositides compared to wild-type plants
-
-
?
additional information
?
-
in transgenic plants, elevated formation of phosphatidic acid, phosphatidylinositol, phosphatidylethanolamine and diacylglycerol containing less polyunsaturated fatty acids but more saturated and monounsaturated fatty acids, no change in fatty acid composition of polyphopshoinositides compared to wild-type plants
-
-
?
additional information
?
-
-
in transgenic plants, elevated formation of phosphatidic acid, phosphatidylinositol, phosphatidylethanolamine and diacylglycerol containing less polyunsaturated fatty acids but more saturated and monounsaturated fatty acids, no change in fatty acid composition of polyphopshoinositides compared to wild-type plants
-
-
?
additional information
?
-
moderate conversion of biological mixture of CDP-diacylglycerol substrates (synthesised from phosphatidylethanolamine in plant leaves) into phosphatidyl-1D-myo-inositol mainly containing palmitic acid and little linoleic acid, non-converted CDP-diacylglycerol residues containing linoleic acid and linolenic acid
-
-
?
additional information
?
-
moderate conversion of biological mixture of CDP-diacylglycerol substrates (synthesised from phosphatidylethanolamine in plant leaves) into phosphatidyl-1D-myo-inositol mainly containing palmitic acid and little linoleic acid, non-converted CDP-diacylglycerol residues containing linoleic acid and linolenic acid
-
-
?
additional information
?
-
-
moderate conversion of biological mixture of CDP-diacylglycerol substrates (synthesised from phosphatidylethanolamine in plant leaves) into phosphatidyl-1D-myo-inositol mainly containing palmitic acid and little linoleic acid, non-converted CDP-diacylglycerol residues containing linoleic acid and linolenic acid
-
-
?
additional information
?
-
preference of C18-fatty acid CDP-diacylglycerol substrates
-
-
?
additional information
?
-
preference of C18-fatty acid CDP-diacylglycerol substrates
-
-
?
additional information
?
-
-
preference of C18-fatty acid CDP-diacylglycerol substrates
-
-
?
additional information
?
-
-
enzyme also catalyzes diacylglycerol-independent exchange reaction between phosphatidylinositol and inositol
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-
?
additional information
?
-
highly efficient conversion of biological mixture of CDP-diacylglycerol substrates (synthesised from phosphatidylethanolamine in plant leaves) into phosphatidyl-1D-myo-inositol mainly containing palmitic, acid linoleic acid and linolenic acid, complete conversion of CDP-diacylglycerol residues containing palmitic, acid linoleic acid and linolenic acid
-
-
?
additional information
?
-
highly efficient conversion of biological mixture of CDP-diacylglycerol substrates (synthesised from phosphatidylethanolamine in plant leaves) into phosphatidyl-1D-myo-inositol mainly containing palmitic, acid linoleic acid and linolenic acid, complete conversion of CDP-diacylglycerol residues containing palmitic, acid linoleic acid and linolenic acid
-
-
?
additional information
?
-
-
highly efficient conversion of biological mixture of CDP-diacylglycerol substrates (synthesised from phosphatidylethanolamine in plant leaves) into phosphatidyl-1D-myo-inositol mainly containing palmitic, acid linoleic acid and linolenic acid, complete conversion of CDP-diacylglycerol residues containing palmitic, acid linoleic acid and linolenic acid
-
-
?
additional information
?
-
in transgenic plants, elevated formation of phosphatidic acid, phosphatidylinositol, and polyphosphoinositide (PtdIns(4,5)P, PtdIns(4,5)P2) that are enriched in polyunsaturated fatty acids compared to wild-type plants
-
-
?
additional information
?
-
in transgenic plants, elevated formation of phosphatidic acid, phosphatidylinositol, and polyphosphoinositide (PtdIns(4,5)P, PtdIns(4,5)P2) that are enriched in polyunsaturated fatty acids compared to wild-type plants
-
-
?
additional information
?
-
-
in transgenic plants, elevated formation of phosphatidic acid, phosphatidylinositol, and polyphosphoinositide (PtdIns(4,5)P, PtdIns(4,5)P2) that are enriched in polyunsaturated fatty acids compared to wild-type plants
-
-
?
additional information
?
-
preference of polyansaturated C18-fatty acid CDP-diacylglycerol substrates
-
-
?
additional information
?
-
preference of polyansaturated C18-fatty acid CDP-diacylglycerol substrates
-
-
?
additional information
?
-
-
preference of polyansaturated C18-fatty acid CDP-diacylglycerol substrates
-
-
?
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Xue, H.W.; Hosaka, K.; Plesch, G.; Mueller-Roeber, B.
Cloning of Arabidopsis thaliana phosphatidylinositol synthase and functional expression in the yeast pis mutant
Plant Mol. Biol.
42
757-764
2000
Arabidopsis thaliana, Arabidopsis thaliana (Q8GUK6), no activity in Saccharomyces cerevisiae
brenda
Justin, A.M.; Kader, J.C.; Collin, S.
Phosphatidylinositol synthesis and exchange of the inositol head are catalysed by the single phosphatidylinositol synthase 1 from Arabidopsis
Eur. J. Biochem.
269
2347-2352
2002
Arabidopsis thaliana, no activity in Escherichia coli
brenda
Justin, A.M.; Kader, J.C.; Collin, S.
Synthetic capacity of Arabidopsis phosphatidylinositol synthase 1 expressed in Escherichia coli
Biochim. Biophys. Acta
1634
52-60
2003
Arabidopsis thaliana
brenda
Loefke, C.; Ischebeck, T.; Koenig, S.; Freitag, S.; Heilmann, I.
Alternative metabolic fates of phosphatidylinositol produced by phosphatidylinositol synthase isoforms in Arabidopsis thaliana
Biochem. J.
413
115-124
2008
Arabidopsis thaliana (Q8GUK6), Arabidopsis thaliana (Q8LBA6), Arabidopsis thaliana
brenda