Ligand CDP-diacylglycerol

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Basic Ligand Information

Molecular Structure
Picture of CDP-diacylglycerol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H31N3O15P2R2
CDP-diacylglycerol
Synonyms:
a CDP-diacylglycerol, CDP-1,2-diacyl-sn-glycerol, CDP-1,2-diacylglycerol, CDP-diacylglycerols, CDPdiacylglycerol


Show all pahtways known for Show all BRENDA pathways known for CDP-diacylglycerol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
diphosphate + CDP-diacylglycerol = CTP + phosphatidate
-
show the reaction diagram
CDP-diacylglycerol + choline = CMP + phosphatidylcholine
-
show the reaction diagram
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate = CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
show the reaction diagram
CDPdiacylglycerol + H2O = CMP + phosphatidate
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
diphosphate + CDP-diacylglycerol = CTP + phosphatidate
-
show the reaction diagram
CDP-diacylglycerol + choline = CMP + phosphatidylcholine
-
show the reaction diagram
CDP-1,2-diacylglycerol + L-serine = CMP + 1,2-diacyl-sn-glycero-3-phospho-L-serine
-
show the reaction diagram
CDP-diacylglycerol + 1L-myo-inositol 1-phosphate = CMP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
show the reaction diagram
CDPdiacylglycerol + H2O = CMP + phosphatidate
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
CMP + 1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate = CDP-diacylglycerol + sn-glycerol 3-phosphate
-

Activator in Enzyme-catalyzed Reactions (2 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (9 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
above 0.4 mM
-
above 0.5 mM
-
inhibition of CDP-diacylglycerol formation
-
uncompetitive at high concentration
-
mixed inhibition mechanism
-

Enzyme Kinetic Parameters

KM Value (20 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
-
0.036
-
pH 9.0, 37°C
0.036
-
pH 8.6, 37°C
0.0095
-
pH 8.5, 37°C
pH 8.0, 30°C
0.01
-
pH 7.5, 37°C
0.21
-
?
0.07
-
30°C, pH 8.5, isozyme PGPS2
0.017
-
37°C, pH 7.4
0.288
-
37°C, pH 8.0
0.046
-
30°C, pH 8.5, isozyme PGPS1
0.012
-
pH 7.0, 30°C
0.046
-
30°C, pH 8.0
0.046
-
pH 7.5, 37°C
0.043
-

References & Links

Links to other databases for CDP-diacylglycerol

ChEBI
PubChem
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