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Information on EC 2.7.11.25 - mitogen-activated protein kinase kinase kinase

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IUBMB Comments
This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) but requires MAPKKKK for activation. Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway . Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
(JNK)/stress-activated protein kinase-associated protein 1, A-Raf, angle1, apoptosis signal-regulated kinase 1, apoptosis signal-regulating kinase, apoptosis signal-regulating kinase 1, apoptosis signal-regulating kinase 2, ASK1, ASK2, At4g08480, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
ATP + a protein = ADP + a phosphoprotein
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