EC Number   |
Activating Compound |
Reference |
|---|
   2.7.11.25 | CpG |
ASK1, TAK1, MEKK3 |
682954 |
| 2.7.11.25 | GADD45 protein |
- |
761109 |
| 2.7.11.25 | Gadd45alpha |
causes an increase in the activation of both the p38 and JNK pathways, but not the ERK pathway, upregulates MEKK4s kinase activity to a lesser degree as compared to Gadd45beta or Gadd45gamma |
681023 |
| 2.7.11.25 | Gadd45beta |
causes an increase in the activation of both the p38 and JNK pathways, but not the ERK pathway |
681023 |
| 2.7.11.25 | Gadd45gamma |
causes an increase in the activation of both the p38 and JNK pathways, but not the ERK pathway |
681023 |
| 2.7.11.25 | GTPAse Rac1 |
interacts with MLK2, the enzyme contains a G-protein binding domain, i.e. a CRIB domain |
664712 |
| 2.7.11.25 | H2O2 |
activates, MEKK1 kinase activity and protein stability is regulated by H2O2 in a proteasome-dependent manner |
680726 |
| 2.7.11.25 | H2O2 |
ASK1 |
682954 |
| 2.7.11.25 | H2O2 |
oxidative stress activates OMTK1 |
665503 |
| 2.7.11.25 | H2O2 |
phosphorylation of ASK2 at Thr807 increases in response to H2O2 in cells co-expressing ASK2 and a ASK1 kinase-negative mutant, whereas singly expressed ASK2 does not respond to H2O2. ASK2 kinase-negative mutant co-expressed with ASK1 kinase-negative mutant is not phosphorylated at Thr807 irrespective of the H2O2 treatment |
680887 |
