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Information on EC 2.7.1.94 - acylglycerol kinase and Organism(s) Mus musculus and UniProt Accession Q9ESW4

for references in articles please use BRENDA:EC2.7.1.94
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EC Tree
IUBMB Comments
Acts on both 1- and 2-acylglycerols.
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This record set is specific for:
Mus musculus
UNIPROT: Q9ESW4
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
tim22 complex, acylglycerol kinase, 1-mgk, 2-mgk, monoacylglycerol kinase, monoglyceride kinase, 1-monoacylglycerol kinase, multisubstrate lipid kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acylglycerol kinase
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kinase, monoacylglycerol (phosphorylating)
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-
-
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MGK
-
-
-
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monoacylglycerol kinase
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-
-
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monoglyceride kinase
-
-
-
-
monoglyceride phosphokinase
-
-
-
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sn-2-monoacylglycerol kinase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
ATP:acylglycerol 3-phosphotransferase
Acts on both 1- and 2-acylglycerols.
CAS REGISTRY NUMBER
COMMENTARY hide
62213-37-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + acylglycerol
ADP + acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
?
ATP + monoacylglycerol
ADP + lysophosphatidic acid
show the reaction diagram
-
-
-
?
ATP + PTEN protein
ADP + phosphorylated PTEN protein
show the reaction diagram
-
-
-
?
ATP + diacylglycerol
ADP + phosphatidic acid
show the reaction diagram
-
-
i.e. diacyl-glycerol 3-phosphate
-
?
ATP + monoacylglycerol
ADP + lysophosphatidic acid
show the reaction diagram
-
-
i.e. acyl-sn-glycerol 3-phosphate
-
?
additional information
?
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-
the enzyme modulates cross talk with EGFR in prostate cancer cells, enzyme regulates the synthesis of the bioactive phospholipids lysophosphatidic acid and phosphatidic acid, activation of extracellular signal related kinase 1 and 2, thus being involved in pathenogenesis of cancer via enhanced cell proliferation
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + acylglycerol
ADP + acyl-sn-glycerol 3-phosphate
show the reaction diagram
-
-
-
?
ATP + monoacylglycerol
ADP + lysophosphatidic acid
show the reaction diagram
-
-
-
?
additional information
?
-
-
the enzyme modulates cross talk with EGFR in prostate cancer cells, enzyme regulates the synthesis of the bioactive phospholipids lysophosphatidic acid and phosphatidic acid, activation of extracellular signal related kinase 1 and 2, thus being involved in pathenogenesis of cancer via enhanced cell proliferation
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
required
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.2
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme is required for CD8+ T cell expansion, antitumor function and regulates CD8+ T cell glycolysis and activation of phosphatidylinositol-3-OH kinase-mammalian target of rapamycin. Enzyme-triggered PTEN inactivation promotes a CD8+ T cell metabolic switch
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
AGK_MOUSE
421
0
46976
Swiss-Prot
Secretory Pathway (Reliability: 5)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant murine His6-tagged enzyme AGK from COS-7 cells by nickel affinity chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant expression of His6-tagged enzyme AGK from vector pSF-CMV-NH2-His-EKT3 in COS-7 cells
DNA and amino acid sequence determination and analysis
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bektas, M.; Payne, S.G.; Liu, H.; Goparaju, S.; Milstien, S.; Spiegel, S.
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells
J. Cell. Biol.
169
801-811
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Sato, Y.; Murakami, C.; Yamaki, A.; Mizuno, S.; Sakai, H.; Sakane, F.
Distinct 1-monoacylglycerol and 2-monoacylglycerol kinase activities of diacylglycerol kinase isozymes
Biochim. Biophys. Acta
1864
1170-1176
2016
Homo sapiens, Mus musculus (Q9ESW4), Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Hu, Z.; Qu, G.; Yu, X.; Jiang, H.; Teng, X.L.; Ding, L.; Hu, Q.; Guo, X.; Zhou, Y.; Wang, F.; Li, H.B.; Chen, L.; Jiang, J.; Su, B.; Liu, J.; Zou, Q.
Acylglycerol kinase maintains metabolic state and immune responses of CD8+ T cells
Cell Metab.
30
290-302.e5
2019
Mus musculus (Q9ESW4)
Manually annotated by BRENDA team