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Literature summary for 2.7.1.94 extracted from

  • Hu, Z.; Qu, G.; Yu, X.; Jiang, H.; Teng, X.L.; Ding, L.; Hu, Q.; Guo, X.; Zhou, Y.; Wang, F.; Li, H.B.; Chen, L.; Jiang, J.; Su, B.; Liu, J.; Zou, Q.
    Acylglycerol kinase maintains metabolic state and immune responses of CD8+ T cells (2019), Cell Metab., 30, 290-302.e5 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + monoacylglycerol Mus musculus
-
 ADP + lysophosphatidic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9ESW4
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:CD8+ cell
-
 Mus musculus
-
T-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + monoacylglycerol
-
 Mus musculus ADP + lysophosphatidic acid
-
 ?
ATP + PTEN protein
-
 Mus musculus ADP + phosphorylated PTEN protein
-
 ?

Synonyms

Synonyms Comment Organism
AGK
-
 Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme is required for CD8+ T cell expansion, antitumor function and regulates CD8+ T cell glycolysis and activation of phosphatidylinositol-3-OH kinase-mammalian target of rapamycin. Enzyme-triggered PTEN inactivation promotes a CD8+ T cell metabolic switch Mus musculus