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Information on EC 2.7.1.202 - protein-Npi-phosphohistidine-D-fructose phosphotransferase

for references in articles please use BRENDA:EC2.7.1.202
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IUBMB Comments
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is usually a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). The enzyme from the bacterium Escherichia coli is an exception, since it is phosphorylated directly by EC 2.7.3.9. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
fructose carrier, enzyme iifru, fructose-specific pts, iiblev, eiifru, fructose permease, fructose-specific enzyme ii, f-pts, fructose-specific phosphotransferase system, iifru, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[protein]-Npi-phospho-L-histidine + D-fructose[side 1] = [protein]-L-histidine + D-fructose 1-phosphate[side 2]
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