Literature summary for 2.7.1.202 extracted from

Lin, D.; Fan, J.; Wang, J.; Liu, L.; Xu, L.; Li, F.; Yang, J.; Li, B.
The fructose-specific phosphotransferase system of Klebsiella pneumoniae is regulated by global regulator CRP and linked to virulence and growth (2018), Infect. Immun., 86, e00340-18 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Klebsiella pneumoniae	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[protein]-Npi-phospho-L-histidine + D-fructose[side 1]	Klebsiella pneumoniae	-	[protein]-L-histidine + D-fructose 1-phosphate[side 2]	-	?
[protein]-Npi-phospho-L-histidine + D-fructose[side 1]	Klebsiella pneumoniae NTUH-2044	-	[protein]-L-histidine + D-fructose 1-phosphate[side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Klebsiella pneumoniae	-	-	-
Klebsiella pneumoniae NTUH-2044	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[protein]-Npi-phospho-L-histidine + D-fructose[side 1]	-	Klebsiella pneumoniae	[protein]-L-histidine + D-fructose 1-phosphate[side 2]	-	?
[protein]-Npi-phospho-L-histidine + D-fructose[side 1]	-	Klebsiella pneumoniae NTUH-2044	[protein]-L-histidine + D-fructose 1-phosphate[side 2]	-	?

Synonyms

Synonyms	Comment	Organism
fructose-specific enzyme IIC	-	Klebsiella pneumoniae
fructose-specific phosphotransferase system	-	Klebsiella pneumoniae
frwC	-	Klebsiella pneumoniae

General Information

General Information	Comment	Organism
malfunction	enzyme gene frwC deletion can enhance biofilm formation and capsular polysaccharide biosynthesis but decreases the growth rate and lethality in mice	Klebsiella pneumoniae
physiological function	frwC gene expression is controlled by cyclic AMP receptor protein directly and that such regulation contributes to bacterial growth, capsular polysaccharide synthesis, and the virulence of the cyclic AMP receptor protein-deficient strain	Klebsiella pneumoniae

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Release 2023.1 (January 2023)