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Ligand protein-L-histidine

Basic Ligand Information

Molecular Structure

Related pathways

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.B157

[protein]-L-histidine + S-adenosyl-L-methionine = [protein]-N1-methyl-L-histidine + S-adenosyl-L-homocysteine

776951

-

2.7.1.197

[protein]-L-histidine + D-mannitol 1-phosphate[side 2] = [protein]-Npi-phospho-L-histidine + D-mannitol[side 1]

641866

-

2.7.13.3

GTP + protein-L-histidine = GDP + protein N-phospho-L-histidine

692901

-

In Vivo Product in Enzyme-catalyzed Reactions (28 results)

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Show Natural Product (28 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.191

[protein]-Npi-phospho-L-histidine + 2-deoxy-D-glucose[side 1] = [protein]-L-histidine + 2-deoxy-D-glucose 6-phosphate[side 2]

-

-

2.7.1.191

[protein]-Npi-phospho-L-histidine + D-fructose[side 1] = [protein]-L-histidine + D-fructose 6-phosphate[side 2]

-

-

2.7.1.191

[protein]-Npi-phospho-L-histidine + D-glucosaminate[side 1] = [protein]-L-histidine + D-glucosaminate 6-phosphate[side 2]

-

-

2.7.1.191

[protein]-Npi-phospho-L-histidine + D-glucose[side 1] = [protein]-L-histidine + D-glucose 6-phosphate[side 2]

-

-

2.7.1.191

[protein]-Npi-phospho-L-histidine + D-mannose[side 1] = [protein]-L-histidine + D-mannose 6-phosphate[side 2]

-

-

2.7.1.191

5 entries

2.7.1.192

[protein]-Npi-phospho-L-histidine + N-acetylmuramate[side 1] = [protein]-L-histidine + N-acetylmuramate 6-phosphate[side 2]

-

-

2.7.1.193

[protein]-Npi-phospho-L-histidine + N-acetyl-D-glucosamine[side 1] = [protein]-L-histidine + N-acetyl-D-glucosamine 6-phosphate[side2]

-

-

2.7.1.194

[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1] = [protein]-L-histidine + L-ascorbate 6-phosphate[side 2]

-

-

2.7.1.195

[protein]-Npi-phospho-L-histidine + 2-O-alpha-mannosyl-D-glycerate [side 1] = [protein]-L-histidine + 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate [side 2]

-

-

2.7.1.196

[protein]-Npi-phospho-L-histidine + N,N'-diacetylchitobiose[side 1] = [protein]-L-histidine + N,N'-diacetylchitobiose 6'-phosphate[side 2]

-

-

2.7.1.197

[protein]-Npi-phospho-L-histidine + D-mannitol[side 1] = [protein]-L-histidine + D-mannitol 1-phosphate[side 2]

-

-

2.7.1.199

[protein]-Npi-phospho-L-histidine + D-glucose[side 1] = [protein]-L-histidine + D-glucose 6-phosphate[side 2]

-

-

2.7.1.199

[protein]-Npi-phospho-L-histidine + methyl alpha-D-glucoside[side 1] = [protein]-L-histidine + methyl alpha-D-glucose 6-phosphate[side 2]

-

-

2.7.1.199

2 entries

2.7.1.200

[protein]-Npi-phospho-L-histidine + galactitol[side 1] = [protein]-L-histidine + galactitol 1-phosphate[side 2]

-

-

2.7.1.201

[protein]-Npi-phospho-L-histidine + alpha,alpha-trehalose[side 1] = [protein]-L-histidine + alpha,alpha-trehalose 6-phosphate[side 2]

-

-

2.7.1.202

[protein]-Npi-phospho-L-histidine + D-fructose[side 1] = [protein]-L-histidine + D-fructose 1-phosphate[side 2]

-

-

2.7.1.203

[protein]-Npi-phospho-L-histidine + 2-amino-2-deoxy-D-gluconate[side 1] = [protein]-L-histidine + 2-amino-2-deoxy-D-gluconate 6-phosphate[side 2]

-

-

2.7.1.204

[protein]-Npi-phospho-L-histidine + D-galactose[side 1] = [protein]-L-histidine + D-galactose 6-phosphate[side 2]

-

-

2.7.1.205

[protein]-Npi-phospho-L-histidine + cellobiose[side 1] = [protein]-L-histidine + 6-phospho-beta-D-glucosyl-(1->4)-D-glucose[side 2]

-

-

2.7.1.205

[protein]-Npi-phospho-L-histidine + D-cellobiose[side 1] = [protein]-L-histidine + D-cellobiose 6'-phosphate[side 2]

-

-

2.7.1.205

2 entries

2.7.1.206

[protein]-Npi-phospho-L-histidine + L-sorbose[side 1] = [protein]-L-histidine + L-sorbose 1-phosphate[side 2]

-

-

2.7.1.207

[protein]-Npi-phospho-L-histidine + isopropyl beta-D-1-thiogalactopyranoside[side 1] = [protein]-L-histidine + isopropyl beta-D-1-thiogalactopyranose 6'-phosphate[side 2]

-

-

2.7.1.207

[protein]-Npi-phospho-L-histidine + lactose[side 1] = [protein]-L-histidine + lactose 6'-phosphate[side 2]

-

-

2.7.1.208

[protein]-Npi-phospho-L-histidine + maltose[side 1] = [protein]-L-histidine + maltose 6'-phosphate[side 2]

-

-

2.7.1.208

[protein]-Npi-phospho-L-histidine + maltotriose[side 1] = [protein]-L-histidine + maltotriose 6''-phosphate[side 2]

-

-

2.7.1.207

2 entries

2.7.1.208

2 entries

2.7.1.211

[protein]-Npi-phospho-L-histidine + sucrose[side 1] = [protein]-L-histidine + sucrose 6'-phosphate[side 2]

-

-

3.9.1.3

a [protein]-N-phospho-L-histidine + H2O = a [protein]-L-histidine + phosphate

-

-

3.9.1.3

[protein]-N-phospho-L-histidine + H2O = [protein]-L-histidine + phosphate

-

-

3.9.1.3

2 entries

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.B157

[protein]-L-histidine + S-adenosyl-L-methionine = [protein]-N1-methyl-L-histidine + S-adenosyl-L-homocysteine

776951, 778682, 776953

-

2.7.1.197

[protein]-L-histidine + D-mannitol 1-phosphate[side 2] = [protein]-Npi-phospho-L-histidine + D-mannitol[side 1]

641866

-

2.7.13.3

GTP + protein-L-histidine = GDP + protein N-phospho-L-histidine

692901

-

Product in Enzyme-catalyzed Reactions (43 results)

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Show Product (43 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.191

[protein]-Npi-phospho-L-histidine + 2-deoxy-D-glucose [side 1] = [protein]-L-histidine + 2-deoxy-D-glucose 6-phosphate[side 2]

-

-

2.7.1.191

[protein]-Npi-phospho-L-histidine + 2-deoxy-D-glucose[side 1] = [protein]-L-histidine + 2-deoxy-D-glucose 6-phosphate[side 2]

-

-

2.7.1.191

[protein]-Npi-phospho-L-histidine + 2-deoxyglucose[side 1] = [protein]-L-histidine + 2-deoxyglucose 6-phosphate[side 2]

-

-

2.7.1.191

[protein]-Npi-phospho-L-histidine + D-fructose[side 1] = [protein]-L-histidine + D-fructose 6-phosphate[side 2]

-

-

2.7.1.191

[protein]-Npi-phospho-L-histidine + D-glucosaminate[side 1] = [protein]-L-histidine + D-glucosaminate 6-phosphate[side 2]

-

-

2.7.1.191

[protein]-Npi-phospho-L-histidine + D-glucose[side 1] = [protein]-L-histidine + D-glucose 6-phosphate[side 2]

-

-

2.7.1.191

[protein]-Npi-phospho-L-histidine + D-mannose[side 1] = [protein]-L-histidine + D-mannose 6-phosphate[side 2]

-

-

2.7.1.191

[protein]-Npi-phospho-L-histidine + N-acetyl-D-glucosamine [side 1] = [protein]-L-histidine + N-acetyl-D-glucosamine 6-phosphate[side 2]

-

-

2.7.1.191

8 entries

2.7.1.192

[protein]-Npi-phospho-L-histidine + N-acetylmuramate[side 1] = [protein]-L-histidine + N-acetylmuramate 6-phosphate[side 2]

-

-

2.7.1.193

[protein]-Npi-phospho-L-histidine + N-acetyl-D-glucosamine[side 1] = [protein]-L-histidine + N-acetyl-D-glucosamine 6-phosphate[side2]

-

-

2.7.1.194

[protein]-Npi-phospho-L-histidine + L-ascorbate[side 1] = [protein]-L-histidine + L-ascorbate 6-phosphate[side 2]

-

-

2.7.1.195

[protein]-Npi-phospho-L-histidine + 2-O-alpha-mannosyl-D-glycerate [side 1] = [protein]-L-histidine + 2-O-(6-phospho-alpha-D-mannosyl)-D-glycerate [side 2]

-

-

2.7.1.196

[protein]-Npi-phospho-L-histidine + N,N'-diacetylchitobiose[side 1] = [protein]-L-histidine + N,N'-diacetylchitobiose 6'-phosphate[side 2]

-

-

2.7.1.197

[protein]-Npi-phospho-L-histidine + 2-amino-2-deoxy-D-mannitol[side 1] = [protein]-L-histidine + 2-amino-2-deoxy-D-mannitol 1-phosphate[side 2]

-

-

2.7.1.197

[protein]-Npi-phospho-L-histidine + 2-deoxy-D-mannitol[side 1] = [protein]-L-histidine + 2-deoxy-D-mannitol 1-phosphate[side 2]

-

-

2.7.1.197

[protein]-Npi-phospho-L-histidine + D-arabitol[side 1] = [protein]-L-histidine + D-arabitol 1-phosphate[side 2]

-

-

2.7.1.197

[protein]-Npi-phospho-L-histidine + D-glucitol[side 1] = [protein]-L-histidine + D-glucitol 1-phosphate[side 2]

-

-

2.7.1.197

[protein]-Npi-phospho-L-histidine + D-mannitol[side 1] = [protein]-L-histidine + D-mannitol 1-phosphate[side 2]

-

-

2.7.1.199

[protein]-Npi-phospho-L-histidine + 2-deoxy-D-glucose[side 1] = [protein]-L-histidine + 2-deoxy-D-glucose 6-phosphate[side 2]

-

-

2.7.1.199

[protein]-Npi-phospho-L-histidine + D-fructose[side 1] = [protein]-L-histidine + D-fructose 6-phosphate[side 2]

-

-

2.7.1.199

[protein]-Npi-phospho-L-histidine + D-glucose[side 1] = [protein]-L-histidine + D-glucose 6-phosphate[side 2]

-

-

2.7.1.199

[protein]-Npi-phospho-L-histidine + D-mannose[side 1] = [protein]-L-histidine + D-mannose 6-phosphate[side 2]

-

-

2.7.1.199

[protein]-Npi-phospho-L-histidine + methyl alpha-D-glucopyranoside = [protein]-L-histidine + methyl alpha-D-glucopyranoside 6-phosphate

-

-

2.7.1.199

[protein]-Npi-phospho-L-histidine + methyl alpha-D-glucoside[side 1] = [protein]-L-histidine + methyl alpha-D-glucose 6-phosphate[side 2]

-

-

2.7.1.199

[protein]-Npi-phospho-L-histidine + methyl alpha-glucoside[side 1] = [protein]-L-histidine + methyl alpha-glucoside 6-phosphate[side 2]

-

-

2.7.1.200

[protein]-Npi-phospho-L-histidine + D-glucitol[side 1] = [protein]-L-histidine + D-glucitol 1-phosphate[side 2]

-

-

2.7.1.200

[protein]-Npi-phospho-L-histidine + galactitol[side 1] = [protein]-L-histidine + galactitol 1-phosphate[side 2]

-

-

2.7.1.197

5 entries

2.7.1.199

7 entries

2.7.1.200

2 entries

2.7.1.201

[protein]-Npi-phospho-L-histidine + alpha,alpha-trehalose[side 1] = [protein]-L-histidine + alpha,alpha-trehalose 6-phosphate[side 2]

-

-

2.7.1.202

[protein]-Npi-phospho-L-histidine + D-fructose[side 1] = [protein]-L-histidine + D-fructose 1-phosphate[side 2]

-

-

2.7.1.203

[protein]-Npi-phospho-L-histidine + 2-amino-2-deoxy-D-gluconate[side 1] = [protein]-L-histidine + 2-amino-2-deoxy-D-gluconate 6-phosphate[side 2]

-

-

2.7.1.204

[protein]-Npi-phospho-L-histidine + D-galactose[side 1] = [protein]-L-histidine + D-galactose 6-phosphate[side 2]

-

-

2.7.1.205

[protein]-Npi-phospho-L-histidine + cellobiose[side 1] = [protein]-L-histidine + 6-phospho-beta-D-glucosyl-(1->4)-D-glucose[side 2]

-

-

2.7.1.205

[protein]-Npi-phospho-L-histidine + D-cellobiose[side 1] = [protein]-L-histidine + D-cellobiose 6'-phosphate[side 2]

-

-

2.7.1.205

2 entries

2.7.1.206

[protein]-Npi-phospho-L-histidine + L-sorbose[side 1] = [protein]-L-histidine + L-sorbose 1-phosphate[side 2]

-

-

2.7.1.207

[protein]-Npi-phospho-L-histidine + 4-nitrophenyl beta-D-galactoside[side 1] = [protein]-L-histidine + 4-nitrophenyl beta-D-galactoside 6'-phosphate[side 2]

-

-

2.7.1.207

[protein]-Npi-phospho-L-histidine + isopropyl beta-D-1-thiogalactopyranoside[side 1] = [protein]-L-histidine + isopropyl beta-D-1-thiogalactopyranose 6'-phosphate[side 2]

-

-

2.7.1.207

[protein]-Npi-phospho-L-histidine + lactose[side 1] = [protein]-L-histidine + lactose 6'-phosphate[side 2]

-

-

2.7.1.208

[protein]-Npi-phospho-L-histidine + maltose[side 1] = [protein]-L-histidine + maltose 6'-phosphate[side 2]

-

-

2.7.1.208

[protein]-Npi-phospho-L-histidine + maltotriose[side 1] = [protein]-L-histidine + maltotriose 6''-phosphate[side 2]

-

-

2.7.1.211

[protein]-Npi-phospho-L-histidine + sucrose[side 1] = [protein]-L-histidine + sucrose 6'-phosphate[side 2]

-

-

2.7.1.211

[protein]-Npi-phospho-L-histidine + sucrose[side 1] = [protein]-L-histidine + sucrose 6G-phosphate[side 2]

-

-

3.9.1.3

a [protein]-N-phospho-L-histidine + H2O = a [protein]-L-histidine + phosphate

-

-

3.9.1.3

[protein]-N-phospho-L-histidine + H2O = [protein]-L-histidine + phosphate

-

-

2.7.1.207

3 entries

2.7.1.208

2 entries

2.7.1.211

2 entries

3.9.1.3

2 entries

Enzyme Kinetic Parameters

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

641866

6350293

Mannitol-specific enzyme II of the bacterial phosphotransferase system. I. Properties of the purified permease

1983

Jacobson, G.R.; Lee, C.A.; Leonard, J.E.; Saier, M.H.

J. Biol. Chem.

258

10748-10756

692901

18931112

A unique GTP dependent sporulation sensor histidine kinase in Bacillus anthracis

2008

Scaramozzino, F.; White, A.; Perego, M.; Hoch, J.A.

J. Bacteriol.

191

687-692

776951

37015930

Molecular basis for METTL9-mediated N1-histidine methylation

2023

Wang, X.; Xie, H.; Guo, Q.; Cao, D.; Ru, W.; Zhao, S.; Zhu, Z.; Zhang, J.; Pan, W.; Yao, X.; Xu, C.

Cell Discov.

9

38

776953

37398635

Molecular basis for protein histidine N1-specific methylation of the ''His-x-His'' motifs by METTL9

2023

Zhao, W.; Zhou, Y.; Li, C.; Bi, Y.; Wang, K.; Ye, M.; Li, H.

Cell Insight

2

100090

778682

33563959

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

2021

Davydova, E.; Shimazu, T.; Schuhmacher, M.K.; Jakobsson, M.E.; Willemen, H.L.D.M.; Liu, T.; Moen, A.; Ho, A.Y.Y.; Malecki, J.; Schroer, L.; Pinto, R.; Suzuki, T.; Gronsberg, I.A.; Sohtome, Y.; Akakabe, M.; Weirich, S.; Kikuchi, M.; Olsen, J.V.; Dohmae, N.; Umehara, T.; Sodeoka, M.; Siino, V.; McDonough, M.A.; Eijkelkamp, N.; Schofield, C.J.; Jeltsch, A.; Shinkai, Y.; Falnes, P.O.

Nat. Commun.

12

891

Links to other databases for protein-L-histidine

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Show Links (1 entry)