Information on EC - adenosylcobinamide kinase

for references in articles please use BRENDA:EC2.7.1.156
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IUBMB Comments
In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC and EC, CobT (EC, CobC (EC and CobS (EC catalyse reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl). CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole. The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by Cob U. The final step in adenosylcobalamin biosynthesis is the condensation of AdoCbi-GDP with alpha-ribazole, which is catalysed by EC, adenosylcobinamide-GDP ribazoletransferase (CobS), to yield adenosylcobalamin. CobU is a bifunctional enzyme that has both kinase (EC and guanylyltransferase (EC, adenosylcobinamide-phosphate guanylyltransferase) activities. However, both activities are not required at all times. The kinase activity has been proposed to function only when S. typhimurium is assimilating cobinamide whereas the guanylyltransferase activity is required for both assimilation of exogenous cobinamide and for de novo synthesis of adenosylcobalamin .
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
adenosylcobinamide kinase, adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase, AdoCbi kinase/AdoCbi-phosphate guanylyltransferase, ATP/GTP:AdoCbi kinase, bifunctional CobU enzyme, CobP, CobU, CobU AdoCbi kinase, CobU protein, GTP:adenosylcobinamide-phosphate guanylyltransferase, more
RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP [where RTP is either ATP or GTP]
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