Protein Variants | Comment | Organism |
---|---|---|
H45A | site-directed mutagenesis | Salmonella enterica subsp. enterica serovar Typhimurium |
H45A/H46A | site-directed mutagenesis | Salmonella enterica subsp. enterica serovar Typhimurium |
H46A | site-directed mutagenesis | Salmonella enterica subsp. enterica serovar Typhimurium |
H46N | site-directed mutagenesis | Salmonella enterica subsp. enterica serovar Typhimurium |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosylcobinamide-phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
diphosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + adenosylcobinamide | Salmonella enterica subsp. enterica serovar Typhimurium | - |
adenosylcobinamide phosphate + ADP | - |
? | |
ATP + adenosylcobinamide | Salmonella enterica subsp. enterica serovar Typhimurium | late steps of cobalamin biosynthesis, involved in de novo synthesis of vitamin B12, nucleotide loop assembly, enzyme functions only if Salmonella typhimurium is assimilating cobinamide from its environment, CobU becomes less active during the kinase reaction due to the formation of a covalent CobU-AMP complex that holds CobU in an altered conformation | adenosylcobinamide phosphate + ADP | - |
? | |
GTP + adenosylcobinamide | Salmonella enterica subsp. enterica serovar Typhimurium | - |
adenosylcobinamide phosphate + GDP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00000003 | - |
GTP:kinase specific activity, mutant H46A | Salmonella enterica subsp. enterica serovar Typhimurium |
0.00000008 | - |
GTP:kinase specific activity, mutant H46N | Salmonella enterica subsp. enterica serovar Typhimurium |
0.000251 | - |
GTP:kinase specific activity, mutant H45A | Salmonella enterica subsp. enterica serovar Typhimurium |
0.001166 | - |
GTP:kinase specific activity, wild-type | Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5'-deoxyadenosylcobinamide | highest kinase activity, product generation relative to adenosylcobinamide 102% | Salmonella enterica subsp. enterica serovar Typhimurium | 5'-deoxyadenosylcobinamide phosphate + ADP | - |
? | |
ATP + 5'-deoxycytosylcobinamide | about 65% of the activity with AdoCbi | Salmonella enterica subsp. enterica serovar Typhimurium | 5'-deoxycytosylcobinamide phosphate + ADP | - |
? | |
ATP + 5'-deoxyinosylcobinamide | about 55% of the activity with AdoCbi | Salmonella enterica subsp. enterica serovar Typhimurium | 5'-deoxyinosylcobinamide phosphate + ADP | - |
? | |
ATP + adenosylcobinamide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | adenosylcobinamide phosphate + ADP | - |
? | |
ATP + adenosylcobinamide | late steps of cobalamin biosynthesis, involved in de novo synthesis of vitamin B12, nucleotide loop assembly, enzyme functions only if Salmonella typhimurium is assimilating cobinamide from its environment, CobU becomes less active during the kinase reaction due to the formation of a covalent CobU-AMP complex that holds CobU in an altered conformation | Salmonella enterica subsp. enterica serovar Typhimurium | adenosylcobinamide phosphate + ADP | - |
? | |
dATP + adenosylcobinamide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | adenosylcobinamide phosphate + dADP | - |
? | |
dGTP + adenosylcobinamide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | adenosylcobinamide phosphate + dGDP | - |
? | |
GTP + adenosylcobinamide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | adenosylcobinamide phosphate + GDP | - |
? | |
additional information | (CN)2Cbi is no substrate, no product formation with CTP, UTP or dCTP | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
adenosylcobinamide kinase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
CobU | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
CobU AdoCbi kinase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |