Information on EC 2.7.1.140 - inositol-tetrakisphosphate 5-kinase

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EC Tree 2 Transferases 2.7 Transferring phosphorus-containing groups 2.7.1 Phosphotransferases with an alcohol group as acceptor 2.7.1.140 inositol-tetrakisphosphate 5-kinase

IUBMB Comments

The enzyme from plants and yeast can also use Ins(1,2,3,4,6)P₅ as a substrate .

The enzyme appears in viruses and cellular organisms

Reaction Schemes

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ATP

1D-myo-inositol 1,3,4,6-tetrakisphosphate

ADP

1D-myo-inositol 1,3,4,5,6-pentakisphosphate

Synonyms
ins(1,3,4,6)p4 5-kinase, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

1D-myo-inositol-tetrakisphosphate 5-kinase

Ins(1,3,4,6)P4 5-kinase

Homo sapiens

659473

kinase, inositol 1,3,4,6-tetrakisphosphate 5-(phosphorylating)

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

phospho group transfer

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Go to Pathway Search

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PATHWAY SOURCE

PATHWAYS

KEGG

Inositol phosphate metabolism

MetaCyc

1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), 1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium), 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3), D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis, D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis

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SYSTEMATIC NAME

IUBMB Comments

ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase

The enzyme from plants and yeast can also use Ins(1,2,3,4,6)P5 as a substrate [2].

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CAS REGISTRY NUMBER

COMMENTARY

123940-40-9

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

ATP + myo-inositol 1,3,4,5-tetrakisphosphate

ADP + myo-inositol-1,3,4,5,6-pentakisphosphate

Homo sapiens

640974

Substrates: approx. 2% of activity with 1,3,4,6-tetrakisphosphate
Products: -

ATP + myo-inositol 1,3,4,6-tetrakisphosphate

ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

6 entries

ATP + myo-inositol 1,4,5-trisphosphate

ADP + myo-inositol-1,3,4,5-tetrakisphosphate

Homo sapiens

640974

Substrates: approx. 50% of activity with 1D-myo-inositol 1,3,4,6-tetrakisphosphate, no activity with 1D-myo-inositol 1,3,4-trisphosphate
Products: -

ATP + myo-inositol 1,3,4,6-tetrakisphosphate

ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

Bos taurus

640815

Substrates: -
Products: -

ATP + myo-inositol 1,3,4,6-tetrakisphosphate

ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

Homo sapiens

640974

Substrates: -
Products: -

ATP + myo-inositol 1,3,4,6-tetrakisphosphate

ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

Rattus norvegicus

640971, 640973

Substrates: -
Products: -

ATP + myo-inositol 1,3,4,6-tetrakisphosphate

ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

Rattus norvegicus

640971

Substrates: involved in synthesis of higher phosphorylated inositol phosphates
Products: -

ATP + myo-inositol 1,3,4,6-tetrakisphosphate

ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

Rattus norvegicus Sprague-Dawley

640971

Substrates: -
Products: -

ATP + myo-inositol 1,3,4,6-tetrakisphosphate

ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

Rattus norvegicus Sprague-Dawley

640971

Substrates: involved in synthesis of higher phosphorylated inositol phosphates
Products: -

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ATP + myo-inositol 1,3,4,6-tetrakisphosphate

ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

3 entries

ATP + myo-inositol 1,3,4,6-tetrakisphosphate

ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

Homo sapiens

640974

Substrates: -
Products: -

ATP + myo-inositol 1,3,4,6-tetrakisphosphate

ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

Rattus norvegicus

640971

Substrates: involved in synthesis of higher phosphorylated inositol phosphates
Products: -

ATP + myo-inositol 1,3,4,6-tetrakisphosphate

ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

Rattus norvegicus Sprague-Dawley

640971

Substrates: involved in synthesis of higher phosphorylated inositol phosphates
Products: -

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00013

myo-inositol-1,3,4,5-tetrakisphosphate

Homo sapiens

pH 7.2, 37°C

640974

0.0003

myo-inositol-1,3,4,6-tetrakisphosphate

Homo sapiens

pH 7.2, 37°C

640974

0.00011

myo-inositol-1,4,5-trisphosphate

Homo sapiens

pH 7.2, 37°C

640974

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

7.2

Rattus norvegicus

assay at

640971

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

brenda

Rattus norvegicus Sprague-Dawley

Sprague-Dawley strain

640971

brenda

Homo sapiens

expression in HEK-293 cells

brenda

human EST

brenda

brenda

Sprague-Dawley strain

640971

brenda

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks

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SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

brain

Rattus norvegicus

640973

brenda

cell suspension culture

brenda

permeabilized

brenda

brenda

Rattus norvegicus Sprague-Dawley

brenda

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks

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LOCALIZATION

ORGANISM

UNIPROT

COMMENTARY

GeneOntology No.

LITERATURE

SOURCE

brenda

Highest Expressing Human Cell Lines

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Gene Links

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PDB

SCOP

CATH

UNIPROT

ORGANISM

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Homo sapiens

gene silencing of enzyme results in decreased inositol pentakisphosphate and inositol hexakisphosphate levels

659473

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

recombinant His-tagged enzyme, cobalt-affinity column

Homo sapiens

640974

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expression in Escherichia coli

Homo sapiens

640974

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

synthesis

Homo sapiens

overexpression of enzyme does not increase the level of inositolpentakisphosphate, gene silencing of enzyme results in decreased inositol pentakisphosphate and inositol hexakisphosphate levels

659473

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

640815

Balla, T.; Hunyadi, L.; Baukal, A.J.; Catt, K.J.

Structures and metabolism of inositol tetrakisphosphates and inositol pentakisphosphate in bovine adrenal glomerulosa cells

J. Biol. Chem.

264

9386-9390

1989

Bos taurus

2722840

brenda

640971

Shears, S.B.

The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase

J. Biol. Chem.

264

19879-19886

1989

Rattus norvegicus, Rattus norvegicus Sprague-Dawley

2584198

brenda

640973

Stephens, L.R.; Hawkins, P.T.; Barker, C.J.; Downes, C.P.

Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation

Biochem. J.

253

721-733

1988

Rattus norvegicus

2845930

brenda

640974

Chang, S.C.; Miller, A.L.; Feng, Y.; Wente, S.R.; Majerus, P.W.

The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase

J. Biol. Chem.

277

43836-43843

2002

Homo sapiens

12223481

brenda

659473

Verbsky, J.W.; Chang, S.C.; Wilson, M.P.; Mochizuki, Y.; Majerus, P.W.

The pathway for the production of inositol hexakisphosphate in human cells

J. Biol. Chem.

280

1911-1920

2005

Homo sapiens

15531582

brenda

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EXTERNAL LINKS (specific for EC-Number 2.7.1.140)

ExplorEnz (official portal for IUBMB Enzyme Nomenclature)

Expasy Enzyme Nomenclature Database

KEGG

SABIO-RK

NCBI: PubMed, Protein, Nucleotide, Structure, Gene, OMIM

Enzyme Nomenclature (alternative site)

UniProt

PDB

PROSITE Database of protein families and domains

InterPro (database of protein families, domains and functional sites)

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