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Ligand myo-inositol 1,3,4,5,6-pentakisphosphate

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

KEGG

Inositol phosphate metabolism, Phosphatidylinositol signaling system

MetaCyc

1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3), 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), 1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza), 1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium), 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3), D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis, D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis, inositol diphosphates biosynthesis more

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (15 results)

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Show Natural Substrate (15 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.151

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphosphoinositol tetrakisphosphate

662391

-

2.7.1.158

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP

676634

2xan, 3D-view

2.7.1.158

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP

676634

2xao, 3D-view

2.7.1.158

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP

676634

3udt, 3D-view

2.7.1.158

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP

676634

5mw8, 3D-view

2.7.1.158

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP

676634

5mwl, 3D-view

2.7.1.158

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP

676634

6fl3, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate

737644, 738042, 738742, 662336, 661020, 738602, 739381, 737654, 738589, 739275, 739312, 760534, 761678, 762144, 761460, 762323, 760240, 761238, 760326, 761763, 662307, 663251, 662093, 393221, 686761

2xan, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate

737644, 738042, 738742, 662336, 661020, 738602, 739381, 737654, 738589, 739275, 739312, 760534, 761678, 762144, 761460, 762323, 760240, 761238, 760326, 761763, 662307, 663251, 662093, 393221, 686761

2xao, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate

737644, 738042, 738742, 662336, 661020, 738602, 739381, 737654, 738589, 739275, 739312, 760534, 761678, 762144, 761460, 762323, 760240, 761238, 760326, 761763, 662307, 663251, 662093, 393221, 686761

3udt, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate

737644, 738042, 738742, 662336, 661020, 738602, 739381, 737654, 738589, 739275, 739312, 760534, 761678, 762144, 761460, 762323, 760240, 761238, 760326, 761763, 662307, 663251, 662093, 393221, 686761

5mw8, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate

737644, 738042, 738742, 662336, 661020, 738602, 739381, 737654, 738589, 739275, 739312, 760534, 761678, 762144, 761460, 762323, 760240, 761238, 760326, 761763, 662307, 663251, 662093, 393221, 686761

5mwl, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate

737644, 738042, 738742, 662336, 661020, 738602, 739381, 737654, 738589, 739275, 739312, 760534, 761678, 762144, 761460, 762323, 760240, 761238, 760326, 761763, 662307, 663251, 662093, 393221, 686761

6fl3, 3D-view

2.7.1.158

12 entries

2.7.1.159

1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP = 1D-myo-inositol-3,4,5,6-tetrakisphosphate + ATP

690054

-

3.1.3.62

inositol 1,3,4,5,6-pentakisphosphate + H2O = inositol 1,4,5,6-tetrakisphosphate + phosphate

646432

-

In Vivo Product in Enzyme-catalyzed Reactions (16 results)

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Show Natural Product (16 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.134

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0, 640813

-

2.7.1.140

ATP + myo-inositol 1,3,4,6-tetrakisphosphate = ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

640974, 640971

-

2.7.1.151

2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate = 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

ATP + inositol 1,4,5,6-tetrakisphosphate = ADP + inositol (1,3,4,5,6)-pentakisphosphate

0

-

2.7.1.151

inositol (1,4,5,6)-tetrakisphosphate + ATP = inositol (1,3,4,5,6)-pentakisphosphate + ADP

0

-

2.7.1.159

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.159

1D-myo-inositol-1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP

0

-

2.7.1.159

1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP

0

-

2.7.1.151

9 entries

2.7.1.159

3 entries

3.1.3.62

inositol hexakisphosphate + H2O = inositol pentakisphosphate + phosphate

646432

-

3.6.1.52

diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate

0

-

Substrate in Enzyme-catalyzed Reactions (26 results)

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Show Substrate (26 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.151

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphosphoinositol tetrakisphosphate

662391

-

2.7.1.151

inositol pentakisphosphate + ATP = diphosphoinositol tetrakisphosphate + ADP

393223

-

2.7.1.151

inositol pentakisphosphate + ATP = inositol hexakisphosphate + ADP

393221, 393219

-

2.7.1.158

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP

676634

2xan, 3D-view

2.7.1.158

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP

676634

2xao, 3D-view

2.7.1.158

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP

676634

3udt, 3D-view

2.7.1.158

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP

676634

5mw8, 3D-view

2.7.1.158

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP

676634

5mwl, 3D-view

2.7.1.158

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP

676634

6fl3, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate

662117, 737644, 738042, 738742, 662336, 662106, 662093, 661020, 738602, 660942, 739381, 737654, 738589, 739275, 739312, 760534, 761678, 762144, 761460, 762323, 760240, 761238, 760326, 761763, 662307, 663251, 393221, 686761

2xan, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate

662117, 737644, 738042, 738742, 662336, 662106, 662093, 661020, 738602, 660942, 739381, 737654, 738589, 739275, 739312, 760534, 761678, 762144, 761460, 762323, 760240, 761238, 760326, 761763, 662307, 663251, 393221, 686761

2xao, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate

662117, 737644, 738042, 738742, 662336, 662106, 662093, 661020, 738602, 660942, 739381, 737654, 738589, 739275, 739312, 760534, 761678, 762144, 761460, 762323, 760240, 761238, 760326, 761763, 662307, 663251, 393221, 686761

3udt, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate

662117, 737644, 738042, 738742, 662336, 662106, 662093, 661020, 738602, 660942, 739381, 737654, 738589, 739275, 739312, 760534, 761678, 762144, 761460, 762323, 760240, 761238, 760326, 761763, 662307, 663251, 393221, 686761

5mw8, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate

662117, 737644, 738042, 738742, 662336, 662106, 662093, 661020, 738602, 660942, 739381, 737654, 738589, 739275, 739312, 760534, 761678, 762144, 761460, 762323, 760240, 761238, 760326, 761763, 662307, 663251, 393221, 686761

5mwl, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate

662117, 737644, 738042, 738742, 662336, 662106, 662093, 661020, 738602, 660942, 739381, 737654, 738589, 739275, 739312, 760534, 761678, 762144, 761460, 762323, 760240, 761238, 760326, 761763, 662307, 663251, 393221, 686761

6fl3, 3D-view

2.7.1.158

ATP + myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + myo-inositol hexakisphosphate

676634

2xan, 3D-view

2.7.1.158

ATP + myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + myo-inositol hexakisphosphate

676634

2xao, 3D-view

2.7.1.158

ATP + myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + myo-inositol hexakisphosphate

676634

3udt, 3D-view

2.7.1.158

ATP + myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + myo-inositol hexakisphosphate

676634

5mw8, 3D-view

2.7.1.158

ATP + myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + myo-inositol hexakisphosphate

676634

5mwl, 3D-view

2.7.1.158

ATP + myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + myo-inositol hexakisphosphate

676634

6fl3, 3D-view

2.7.1.151

3 entries

2.7.1.158

18 entries

2.7.1.159

1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP = 1D-myo-inositol-3,4,5,6-tetrakisphosphate + ATP

690054

-

2.7.4.21

ATP + 1D-myo-inositol-1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate

642554

4o4e, 3D-view

3.1.3.26

inositol pentakisphosphate + H2O = ?

94796, 94803, 94800

-

3.1.3.26

myo-inositol-1,3,4,5,6 pentakisphosphate + H2O = ?

94801

-

3.1.3.26

2 entries

3.1.3.62

inositol 1,3,4,5,6-pentakisphosphate + H2O = inositol 1,4,5,6-tetrakisphosphate + phosphate

646436, 694894, 646432, 646437

-

Product in Enzyme-catalyzed Reactions (44 results)

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Show Product (44 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.134

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0, 640813, 640815, 640819, 640820, 640814, 640821, 640818

-

2.7.1.140

ATP + myo-inositol 1,3,4,6-tetrakisphosphate = ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

640974, 640971, 640973, 640815

-

2.7.1.140

ATP + myo-inositol 1,3,4,5-tetrakisphosphate = ADP + myo-inositol-1,3,4,5,6-pentakisphosphate

640974

-

2.7.1.151

2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

3 ATP + 2 1D-myo-inositol 1,4,5-trisphosphate = 3 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

2 ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = 2 ADP + 2 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.151

ATP + inositol 1,3,4,5-tetrakisphosphate = ADP + inositol (1,3,4,5,6)-pentakisphosphate

0

-

2.7.1.151

ATP + inositol 1,4,5,6-tetrakisphosphate = ADP + inositol (1,3,4,5,6)-pentakisphosphate

0

-

2.7.1.151

inositol (1,3,4,5)-tetrakisphosphate + ATP = inositol (1,3,4,5,6)-pentakisphosphate + ADP

393222

-

2.7.1.151

inositol (1,3,4,6)-tetrakisphosphate + ATP = ADP + inositol (1,3,4,5,6)-pentakisphosphate

0

-

2.7.1.151

inositol (1,4,5,6)-tetrakisphosphate + ATP = inositol (1,3,4,5,6)-pentakisphosphate + ADP

393222, 0

-

2.7.1.151

inositol (3,4,5,6)-tetrakisphosphate + ATP = inositol (1,3,4,5,6)-pentakisphosphate + ADP

0

-

2.7.1.151

inositol (1,3,4,5)-tetrakisphosphate + ATP = inositol pentakisphosphate + ADP

393223

-

2.7.1.151

inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP

393219

-

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

2xan, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

2xao, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

3udt, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

5mw8, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

5mwl, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

6fl3, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

2xan, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

2xao, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

3udt, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

5mw8, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

5mwl, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

6fl3, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

2xan, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

2xao, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

3udt, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

5mw8, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

5mwl, 3D-view

2.7.1.158

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

6fl3, 3D-view

2.7.1.159

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

0

-

2.7.1.159

1D-myo-inositol-1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP

0

-

2.7.1.159

1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP

0

-

2.7.1.159

ATP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate = ADP + 1D-myo-inositol-1,3,4,5,6-pentakisphosphate

0

-

2.7.1.140

2 entries

2.7.1.151

15 entries

2.7.1.158

18 entries

2.7.1.159

4 entries

3.1.3.26

myo-inositol hexakisphosphate + H2O = L-myo-inositol 1,2,3,4,5-pentakisphosphate + myo-inositol 1,2,3,4,6-pentakisphosphate + myo-inositol 1,3,4,5,6-pentakisphosphate + myo-inositol 2-phosphate + D-myo-inositol 1,2-bisphosphate + L-myo-inositol 1,2-bis phosphate + L-myo-inositol 1,2,3,4-tetrakisphosphate + phosphate

94783

-

3.1.3.56

5-diphosphoinositol 1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4,5,6-pentakisphosphate + phosphate

0

-

3.1.3.62

inositol hexakisphosphate + H2O = inositol pentakisphosphate + phosphate

0, 646432

-

3.6.1.52

diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate

0

-

Activator in Enzyme-catalyzed Reactions (1 result)

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Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.4.24.56

activates, maximal 83.3fold activation

755263

-

Inhibitor in Enzyme-catalyzed Reactions (8 results)

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Show Inhibitors (8 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.134

competitive inhibition

640817

-

2.7.4.21

IC50 for inositol hexakisphosphate kinase activity is 0.022 mM, IC50 for ATP synthase activity is 0.0128 mM

642551

4o4e, 3D-view

3.1.3.25

-

114220

-

3.1.3.56

-

646384

-

3.1.3.62

-

646429, 646435

-

3.1.3.62

0.001 mM, 50% inhibition; competitive; strong, kinetics

646381

-

3.1.3.62

competitive; strong, kinetics; turkey hemoglobin reverses

646432

-

3.1.3.62

strong, kinetics

646384

-

3.1.3.62

4 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (97 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (97 entries)

EC NUMBER

ENZYME 3D STRUCTURE

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

2xan, 3D-view

2.7.1.158

2xao, 3D-view

2.7.1.158

3udt, 3D-view

2.7.1.158

5mw8, 3D-view

2.7.1.158

5mwl, 3D-view

2.7.1.158

6fl3, 3D-view

2.7.1.158

96 entries

2.7.4.21

4o4e, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (10 results)

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Show Turnover Number (10 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.7.1.158

0.246

-

mutant enzyme N238A, at pH 7.5 and 25°C

738589

2.7.1.158

0.265

-

mutant enzyme N239A, at pH 7.5 and 25°C

738589

2.7.1.158

0.279

-

mutant enzyme K200A, at pH 7.5 and 25°C

738589

2.7.1.158

0.367

-

mutant enzyme R192A, at pH 7.5 and 25°C

738589

2.7.1.158

0.453

-

mutant enzyme R45A, at pH 7.5 and 25°C

738589

2.7.1.158

0.569

-

mutant enzyme H196A, at pH 7.5 and 25°C

738589

2.7.1.158

0.645

-

mutant enzyme R415A, at pH 7.5 and 25°C

738589

2.7.1.158

0.694

-

mutant enzyme Y419A, at pH 7.5 and 25°C

738589

2.7.1.158

0.734

-

wild type enzyme, at pH 7.5 and 25°C

738602, 738589

2.7.1.158

0.736

-

mutant enzyme E82C/S142C, at pH 7.5 and 25°C

738602

2.7.1.158

10 entries

K_M Value (22 results)

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Show KM Value (22 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.158

0.0004

-

-

662117

2.7.1.158

0.000644

-

-

662106

2.7.1.158

0.0023

-

-

662093

2.7.1.158

0.022

-

30°C, pH 7.5

661020

2.7.1.158

0.022

-

at 0.4 mM ATP

661020

2.7.1.158

0.03372

-

mutant enzyme N238A, at pH 7.5 and 25°C

738589

2.7.1.158

0.03979

-

mutant enzyme K200A, at pH 7.5 and 25°C

738589

2.7.1.158

0.04348

-

mutant enzyme H196A, at pH 7.5 and 25°C

738589

2.7.1.158

0.04453

-

mutant enzyme E82C/S142C, at pH 7.5 and 25°C

738602

2.7.1.158

0.0548

-

mutant enzyme R45A, at pH 7.5 and 25°C

738589

2.7.1.158

0.05935

-

mutant enzyme R192A, at pH 7.5 and 25°C

738589

2.7.1.158

0.06227

-

mutant enzyme R415A, at pH 7.5 and 25°C

738589

2.7.1.158

0.0628

-

-

662106

2.7.1.158

0.06305

-

wild type enzyme, at pH 7.5 and 25°C

738602, 738589

2.7.1.158

0.07686

-

mutant enzyme Y419A, at pH 7.5 and 25°C

738589

2.7.1.158

0.0833

-

mutant enzyme N239A, at pH 7.5 and 25°C

738589

2.7.1.158

0.119

-

-

676634

2.7.1.158

0.119

-

400 microM of substrate ATP is used

676634

2.7.1.158

0.119

-

-

676634

2.7.1.158

0.176

-

at 0.0004 mM ATP

661020

2.7.1.158

20 entries

2.7.4.21

0.0055

-

pH 7.0, 37°C

642554

3.1.3.62

0.00004

-

pH 7.4, 37°C

646432

K_i Value (5 results)

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Show KI Value (5 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.134

0.015

-

pH 7.2, 37°C

640817

3.1.3.56

0.02

-

with inositol 1,4,5-trisphosphate as substrate

646384

3.1.3.56

0.035

-

with inositol 1,3,4,5-tetrakisphosphate as substrate

646384

3.1.3.62

0.000025

-

pH 7.4, 37°C

646432

3.1.3.62

0.00006

-

pH 7.4, 37°C

646384

3.1.3.56

2 entries

3.1.3.62

2 entries

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

2.7.4.21

0.0128

-

IC50 for inositol hexakisphosphate kinase activity is 0.022 mM, IC50 for ATP synthase activity is 0.0128 mM

642551

References & Links

Literature References (62)

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Show Reference (62 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

94783

4349266

The phytases. II. Properties of phytase fractions F1 and F2 from wheat bran and the myo-inositol phosphates produced by fraction F2

1973

Lim, P.E.; Tate, M.E.

Biochim. Biophys. Acta

302

316-328

94796

-

Isolation, purification and characterization of phytase from germinating mung beans

1972

Mandal, N.C.; Burman, S.; Biswas, B.B.

Phytochemistry

11

495-502

94800

8240238

Purification and characterization of a phytase (myo-inositol-hexakisphosphate phosphohydrolase) accumulated in maize (Zea mays) seedlings during germination

1993

Laboure, A.M.; Gagnon, J.; Lescure, A.M.

Biochem. J.

295

413-419

94801

-

Localization of constitutive phytases in lily pollen and properties of the pH 8 form

1988

Baldi, B.G.; Scott, J.J.; Everard, J.D.; Loewus, F.A.

Plant Sci.

56

137-147

94803

1654110

Purification and characterization of phytase from rat intestinal mucosa

1991

Yang, W.J.; Matsuda, Y.; Sano, S.I.; Masutani, H.; Nakagawa, H.

Biochim. Biophys. Acta

1075

75-82

114220

6272635

Studies on avian erythrocyte metabolism: purification and properties of myo-inositol 1-phosphatase from chick erythrocytes

1981

Roth, S.C.; Harkness, D.R.; Isaacks, R.E.

Arch. Biochem. Biophys.

210

465-473

393219

-

Purification of phosphoinositol kinase from suspension-cultured cells of rice (Oryza sativa L.)

1995

Yotsushima, K.; Mitsui, T.; Hayakawa, T.

Biosci. Biotechnol. Biochem.

59

1953-1955

393221

10390371

A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export

1999

York, J.D.; Odom, A.R.; Murphy, R.; Ives, E.B.; Wente, S.R.

Science

285

96-100

393222

10713273

Corrigendum to: activation of interstitial collagenase, MMP-1, by staphylococcus aureus cells having surface-bound plasmin: a novel role of plasminogen receptors of bacteria

2000

Saiardi, A.; Caffrey, J.J.; Snyder, S.H.; Shears, S.B.

FEBS Lett.

469

213

393223

11226235

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate

2001

Saiardi, A.; Nagata, E.; Luo, H.R.; Sawa, A.; Luo, X.; Snowman, A.M.; Snyder, S.H.

Proc. Natl. Acad. Sci. USA

98

2306-2311

640813

8308002

Inositol 1,4,5,6-tetrakisphosphate is phosphorylated in rat liver by a 3-kinase that is distinct from inositol 1,4,5-trisphosphate 3-kinase

1994

Craxton, A.; Erneux, C.; Shears, S.B.

J. Biol. Chem.

269

4337-4342

640814

2829850

L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase

1988

Stephens, L.R.; Hawkins, P.T.; Morris, A.J.; Downes, C.P.

J. Biol. Chem.

249

283-292

640815

2722840

Structures and metabolism of inositol tetrakisphosphates and inositol pentakisphosphate in bovine adrenal glomerulosa cells

1989

Balla, T.; Hunyadi, L.; Baukal, A.J.; Catt, K.J.

J. Biol. Chem.

264

9386-9390

640817

8999935

Properties of the inositol 3,4,5,6-tetrakisphosphate 1-kinase purified from rat liver. Regulation of enzyme activity by inositol 1,3,4-trisphosphate

1997

Tan, Z.; Bruzik, K.S.; Shears, S.B.

J. Biol. Chem.

272

2285-2290

640818

-

Identification of inositol 1,3,4-trisphosphate 5-kinase and inositol 1,3,4,5-tetrakisphosphate 6-kinase in immature soybean seeds

1998

Phillippy, B.Q.

Plant Physiol.

116

291-297

640819

10759517

Metabolic relations of inositol 3,4,5,6-tetrakisphosphate revealed by cell permeabilization. Identification of inositol 3,4,5, 6-tetrakisphosphate 1-kinase and inositol 3,4,5,6-tetrakisphosphate phosphatase activities in mesophyll cells

2000

Brearley, C.A.; Hanke, D.E.

Plant Physiol.

122

1209-1216

640820

-

Multitasking in signal transduction by a promiscuous human ins(3,4,5,6)P4 1-kinase/ins(1,3,4)P3 5/6-kinase

2000

Yang, X.; Shears, B.S.

Biochem. J.

351

551-555

640821

11909533

Regulation of ins(3,4,5,6)P4 signaling by a reversible kinase/phosphatase

2002

Ho, M.W.Y.; Yang, X.; Carew, M.A.; Zhang, T.; Hua, L.; Kwon, Y-U.; Chung, S-K.; Adelt, S.; Vogel, G.; Riley, a.M.; Potter, B.V.L.; Shears, S.B.

Curr. Biol.

12

477-482

640971

2584198

The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase

1989

Shears, S.B.

J. Biol. Chem.

264

19879-19886

640973

2845930

Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation

1988

Stephens, L.R.; Hawkins, P.T.; Barker, C.J.; Downes, C.P.

Biochem. J.

253

721-733

640974

12223481

The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase

2002

Chang, S.C.; Miller, A.L.; Feng, Y.; Wente, S.R.; Majerus, P.W.

J. Biol. Chem.

277

43836-43843

642551

8633060

Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donor

1996

Voglmaier, S.M.; Bembenek, M.E.; Kaplin, A.I.; Dorman, G.; Olszewski, J.D.; Prestwich, G.D.; Snyder, S.H.

Proc. Natl. Acad. Sci. USA

93

4305-4310

642554

11502751

Identification and characterization of a novel inositol hexakisphosphate kinase

2001

Saiardi, A.; Nagata, E.; Luo, H.R.; Snowman, A.M.; Snyder, S.H.

J. Biol. Chem.

276

39179-39185

646381

2161845

Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate inhibit inositol-1,3,4,5-tetrakisphosphate 3-phosphatase in rat parotid glands

1990

Hughes, P.J.; Shears, S.B.

J. Biol. Chem.

265

9869-9875

646384

1652939

Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate are inhibitors of the soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase and the inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase from pig brain

1991

Höer, A.; Oberdisse, E.

Biochem. J.

278

219-224

646429

2173549

Properties of a soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase from porcine brain

1990

Höer, A.; Höer, D.; Oberdisse, E.

Biochem. J.

270

715-719

646432

1653239

Purification of an inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity from rat liver and the evaluation of its substrate specificity

1991

Nogimori, K.; Hughes, P.J.; Glennon, M.C.; Hodgson, M.E.; Putney, J.W.; Shears, S.B.

J. Biol. Chem.

266

16499-16506

646435

7832765

Comparison of the activities of a multiple inositol polyphosphate phosphatase obtained from several sources: a search for heterogeneity in this enzyme

1995

Craxton, A.; Ali, N.; Shears, S.B.

Biochem. J.

305

491-498

646436

14567985

The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase

2003

Hidaka, K.; Kanematsu, T.; Caffrey, J.J.; Takeuchi, H.; Shears, S.B.; Hirata, M.

Exp. Cell Res.

290

254-264

646437

12963730

Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca2+ concentration

2003

Yu, J.; Leibiger, B.; Yang, S.N.; Caffery, J.J.; Shears, S.B.; Leibiger, I.B.; Barker, C.J.; Berggren, P.O.

J. Biol. Chem.

278

46210-46218

660942

-

Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation

1998

Ongusaga, P.P.; Hughes, P.J.; Davey, J.; Michell, R.H.

Biochem. J.

335

671-679

661020

16223361

Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1)

2006

Sweetman, D.; Johnson, S.; Caddick, S.E.; Hanke, D.E.; Brearley, C.A.

Biochem. J.

394

95-103

662093

7961779

Purification and some properties of inositol 1,3,4,5,6-pentakis phosphate 2-kinase from immature soybean seeds

1994

Phillippy, B.Q.; Ullah, A.H.J.; Ehrlich, K.C.

J. Biol. Chem.

269

28393-28399

662106

10960485

Biochemical and functional characterization of inositol 1,3,4,5,6-pentakisphosphate 2-kinases

2000

Ives, E.B.; Nichols, J.; Wente, S.R.; York, J.D.

J. Biol. Chem.

275

36575-36583

662117

12084730

The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase

2002

Verbsky, J.W.; Wilson, M.P.; Kisseleva, M.V.; Majerus, P.W.; Wente, S.R.

J. Biol. Chem.

277

31857-31862

662307

15459192

Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway

2004

Miller, A.L.; Suntharalingam, N.; et al.

J. Biol. Chem.

279

51022-51032

662336

15528195

A role for rat inositol polyphosphate kinases rIPK2 and rIPK1 in inositol pentakisphosphate and inositol hexakisphosphate production in rat-1 cells

2005

Fujii, M.; York, J.D.

J. Biol. Chem.

280

1156-1164

662391

15944147

Molecular definition of a novel inositol polyphosphate metabolic pathway initiated by inositol 1,4,5-trisphosphate 3-kinase activity in Saccharomyces cerevisiae

2005

Seeds, A.M.; Bastidas, R.J.; York, J.D.

J. Biol. Chem.

280

27654-27661

663251

15939868

Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression

2005

Verbsky, J.; Lavine, K.; Majerus, P.W.

Proc. Natl. Acad. Sci. USA

102

8448-8453

676634

17535825

Inositol 1,3,4,5,6-pentakisphosphate 2-kinase from maize: molecular and biochemical characterization

2007

Sun, Y.; Thompson, M.; Lin, G.; Butler, H.; Gao, Z.; Thornburgh, S.; Yau, K.; Smith, D.A.; Shukla, V.K.

Plant Physiol.

144

1278-1291

686761

18442482

A Solanum tuberosum inositol phosphate kinase (StITPK1) displaying inositol phosphate-inositol phosphate and inositol phosphate-ADP phosphotransferase activities

2008

Caddick, S.E.; Harrison, C.J.; Stavridou, I.; Mitchell, J.L.; Hemmings, A.M.; Brearley, C.A.

FEBS Lett.

582

1731-1737

690054

18272466

Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels

2008

Saiardi, A.; Cockcroft, S.

Sci. Signal.

1

1-3

694894

18413611

Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport-Luebering glycolytic shunt

2008

Cho, J.; King, J.S.; Qian, X.; Harwood, A.J.; Shears, S.B.

Proc. Natl. Acad. Sci. USA

105

5998-6003

737644

24865181

Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio

2014

Wundenberg, T.; Grabinski, N.; Lin, H.; Mayr, G.W.

Biochem. J.

462

173-184

737654

27474409

Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport

2016

Chanduri, M.; Rai, A.; Malla, A.B.; Wu, M.; Fiedler, D.; Mallik, R.; Bhandari, R.

Biochem. J.

473

3031-3047

738042

24768307

Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery

2014

Wang, H.; Godage, H.Y.; Riley, A.M.; Weaver, J.D.; Shears, S.B.; Potter, B.V.

Chem. Biol.

21

689-699

738589

23884422

Roles of phosphate recognition in inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) substrate binding and activation

2013

Gosein, V.; Miller, G.J.

J. Biol. Chem.

288

26908-26913

738602

24165122

Conformational stability of inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) dictates its substrate selectivity

2013

Gosein, V.; Miller, G.J.

J. Biol. Chem.

288

36788-36795

738742

-

A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA

2013

Brehm, M.; Wundenberg, T.; Williams, J.; Mayr, G.; Shears, S.

J. Cell Sci.

126

437-444

739275

26264234

An Arabidopsis mutant of inositol pentakisphosphate 2-kinase AtIPK1 displays reduced arsenate tolerance

2016

Sun, Y.Y.; Xu, W.Z.; Wu, L.; Wang, R.Z.; He, Z.Y.; Ma, M.

Plant Cell Environ.

39

416-426

739312

25155524

Arabidopsis inositol pentakisphosphate 2-kinase, AtIPK1, is required for growth and modulates phosphate homeostasis at the transcriptional level

2014

Kuo, H.F.; Chang, T.Y.; Chiang, S.F.; Wang, W.D.; Charng, Y.Y.; Chiou, T.J.

Plant J.

80

503-515

739381

24463774

Molecular and biochemical identification of inositol 1,3,4,5,6-pentakisphosphate 2-kinase encoding mRNA variants in castor bean (Ricinus communis L.) seeds

2014

Yu, J.; Saiardi, A.; Greenwood, J.S.; Bewley, J.D.

Planta

239

965-977

755263

28325868

Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes

2017

Song, E.S.; Jang, H.; Guo, H.F.; Juliano, M.A.; Juliano, L.; Morris, A.J.; Galperin, E.; Rodgers, D.W.; Hersh, L.B.

Proc. Natl. Acad. Sci. USA

114

E2826-E2835

760240

32523862

Expression profiling and in silico homology modeling of inositol pentakisphosphate 2-kinase, a potential candidate gene for low phytate trait in soybean

2020

Basak, N.; Krishnan, V.; Pandey, V.; Punjabi, M.; Hada, A.; Marathe, A.; Jolly, M.; Palaka, B.K.; Ampasala, D.R.; Sachdev, A.

3 Biotech

10

268

760326

30132343

Urine inositol pentakisphosphate 2-kinase and changes in kidney structure in early diabetic kidney disease in type 1 diabetes

2018

Looker, H.C.; Merchant, M.L.; Rane, M.J.; Nelson, R.G.; Kimmel, P.L.; Rovin, B.H.; Klein, J.B.; Mauer, M.; Mauer, M.

Am. J. Physiol. Renal Physiol.

315

F1484-F1492

760534

32706850

An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels

2020

Whitfield, H.; White, G.; Sprigg, C.; Riley, A.M.; Potter, B.V.L.; Hemmings, A.M.; Brearley, C.A.

Biochem. J.

477

2621-2638

761238

-

Molecular characterization of inositol pentakisphosphate 2-kinase (GmlPk1) from soybean and its expression pattern in the developing seeds

2017

Basak, N.; Krishnan, V.; Pandey, V.; Punjabi, M.; Hada, A.; Marathe, A.; Jolly, M.; Sachdev, A.

Indian J. Genet. Plant Breed.

77

371-378

761460

28450399

The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function

2017

Franco-Echevarria, E.; Sanz-Aparicio, J.; Brearley, C.A.; Gonzalez-Rubio, J.M.; Gonzalez, B.

J. Biol. Chem.

292

10534-10548

761678

30160967

A fluorescent probe identifies active site ligands of inositol pentakisphosphate 2-kinase

2018

Whitfield, H.; Gilmartin, M.; Baker, K.; Riley, A.M.; Godage, H.Y.; Potter, B.V.L.; Hemmings, A.M.; Brearley, C.A.

J. Med. Chem.

61

8838-8846

761763

28919350

Crystal structure of inositol 1,3,4,5,6-pentakisphosphate 2-kinase from Cryptococcus neoformans

2017

Oh, J.; Lee, D.G.; Bahn, Y.S.; Rhee, S.

J. Struct. Biol.

200

118-123

762144

29779236

Arabidopsis inositol phosphate kinases IPK1 and ITPK1 constitute a metabolic pathway in maintaining phosphate homeostasis

2018

Kuo, H.; Hsu, Y.; Lin, W.; Chen, K.; Munnik, T.; Brearley, C.; Chiou, T.

Plant J.

95

613-630

762323

28429156

Crystallization and preliminary X-ray diffraction analysis of a mammal inositol 1,3,4,5,6-pentakisphosphate 2-kinase

2017

Franco-Echevarria, E.; Sanz-Aparicio, J.; Troffer-Charlier, N.; Poterszman, A.; Gonzalez, B.

Protein J.

36

240-248

Links to other databases for myo-inositol 1,3,4,5,6-pentakisphosphate

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