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Ligand myo-inositol 1,3,4,6-tetrakisphosphate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Natural Substrate (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.140

ATP + myo-inositol 1,3,4,6-tetrakisphosphate = ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

640974, 640971

-

2.7.1.151

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

640974, 660926, 686905

-

2.7.1.151

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

686905

-

2.7.1.151

2 entries

2.7.1.159

1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP

690054

-

In Vivo Product in Enzyme-catalyzed Reactions (8 results)

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Show Natural Product (8 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.159

1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP

0

-

2.7.1.159

ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

0

-

2.7.1.159

1D-myo-inositol-1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP

0

-

2.7.1.159

1D-myo-inositol-1,3,4-trisphosphate + ATP = 1D-myo-inositol-1,3,4,6-tetrakisphosphate + ADP

0

-

2.7.1.159

1D-myo-inositol-3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP

0

-

2.7.1.159

ATP + 1D-myo-inositol-1,3,4-trisphosphate = ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate

0

-

2.7.1.159

1D-myo-inositol-1,4,6-trisphosphate + 1D-myo-inositol-3,4,6-trisphosphate + 2 ATP = 2 1D-myo-inositol-1,3,4,6-tetrakisphosphate + 2 ADP

0

-

2.7.1.159

ATP + 1D-myo-inositol 1,4,6-trisphosphate + 1D-myo-inositol 3,4,6-trisphosphate = ADP + inositol tetrakisphosphate

0

-

2.7.1.159

8 entries

Substrate in Enzyme-catalyzed Reactions (11 results)

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Show Substrate (11 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.134

ATP + myo-inositol-1,3,4,6-tetrakisphosphate = ADP + myo-inositol-1,3,4,5-tetrakisphosphate

640821

-

2.7.1.140

ATP + myo-inositol 1,3,4,6-tetrakisphosphate = ADP + myo-inositol 1,3,4,5,6-pentakisphosphate

640974, 640971, 640973, 640815

-

2.7.1.151

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

640974, 660926, 686905, 662119

-

2.7.1.151

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate

686905

-

2.7.1.151

inositol (1,3,4,6)-tetrakisphosphate + ATP = ADP + inositol (1,3,4,5,6)-pentakisphosphate

660926

-

2.7.1.151

inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP

393219

-

2.7.1.151

4 entries

2.7.1.158

ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ?

738589

-

2.7.1.159

1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol-1,3,4,5,6-pentakisphosphate + ADP

690054

-

2.7.1.159

ATP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate = ADP + 1D-myo-inositol-1,3,4,5,6-pentakisphosphate

659473

-

2.7.1.159

2 entries

3.1.3.26

inositol tetrakisphosphate + H2O = ?

94796

-

3.1.3.62

inositol 1,3,4,6-tetrakisphosphate + H2O = ?

646432

-

Product in Enzyme-catalyzed Reactions (14 results)

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Show Product (14 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.134

ATP + 1D-myo-inositol 1,4,6-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

0

-

2.7.1.134

ATP + 1D-myo-inositol 3,4,6-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

0

-

2.7.1.134

ATP + myo-inositol-1,3,4-trisphosphate = ADP + myo-inositol-1,3,4,6-tetrakisphosphate

640816, 640818

-

2.7.1.134

ATP + myo-inositol-3,4,6-trisphosphate = ADP + myo-inositol-1,3,4,6-tetrakisphosphate

0, 640821

-

2.7.1.134

4 entries

2.7.1.151

ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

0

-

2.7.1.159

1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP

0

-

2.7.1.159

ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

0

-

2.7.1.159

1D-myo-inositol-1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP

0

-

2.7.1.159

1D-myo-inositol-1,3,4-trisphosphate + ATP = 1D-myo-inositol-1,3,4,6-tetrakisphosphate + ADP

0

-

2.7.1.159

1D-myo-inositol-1,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP

0

-

2.7.1.159

1D-myo-inositol-3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol-1,3,4,6-tetrakisphosphate + ATP

0

-

2.7.1.159

ATP + 1D-myo-inositol-1,3,4-trisphosphate = ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate

0

-

2.7.1.159

1D-myo-inositol-1,4,6-trisphosphate + 1D-myo-inositol-3,4,6-trisphosphate + 2 ATP = 2 1D-myo-inositol-1,3,4,6-tetrakisphosphate + 2 ADP

0

-

2.7.1.159

ATP + 1D-myo-inositol 1,4,6-trisphosphate + 1D-myo-inositol 3,4,6-trisphosphate = ADP + inositol tetrakisphosphate

0

-

2.7.1.159

9 entries

Inhibitor in Enzyme-catalyzed Reactions (3 results)

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Show Inhibitors (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.134

0.1 mM, more than 80% inhibition

640818

-

2.7.1.134

competitive inhibition

640817

-

2.7.1.134

2 entries

2.7.1.159

competitive

662090

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.7.1.158

0.4581

-

wild type enzyme, at pH 7.5 and 25°C

738589

K_M Value (5 results)

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Show KM Value (5 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.140

0.0003

-

pH 7.2, 37°C

640974

2.7.1.151

0.000295

-

37°C, pH 7.2

660926

2.7.1.151

0.0003

-

recombinant enzyme, pH 7.2, 37°C

640974, 660926

2.7.1.151

2 entries

2.7.1.158

0.06681

-

wild type enzyme, at pH 7.5 and 25°C

738589

2.7.1.159

0.042

-

-

673698

K_i Value (2 results)

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Show KI Value (2 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.134

0.015

-

pH 7.2, 37°C

640817

2.7.1.159

0.002

0.003

pH 7.2, 37°C, versus 1D-myo-inositol-1,3,4-trisphosphate

662090

References & Links

Literature References (19)

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Show Reference (19 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

94796

-

Isolation, purification and characterization of phytase from germinating mung beans

1972

Mandal, N.C.; Burman, S.; Biswas, B.B.

Phytochemistry

11

495-502

393219

-

Purification of phosphoinositol kinase from suspension-cultured cells of rice (Oryza sativa L.)

1995

Yotsushima, K.; Mitsui, T.; Hayakawa, T.

Biosci. Biotechnol. Biochem.

59

1953-1955

640815

2722840

Structures and metabolism of inositol tetrakisphosphates and inositol pentakisphosphate in bovine adrenal glomerulosa cells

1989

Balla, T.; Hunyadi, L.; Baukal, A.J.; Catt, K.J.

J. Biol. Chem.

264

9386-9390

640816

8662638

Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning, and expression of the recombinant enzyme

1996

Wilson, M.P.; Majerus, P.W.

J. Biol. Chem.

271

11904-11910

640817

8999935

Properties of the inositol 3,4,5,6-tetrakisphosphate 1-kinase purified from rat liver. Regulation of enzyme activity by inositol 1,3,4-trisphosphate

1997

Tan, Z.; Bruzik, K.S.; Shears, S.B.

J. Biol. Chem.

272

2285-2290

640818

-

Identification of inositol 1,3,4-trisphosphate 5-kinase and inositol 1,3,4,5-tetrakisphosphate 6-kinase in immature soybean seeds

1998

Phillippy, B.Q.

Plant Physiol.

116

291-297

640821

11909533

Regulation of ins(3,4,5,6)P4 signaling by a reversible kinase/phosphatase

2002

Ho, M.W.Y.; Yang, X.; Carew, M.A.; Zhang, T.; Hua, L.; Kwon, Y-U.; Chung, S-K.; Adelt, S.; Vogel, G.; Riley, a.M.; Potter, B.V.L.; Shears, S.B.

Curr. Biol.

12

477-482

640971

2584198

The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase

1989

Shears, S.B.

J. Biol. Chem.

264

19879-19886

640973

2845930

Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation

1988

Stephens, L.R.; Hawkins, P.T.; Barker, C.J.; Downes, C.P.

Biochem. J.

253

721-733

640974

12223481

The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase

2002

Chang, S.C.; Miller, A.L.; Feng, Y.; Wente, S.R.; Majerus, P.W.

J. Biol. Chem.

277

43836-43843

646432

1653239

Purification of an inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity from rat liver and the evaluation of its substrate specificity

1991

Nogimori, K.; Hughes, P.J.; Glennon, M.C.; Hodgson, M.E.; Putney, J.W.; Shears, S.B.

J. Biol. Chem.

266

16499-16506

659473

15531582

The pathway for the production of inositol hexakisphosphate in human cells

2005

Verbsky, J.W.; Chang, S.C.; Wilson, M.P.; Mochizuki, Y.; Majerus, P.W.

J. Biol. Chem.

280

1911-1920

660926

16293229

Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate

2006

Chang, S.C.; Majerus, P.W.

Biochem. Biophys. Res. Commun.

339

209-216

662090

1331051

Purification and characterization of inositol-1,3,4-trisphosphate 5/6-kinase from rat liver using an inositol hexakisphosphate affinity column

1992

Abdullah, M.; Hughes, P.J.; Craxton, A.; Gigg, R.; Desai, T.; Marecek, J.F.; Prestwich, G.D.; Shears, S.B.

J. Biol. Chem.

267

22340-22345

662119

12226109

Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases

2002

Stevenson-Paulik, J.; Odom, A.R.; York, J.D.

J. Biol. Chem.

277

42711-42718

673698

17698066

Arabidopsis thaliana inositol 1,3,4-trisphosphate 5/6-kinase 4 (AtITPK4) is an outlier to a family of ATP-grasp fold proteins from Arabidopsis

2007

Sweetman, D.; Stavridou, I.; Johnson, S.; Green, P.; Caddick, S.E.; Brearley, C.A.

FEBS Lett.

581

4165-4171

686905

17981594

Inositol polyphosphate multikinase: metabolic architect of nuclear inositides

2008

Resnick, A.C.; Saiardi, A.

Front. Biosci.

13

856-866

690054

18272466

Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels

2008

Saiardi, A.; Cockcroft, S.

Sci. Signal.

1

1-3

738589

23884422

Roles of phosphate recognition in inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) substrate binding and activation

2013

Gosein, V.; Miller, G.J.

J. Biol. Chem.

288

26908-26913

Links to other databases for myo-inositol 1,3,4,6-tetrakisphosphate

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Show Links (1 entry)

ChEBI

PubChem