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Information on EC 2.5.1.151 - alkylcobalamin dealkylase

for references in articles please use BRENDA:EC2.5.1.151
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IUBMB Comments
This mammalian enzyme, which is cytosolic, can bind internalized alkylcobalamins and process them to cob(I)alamin using the thiolate of glutathione for nucleophilic displacement. The product remains bound to the protein, and, following its oxidation to cob(II)alamin, is transferred by the enzyme, together with its interacting partner MMADHC, directly to downstream enzymes involved in adenosylcobalamin and methylcobalamin biosynthesis. In addition to its dealkylase function, the enzyme also catalyse an entirely different decyanase reaction with cyanocobalamin [cf. EC 1.16.1.6, cyanocobalamin reductase (cyanide-eliminating)].
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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[alkylcobalamin reductase]
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cob(I)alamin-[alkylcobalamin reductase]
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Synonyms
cblC, MMACHC, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an alkylcobalamin + [alkylcobalamin reductase] + glutathione = cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione
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