EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.5.1.151 | 5'-deoxyadenosylcobalamin + [alkylcobalamin reductase] + glutathione |
- |
Homo sapiens |
cob(I)alamin-[alkylcobalamin reductase] + S-5'-deoxyadenosylglutathione |
- |
? |
| 2.5.1.151 | 5'-deoxyadenosylcobalamin + [alkylcobalamin reductase] + glutathione |
- |
Bos taurus |
cob(I)alamin-[alkylcobalamin reductase] + S-5'-deoxyadenosylglutathione |
- |
? |
| 2.5.1.151 | 5'-deoxyadenosylcobalamin + [alkylcobalamin reductase] + glutathione |
the enzyme can bind internalized alkylcobalamins and process them to cob(I)alamin using the thiolate of glutathione for nucleophilic displacement. The product remains bound to the protein, and, following its oxidation to cob(II)alamin, is transferred by the enzyme, together with its interacting partner MMADHC (a cytosolic cobalamin trafficking chaperone), directly to downstream enzymes involved in adenosylcobalamin and methylcobalamin biosynthesis. Biologically relevant thiols, e.g. cysteine and homocysteine, cannot substitute for glutathione |
Homo sapiens |
cob(I)alamin-[alkylcobalamin reductase] + S-5'-deoxyadenosylglutathione |
- |
? |
| 2.5.1.151 | an alkylcobalamin + [alkylcobalamin reductase] + glutathione |
the CblC protein is responsible for alkylcobalamins dealkylation in mammalian cells |
Homo sapiens |
cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione |
- |
? |
| 2.5.1.151 | an alkylcobalamin + [alkylcobalamin reductase] + glutathione |
the CblC protein is responsible for alkylcobalamins dealkylation in mammalian cells |
Bos taurus |
cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione |
- |
? |
| 2.5.1.151 | an alkylcobalamin + [alkylcobalamin reductase] + glutathione |
the enzyme is involved in the cobalamin-processing pathway. It acts as a a cytosolic cobalamin trafficking chaperone |
Homo sapiens |
cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione |
- |
? |
| 2.5.1.151 | butyrylcobalamin + [alkylcobalamin reductase] + glutathione |
- |
Homo sapiens |
cob(I)alamin-[alkylcobalamin reductase] + S-butyrylglutathione |
- |
? |
| 2.5.1.151 | butyrylcobalamin + [alkylcobalamin reductase] + glutathione |
- |
Bos taurus |
cob(I)alamin-[alkylcobalamin reductase] + S-butyrylglutathione |
- |
? |
| 2.5.1.151 | butyrylcobalamin + [alkylcobalamin reductase] + glutathione |
the enzyme can bind internalized alkylcobalamins and process them to cob(I)alamin using the thiolate of glutathione for nucleophilic displacement. The product remains bound to the protein, and, following its oxidation to cob(II)alamin, is transferred by the enzyme, together with its interacting partner MMADHC, directly to downstream enzymes involved in adenosylcobalamin and methylcobalamin biosynthesis. Biologically relevant thiols, e.g. cysteine and homocysteine, cannot substitute for glutathione |
Homo sapiens |
cob(I)alamin-[alkylcobalamin reductase] + S-butyrylglutathione |
- |
? |
| 2.5.1.151 | ethylcobalamin + [alkylcobalamin reductase] + glutathione |
- |
Homo sapiens |
cob(I)alamin-[alkylcobalamin reductase] + S-ethylglutathione |
- |
? |
