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dimethylallyl diphosphate + 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
dimethylallyl diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
diphosphate + 3,5-dihydroxy-4,4-bis(3-methylbut-2-en-1-yl)-2-(2-methylpropanoyl)cyclohexa-2,5-dien-1-one
dimethylallyl diphosphate + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
dimethylallyl diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
diphosphate + 3,5-dihydroxy-2-(3-methylbutanoyl)-4,4-bis(3-methylbut-2-en-1-yl)cyclohexa-2,5-dien-1-one
dimethylallyl diphosphate + naringenin chalcone
diphosphate + desmethylxanthohumol
-
-
-
?
dimethylallyl diphosphate + phenyl(2,4,6-trihydroxyphenyl)methanone
diphosphate + phenyl[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]methanone
dimethylallyl diphosphate + phenyl[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]methanone
diphosphate + 2-benzoyl-3,5-dihydroxy-4,4-bis(3-methylbut-2-en-1-yl)cyclohexa-2,5-dien-1-one
-
-
-
?
dimethylallyl diphosphate + phlorisobutyrophenone
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
dimethylallyl diphosphate + phlorisovalerophenone
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
dimethylallyl diphosphate + phlormethylbutanophenone
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
29.5% of the activity with phlorisovalerophenone
-
-
?
farnesyl diphosphate + 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]phenyl]propan-1-one
-
-
-
?
farnesyl diphosphate + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]phenyl]butan-1-one
-
-
-
?
farnesyl diphosphate + phenyl(2,4,6-trihydroxyphenyl)methanone
diphosphate + phenyl[2,4,6-trihydroxy-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]phenyl]methanone
-
-
-
?
geranyl diphosphate + 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
diphosphate + 1-[3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,4,6-trihydroxyphenyl]-2-methylpropan-1-one
-
-
-
?
geranyl diphosphate + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
diphosphate + 1-[3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,4,6-trihydroxyphenyl]-3-methylbutan-1-one
-
-
-
?
geranyl diphosphate + phenyl(2,4,6-trihydroxyphenyl)methanone
diphosphate + [3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,4,6-trihydroxyphenyl](phenyl)methanone
-
-
-
?
geranyl diphosphate + phlorisovalerophenone
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-geranylphenyl]propan-1-one
-
-
-
?
dimethylallyl diphosphate + 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one

diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
-
-
?
dimethylallyl diphosphate + 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
-
-
?
dimethylallyl diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one

diphosphate + 3,5-dihydroxy-4,4-bis(3-methylbut-2-en-1-yl)-2-(2-methylpropanoyl)cyclohexa-2,5-dien-1-one
-
-
-
?
dimethylallyl diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
diphosphate + 3,5-dihydroxy-4,4-bis(3-methylbut-2-en-1-yl)-2-(2-methylpropanoyl)cyclohexa-2,5-dien-1-one
-
-
-
?
dimethylallyl diphosphate + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one

diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
-
-
-
?
dimethylallyl diphosphate + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
-
-
-
?
dimethylallyl diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one

diphosphate + 3,5-dihydroxy-2-(3-methylbutanoyl)-4,4-bis(3-methylbut-2-en-1-yl)cyclohexa-2,5-dien-1-one
-
-
-
?
dimethylallyl diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
diphosphate + 3,5-dihydroxy-2-(3-methylbutanoyl)-4,4-bis(3-methylbut-2-en-1-yl)cyclohexa-2,5-dien-1-one
-
-
-
?
dimethylallyl diphosphate + phenyl(2,4,6-trihydroxyphenyl)methanone

diphosphate + phenyl[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]methanone
-
-
-
?
dimethylallyl diphosphate + phenyl(2,4,6-trihydroxyphenyl)methanone
diphosphate + phenyl[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]methanone
-
-
-
?
dimethylallyl diphosphate + phlorisobutyrophenone

diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
-
-
-
?
dimethylallyl diphosphate + phlorisobutyrophenone
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
-
-
?
dimethylallyl diphosphate + phlorisobutyrophenone
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
61.9% of the activity with phlorisovalerophenone
-
-
?
dimethylallyl diphosphate + phlorisovalerophenone

diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
-
-
-
?
dimethylallyl diphosphate + phlorisovalerophenone
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
-
-
?
dimethylallyl diphosphate + phlorisovalerophenone
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
best substrate
-
-
?
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0.16 - 0.38
2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
0.42
3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
with farnesyl diphosphate as cosubstrate, at pH 7.5 and 37ưC
0.0435 - 0.071
dimethylallyl diphosphate
0.0057 - 0.46
geranyl diphosphate
0.47 - 0.7
phenyl(2,4,6-trihydroxyphenyl)methanone
-
0.0051 - 0.00668
phlorisobutyrophenone
0.00136 - 0.00339
phlorisovalerophenone
0.16
2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one

with dimethylallyl diphosphate as cosubstrate, at pH 7.5 and 37ưC
0.38
2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
with farnesyl diphosphate as cosubstrate, at pH 7.5 and 37ưC
0.0435
dimethylallyl diphosphate

truncated recombinant protein, pH 7.0, 30ưC
0.0436
dimethylallyl diphosphate
presence of prenyltransferase PT2, pH 7.0, 30ưC
0.071
dimethylallyl diphosphate
with 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one as cosubstrate, at pH 7.5 and 37ưC
0.0057
geranyl diphosphate

truncated recombinant protein, pH 7.0, 30ưC
0.00618
geranyl diphosphate
presence of prenyltransferase PT2, pH 7.0, 30ưC
0.46
geranyl diphosphate
with phenyl(2,4,6-trihydroxyphenyl)methanone as cosubstrate, at pH 7.5 and 37ưC
0.47
phenyl(2,4,6-trihydroxyphenyl)methanone

with geranyl diphosphate as cosubstrate, at pH 7.5 and 37ưC
-
0.7
phenyl(2,4,6-trihydroxyphenyl)methanone
with farnesyl diphosphate as cosubstrate, at pH 7.5 and 37ưC
-
0.0051
phlorisobutyrophenone

truncated recombinant protein, pH 7.0, 30ưC
0.00668
phlorisobutyrophenone
presence of prenyltransferase PT2, pH 7.0, 30ưC
0.00136
phlorisovalerophenone

truncated recombinant protein, pH 7.0, 30ưC
0.00339
phlorisovalerophenone
presence of prenyltransferase PT2, pH 7.0, 30ưC
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0.014 - 0.284
2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
0.012
3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
with farnesyl diphosphate as cosubstrate, at pH 7.5 and 37ưC
0.27
dimethylallyl diphosphate
0.126
geranyl diphosphate
0.012 - 0.137
phenyl(2,4,6-trihydroxyphenyl)methanone
-
0.014
2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one

with farnesyl diphosphate as cosubstrate, at pH 7.5 and 37ưC
0.284
2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
with dimethylallyl diphosphate as cosubstrate, at pH 7.5 and 37ưC
0.27
dimethylallyl diphosphate

with 1 as cosubstrate, at pH 7.5 and 37ưC
0.27
dimethylallyl diphosphate
with 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one as cosubstrate, at pH 7.5 and 37ưC
0.126
geranyl diphosphate

with 3 as cosubstrate, at pH 7.5 and 37ưC
0.126
geranyl diphosphate
with phenyl(2,4,6-trihydroxyphenyl)methanone as cosubstrate, at pH 7.5 and 37ưC
0.012
phenyl(2,4,6-trihydroxyphenyl)methanone

with farnesyl diphosphate as cosubstrate, at pH 7.5 and 37ưC
-
0.137
phenyl(2,4,6-trihydroxyphenyl)methanone
with geranyl diphosphate as cosubstrate, at pH 7.5 and 37ưC
-
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Tsurumaru, Y.; Sasaki, K.; Miyawaki, T.; Uto, Y.; Momma, T.; Umemoto, N.; Momose, M.; Yazaki, K.
HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops
Biochem. Biophys. Res. Commun.
417
393-398
2012
Humulus lupulus (E5RP65)
brenda
Zuurbier, K.; Fung, S.; Scheffer, J.; Verpoorte, R.
In-vitro prenylation of aromatic intermediates in the biosynthesis of bitter acids in Humulus lupulus
Phytochemistry
49
2315-2322
1998
Humulus lupulus
-
brenda
Tsurumaru, Y.; Sasaki, K.; Miyawaki, T.; Momma, T.; Umemoto, N.; Yazaki, K.
An aromatic prenyltransferase-like gene HlPT-1 preferentially expressed in lupulin glands of hop
Plant Biotechnol.
27
199-204
2010
Humulus lupulus (E5RP65)
-
brenda
Li, H.; Ban, Z.; Qin, H.; Ma, L.; King, A.J.; Wang, G.
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway
Plant Physiol.
167
650-659
2015
Humulus lupulus (A0A0B5A051)
brenda
Zhou, K.; Wunsch, C.; Dai, J.; Li, S.M.
gem-Diprenylation of acylphloroglucinols by a fungal prenyltransferase of the dimethylallyltryptophan synthase superfamily
Org. Lett.
19
388-391
2017
Aspergillus terreus (A0A1B0UHJ4), Aspergillus terreus DSM 1958 (A0A1B0UHJ4)
brenda