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dimethylallyl diphosphate + 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
dimethylallyl diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
diphosphate + 3,5-dihydroxy-4,4-bis(3-methylbut-2-en-1-yl)-2-(2-methylpropanoyl)cyclohexa-2,5-dien-1-one
dimethylallyl diphosphate + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
dimethylallyl diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
diphosphate + 3,5-dihydroxy-2-(3-methylbutanoyl)-4,4-bis(3-methylbut-2-en-1-yl)cyclohexa-2,5-dien-1-one
dimethylallyl diphosphate + naringenin chalcone
diphosphate + desmethylxanthohumol
-
-
-
?
dimethylallyl diphosphate + phenyl(2,4,6-trihydroxyphenyl)methanone
diphosphate + phenyl[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]methanone
dimethylallyl diphosphate + phenyl[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]methanone
diphosphate + 2-benzoyl-3,5-dihydroxy-4,4-bis(3-methylbut-2-en-1-yl)cyclohexa-2,5-dien-1-one
-
-
-
?
dimethylallyl diphosphate + phlorisobutyrophenone
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
dimethylallyl diphosphate + phlorisovalerophenone
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
dimethylallyl diphosphate + phlormethylbutanophenone
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
29.5% of the activity with phlorisovalerophenone
-
-
?
farnesyl diphosphate + 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]phenyl]propan-1-one
-
-
-
?
farnesyl diphosphate + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]phenyl]butan-1-one
-
-
-
?
farnesyl diphosphate + phenyl(2,4,6-trihydroxyphenyl)methanone
diphosphate + phenyl[2,4,6-trihydroxy-3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]phenyl]methanone
-
-
-
?
geranyl diphosphate + 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
diphosphate + 1-[3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,4,6-trihydroxyphenyl]-2-methylpropan-1-one
-
-
-
?
geranyl diphosphate + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
diphosphate + 1-[3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,4,6-trihydroxyphenyl]-3-methylbutan-1-one
-
-
-
?
geranyl diphosphate + phenyl(2,4,6-trihydroxyphenyl)methanone
diphosphate + [3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-2,4,6-trihydroxyphenyl](phenyl)methanone
-
-
-
?
geranyl diphosphate + phlorisovalerophenone
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-geranylphenyl]propan-1-one
-
-
-
?
dimethylallyl diphosphate + 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one

diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
-
-
?
dimethylallyl diphosphate + 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
-
-
?
dimethylallyl diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one

diphosphate + 3,5-dihydroxy-4,4-bis(3-methylbut-2-en-1-yl)-2-(2-methylpropanoyl)cyclohexa-2,5-dien-1-one
-
-
-
?
dimethylallyl diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
diphosphate + 3,5-dihydroxy-4,4-bis(3-methylbut-2-en-1-yl)-2-(2-methylpropanoyl)cyclohexa-2,5-dien-1-one
-
-
-
?
dimethylallyl diphosphate + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one

diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
-
-
-
?
dimethylallyl diphosphate + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
-
-
-
?
dimethylallyl diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one

diphosphate + 3,5-dihydroxy-2-(3-methylbutanoyl)-4,4-bis(3-methylbut-2-en-1-yl)cyclohexa-2,5-dien-1-one
-
-
-
?
dimethylallyl diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]butan-1-one
diphosphate + 3,5-dihydroxy-2-(3-methylbutanoyl)-4,4-bis(3-methylbut-2-en-1-yl)cyclohexa-2,5-dien-1-one
-
-
-
?
dimethylallyl diphosphate + phenyl(2,4,6-trihydroxyphenyl)methanone

diphosphate + phenyl[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]methanone
-
-
-
?
dimethylallyl diphosphate + phenyl(2,4,6-trihydroxyphenyl)methanone
diphosphate + phenyl[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]methanone
-
-
-
?
dimethylallyl diphosphate + phlorisobutyrophenone

diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
-
-
-
?
dimethylallyl diphosphate + phlorisobutyrophenone
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
-
-
?
dimethylallyl diphosphate + phlorisobutyrophenone
diphosphate + 2-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
61.9% of the activity with phlorisovalerophenone
-
-
?
dimethylallyl diphosphate + phlorisovalerophenone

diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
-
-
-
?
dimethylallyl diphosphate + phlorisovalerophenone
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
-
-
-
?
dimethylallyl diphosphate + phlorisovalerophenone
diphosphate + 3-methyl-1-[2,4,6-trihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]propan-1-one
best substrate
-
-
?
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0.16 - 0.38
2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
0.42
3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
with farnesyl diphosphate as cosubstrate, at pH 7.5 and 37°C
0.0435 - 0.071
dimethylallyl diphosphate
0.0057 - 0.46
geranyl diphosphate
0.47 - 0.7
phenyl(2,4,6-trihydroxyphenyl)methanone
0.0051 - 0.00668
phlorisobutyrophenone
0.00136 - 0.00339
phlorisovalerophenone
0.16
2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one

with dimethylallyl diphosphate as cosubstrate, at pH 7.5 and 37°C
0.38
2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
with farnesyl diphosphate as cosubstrate, at pH 7.5 and 37°C
0.0435
dimethylallyl diphosphate

truncated recombinant protein, pH 7.0, 30°C
0.0436
dimethylallyl diphosphate
presence of prenyltransferase PT2, pH 7.0, 30°C
0.071
dimethylallyl diphosphate
with 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one as cosubstrate, at pH 7.5 and 37°C
0.0057
geranyl diphosphate

truncated recombinant protein, pH 7.0, 30°C
0.00618
geranyl diphosphate
presence of prenyltransferase PT2, pH 7.0, 30°C
0.46
geranyl diphosphate
with phenyl(2,4,6-trihydroxyphenyl)methanone as cosubstrate, at pH 7.5 and 37°C
0.47
phenyl(2,4,6-trihydroxyphenyl)methanone

with geranyl diphosphate as cosubstrate, at pH 7.5 and 37°C
0.7
phenyl(2,4,6-trihydroxyphenyl)methanone
with farnesyl diphosphate as cosubstrate, at pH 7.5 and 37°C
0.0051
phlorisobutyrophenone

truncated recombinant protein, pH 7.0, 30°C
0.00668
phlorisobutyrophenone
presence of prenyltransferase PT2, pH 7.0, 30°C
0.00136
phlorisovalerophenone

truncated recombinant protein, pH 7.0, 30°C
0.00339
phlorisovalerophenone
presence of prenyltransferase PT2, pH 7.0, 30°C
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0.014 - 0.284
2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
0.012
3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one
with farnesyl diphosphate as cosubstrate, at pH 7.5 and 37°C
0.27
dimethylallyl diphosphate
0.126
geranyl diphosphate
0.012 - 0.137
phenyl(2,4,6-trihydroxyphenyl)methanone
0.014
2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one

with farnesyl diphosphate as cosubstrate, at pH 7.5 and 37°C
0.284
2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one
with dimethylallyl diphosphate as cosubstrate, at pH 7.5 and 37°C
0.27
dimethylallyl diphosphate

with 1 as cosubstrate, at pH 7.5 and 37°C
0.27
dimethylallyl diphosphate
with 2-methyl-1-(2,4,6-trihydroxyphenyl)propan-1-one as cosubstrate, at pH 7.5 and 37°C
0.126
geranyl diphosphate

with 3 as cosubstrate, at pH 7.5 and 37°C
0.126
geranyl diphosphate
with phenyl(2,4,6-trihydroxyphenyl)methanone as cosubstrate, at pH 7.5 and 37°C
0.012
phenyl(2,4,6-trihydroxyphenyl)methanone

with farnesyl diphosphate as cosubstrate, at pH 7.5 and 37°C
0.137
phenyl(2,4,6-trihydroxyphenyl)methanone
with geranyl diphosphate as cosubstrate, at pH 7.5 and 37°C
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Tsurumaru, Y.; Sasaki, K.; Miyawaki, T.; Uto, Y.; Momma, T.; Umemoto, N.; Momose, M.; Yazaki, K.
HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops
Biochem. Biophys. Res. Commun.
417
393-398
2012
Humulus lupulus (E5RP65)
brenda
Zuurbier, K.; Fung, S.; Scheffer, J.; Verpoorte, R.
In-vitro prenylation of aromatic intermediates in the biosynthesis of bitter acids in Humulus lupulus
Phytochemistry
49
2315-2322
1998
Humulus lupulus
-
brenda
Tsurumaru, Y.; Sasaki, K.; Miyawaki, T.; Momma, T.; Umemoto, N.; Yazaki, K.
An aromatic prenyltransferase-like gene HlPT-1 preferentially expressed in lupulin glands of hop
Plant Biotechnol.
27
199-204
2010
Humulus lupulus (E5RP65)
-
brenda
Li, H.; Ban, Z.; Qin, H.; Ma, L.; King, A.J.; Wang, G.
A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway
Plant Physiol.
167
650-659
2015
Humulus lupulus (A0A0B5A051)
brenda
Zhou, K.; Wunsch, C.; Dai, J.; Li, S.M.
gem-Diprenylation of acylphloroglucinols by a fungal prenyltransferase of the dimethylallyltryptophan synthase superfamily
Org. Lett.
19
388-391
2017
Aspergillus terreus (A0A1B0UHJ4), Aspergillus terreus DSM 1958 (A0A1B0UHJ4)
brenda