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Information on EC 2.4.1.33 - mannuronan synthase for references in articles please use BRENDA:EC2.4.1.33Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
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GDP-alpha-D-mannuronate + [(1->4)-beta-D-mannuronosyl]n = GDP + [(1->4)-beta-D-mannuronosyl]n+1
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hexosyl group transfer
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alginate biosynthesis I (algal)
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alginate biosynthesis II (bacterial)
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alginate biosynthesis
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Fructose and mannose metabolism
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GDP-alpha-D-mannuronate:mannuronan D-mannuronatetransferase
The enzyme catalyses the polymerization of beta-D-mannuronate residues into a mannuronan polymer, an intermediate in the biosynthesis of alginate. It is found in brown algae and in alginate-producing bacterial species from the Pseudomonas and Azotobacter genera.
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mannuronosyl transferase
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synthase, alginate
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marine brown alga
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brenda
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brenda
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alpha-D-glucuronate 1-phosphate + (alginate)n
phosphate + ?
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25% of activity with GDP-D-mannuronate
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alpha-D-mannuronate 1-phosphate + (alginate)n
phosphate + (alginate)n+1
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25% of activity with GDP-D-mannuronate
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GDP-D-mannuronate + (alginate)n
GDP + (alginate)n+1
GDP-D-mannuronate + (alginate)n
GDP + (alginate)n+1
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GDP-D-mannuronate + (alginate)n
GDP + (alginate)n+1
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cytoplasmic membrane with a periplasmic C terminus
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GDP-D-mannuronate + (alginate)n
GDP + (alginate)n+1
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ir
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MnCl2
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no essential requirement, at 0.25 mM: 15% increase of activity, inhibition above 0.75 mM
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MnCl2
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at 0.25 mM: 15% increase of activity, above 0.75 mM: 80% inhibition
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5'-GMP
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slight stimulation
GDP
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0.3 mM: 15% stimulation
additional information
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GTP, UTP, CTP, TTP, a mixture of NAD+ and NADP+ have no significant effect
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5.6 - 8.5
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65% of maximal activity at pH 5.6 and pH 8.5
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brenda
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Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1);
Q9HY69
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1);
Q9HY69
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1);
Q9HY69
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1);
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10
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15 min, 23% remaining activity
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15 min, 72% remaining activity
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15 min, 60% remaining activity
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-15°C, 3 days, 80% remaining activity
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ALG44_PSEAE
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
389
41787
Swiss-Prot
ALG8_PSEAE
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
494
56456
Swiss-Prot
A0A2H6AXV4_9BACT
508
57836
TrEMBL
A0A2R8BCF9_9RHOB
527
60394
TrEMBL
W5Z0F2_9ALTE
494
56444
TrEMBL
A0A2H6AXT3_9BACT
349
38127
TrEMBL
A0A1Z4GTN6_9CYAN
685
77918
TrEMBL
A0A1W6KEX0_9ALTE
393
42895
TrEMBL
A0A2R8API9_9RHOB
490
56141
TrEMBL
A0A2H6AS71_9BACT
344
37785
TrEMBL
A0A2H6AS78_9BACT
505
56145
TrEMBL
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Lin, T.Y.; Hassid, W.Z.
Pathway of alginic acid synthesis in the marine brown alga, Fucus gardneri Silva
J. Biol. Chem.
241
5284-5297
1966
Fucus gardneri
brenda
Remminghorst, U.; Rehm, B.H.
In vitro alginate polymerization and the functional role of Alg8 in alginate production by Pseudomonas aeruginosa
Appl. Environ. Microbiol.
72
298-305
2006
Pseudomonas aeruginosa
brenda
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