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Information on EC 2.4.1.146 - beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase

for references in articles please use BRENDA:EC2.4.1.146
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IUBMB Comments
The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 2 structure of O-glycans.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
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3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Synonyms
acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-mucin beta(1-3)- (elongating), beta1,3-N-acetylglucosaminyltransferase 3, beta3GlcNAc-T (elongation), core 1 extension beta1,3-N-acetylglucosaminyltransferase, core 1 extension enzyme, core1-beta3GlcNAcT, elongation 3beta-GalNAc transferase, elongation 3beta-GalNAc-transferase, elongation beta3 Gn-T, extended C1 beta3GnT3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] = UDP + 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
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PATHWAY SOURCE
PATHWAYS
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