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Information on EC 2.4.1.13 - sucrose synthase and Organism(s) Solanum lycopersicum and UniProt Accession P49037

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.13 sucrose synthase
IUBMB Comments
Although UDP is generally considered to be the preferred nucleoside diphosphate for sucrose synthase, numerous studies have shown that ADP serves as an effective acceptor molecule to produce ADP-glucose [3-9]. Sucrose synthase has a dual role in producing both UDP-glucose (necessary for cell wall and glycoprotein biosynthesis) and ADP-glucose (necessary for starch biosynthesis) .
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This record set is specific for:
Solanum lycopersicum
UNIPROT: P49037
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The taxonomic range for the selected organisms is: Solanum lycopersicum
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
sucrose synthase, sucrose synthetase, mtsucs1, susy1, rsus3, sucrose synthase 1, psnsusy2, susy2, sucrose synthase 2, sucrose synthase 3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glucosyltransferase, uridine diphosphoglucose-fructose
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sucrose synthetase
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sucrose-UDP glucosyltransferase
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sucrose-uridine diphosphate glucosyltransferase
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Sus
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SuSy
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UDP-glucose-fructose glucosyltransferase
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UDP-glucose:D-fructose 2-alpha-D-glucosyltransferase
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uridine diphosphoglucose-fructose glucosyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase
Although UDP is generally considered to be the preferred nucleoside diphosphate for sucrose synthase, numerous studies have shown that ADP serves as an effective acceptor molecule to produce ADP-glucose [3-9]. Sucrose synthase has a dual role in producing both UDP-glucose (necessary for cell wall and glycoprotein biosynthesis) and ADP-glucose (necessary for starch biosynthesis) [10].
CAS REGISTRY NUMBER
COMMENTARY hide
9030-05-1
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP + sucrose
UDP-glucose + D-fructose
show the reaction diagram
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?
UDP-glucose + D-fructose
UDP + sucrose
show the reaction diagram
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?
UDPglucose + D-fructose
UDP + sucrose
show the reaction diagram
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r
UDP + sucrose
UDP-glucose + D-fructose
show the reaction diagram
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?
UDPglucose + D-fructose
UDP + sucrose
show the reaction diagram
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r
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-glucose + D-fructose
UDP + sucrose
show the reaction diagram
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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enzyme exists as monophosphorylated and multiphosphorylated form, multiphopsphorylation increases affinity for UDP up to threefold
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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a mechanism involving protein phosphorylation/dephosphorylation and/or calcium would in part control the association of the isoforms of sucrose synthase with membranes in developing fruit
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SUS_SOLLC
805
0
92446
Swiss-Prot
Mitochondrion (Reliability: 3)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
comparison of structure and active site of starch, glycogen, sucrose synthases
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
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11 phosphorylation sites. The enzyme is largely dephosphorylated in fruits fed EDTA or staurosporine, compared to fruits fed water or sucrose
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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root restriction treatment increases the enzyme expression, while it reduces cytochrome pathway, and alternative pathway respirations with reduced ATP content. The ratio of invertase/sucrose synthase activity is increased in the restricted roots together with a decrease in glucose content and an increase in fructose content
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, phylogenetic analysis
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
root restriction treatment increases the enzyme expression, while it reduces cytochrome pathway, and alternative pathway respirations with reduced ATP content. The ratio of invertase/sucrose synthase activity is increased in the restricted roots together with a decrease in glucose content and an increase in fructose content
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
MacGregor, E.A.
Possible structure and active site residues of starch, glycogen, and sucrose synthases
J. Protein Chem.
21
297-306
2002
Solanum lycopersicum (P49037)
Manually annotated by BRENDA team
Anguenot, R.; Yelle, S.; Nguyen-Quoc, B.
Purification of tomato sucrose synthase phosphorylated isoforms by Fe(III)-immobilized metal affinity chromatography
Arch. Biochem. Biophys.
365
163-169
1999
Solanum lycopersicum
Manually annotated by BRENDA team
Anguenot, R.; Nguyen-Quoc, B.; Yelle, S.; Michaud, D.
Protein phosphorylation and membrane association of sucrose synthase in developing tomato fruit
Plant Physiol. Biochem.
44
294-300
2006
Solanum lycopersicum
Manually annotated by BRENDA team
Abid, G.; Silue, S.; Muhovski, Y.; Jacquemin, J.M.; Toussaint, A.; Baudoin, J.P.
Role of myo-inositol phosphate synthase and sucrose synthase genes in plant seed development
Gene
439
1-10
2009
Arabidopsis thaliana (F4K5W8), Arabidopsis thaliana (P49040), Arabidopsis thaliana (Q00917), Citrus unshiu (Q9SLY2), Citrus x paradisi, Coffea arabica (Q0E7D4), Daucus carota (O49845), Eucalyptus grandis (Q00P15), Eucalyptus grandis (Q00P16), Glycine max (P13708), Glycine max, Gossypium hirsutum (Q9XGB7), Gossypium hirsutum, Oryza sativa (P31924), Pisum sativum (O24301), Pisum sativum (O81610), Pisum sativum (Q9AVR8), Pisum sativum (Q9T0M9), Solanum lycopersicum (P49037), Solanum tuberosum (Q84T18), Vicia faba (P31926), Zea mays
Manually annotated by BRENDA team
Shi, K.; Fu, L.J.; Dong, D.K.; Zhou, Y.H.; Yu, J.Q.
Decreased energy synthesis is partially compensated by a switch to sucrose synthase pathway of sucrose degradation in restricted root of tomato plants
Plant Physiol. Biochem.
46
1040-1044
2008
Solanum lycopersicum
Manually annotated by BRENDA team
Goren, S.; Huber, S.C.; Granot, D.
Comparison of a novel tomato sucrose synthase, SlSUS4, with previously described SlSUS isoforms reveals distinct sequence features and differential expression patterns in association with stem maturation
Planta
233
1011-1023
2011
Solanum lycopersicum (E0Z1D0), Solanum lycopersicum (E0Z1D1), Solanum lycopersicum
Manually annotated by BRENDA team