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Information on EC 2.4.1.12 - cellulose synthase (UDP-forming)
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EC Tree
2.4.1.12 cellulose synthase (UDP-forming)IUBMB Comments
Involved in the synthesis of cellulose. A similar enzyme utilizes GDP-glucose [EC 2.4.1.29 cellulose synthase (GDP-forming)].
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Word Map
- 2.4.1.12
-
cesas
- microfibrils
- synthases
- polysaccharide
- candida
- xylem
-
echinocandins
- microtubule
- cotton
- lignin
-
synthase-like
- hypocotyls
- chitin
- populus
- caspofungin
- acetobacter
- pectin
- hirsutum
- xyloglucan
- xylinum
- gossypium
- callose
- beta-glucans
- c-di-gmp
-
wall-related
- candidiasis
- diguanylate
- 1,3-beta-glucan
- micafungin
-
load-bearing
-
calcofluor
-
expansin
- beta-1,3-glucan
- anidulafungin
- gluconacetobacter
- hemicelluloses
- rho1
-
non-cellulosic
- aspen
- tremuloides
- analysis
-
tracheary
- cslc
- hansenii
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
cellulose synthase, glucan synthase, cesa3, cellulose synthase complex, cesa6, cesa1, cesa7, csld3, cellulose synthase a, cesa4, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1,4-beta-D-glucan synthase
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1,4-beta-glucan synthase
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AcsA
AcsAB
AcsB
BcsA-B
beta-1,4-glucan synthase
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beta-1,4-glucan synthetase
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beta-1,4-glucosyltransferase
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beta-glucan synthase
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cellulose syntethase
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cellulose synthase (UDP-forming)
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cellulose synthase (uridine diphosphate-forming)
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Ces A
CesA
CesA1
CesA2
CESA3
CESA4
CESA8
CslF
CslH
glucan synthase
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glucosyltransferase, uridine diphosphoglucose-1,4-beta-glucan
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GS-I
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GXY_04282
inner membrane-associated bacterial cellulose synthase
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UDP-glucose-1,4-beta-glucan glucosyltransferase
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UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase
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UDPglucose-beta-glucan glucosyltransferase
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UDPglucose-cellulose glucosyltransferase
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uridine diphosphoglucose-cellulose glucosyltransferase
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-
additional information
additional information
-
the enzyme belongs to the cellulose synthase-like, Csl, family
additional information
-
the enzyme belongs to the one cellulose synthase family CesA, the CesA family is part of the cellulose synthase superfamily together with nine cellulose synthase-like (Csl) families
additional information
-
the enzyme belongs to the cellulose synthase-like, Csl, family
additional information
-
the enzyme belongs to the cellulose synthase-like, Csl, family
additional information
-
the enzyme belongs to the one cellulose synthase family CesA, the CesA family is part of the cellulose synthase superfamily together with nine cellulose synthase-like (Csl) families
additional information
-
the enzyme belongs to the one cellulose synthase family CesA, the CesA family is part of the cellulose synthase superfamily together with nine cellulose synthase-like (Csl) families
additional information
-
the enzyme belongs to the one cellulose synthase family CesA, the CesA family is part of the cellulose synthase superfamily together with nine cellulose synthase-like (Csl) families
additional information
-
the enzyme belongs to the one cellulose synthase family CesA, the CesA family is part of the cellulose synthase superfamily together with nine cellulose synthase-like (Csl) families
additional information
-
the enzyme belongs to the one cellulose synthase family CesA, the CesA family is part of the cellulose synthase superfamily together with nine cellulose synthase-like (Csl) families
additional information
-
the enzyme belongs to the one cellulose synthase family CesA, the CesA family is part of the cellulose synthase superfamily together with nine cellulose synthase-like (Csl) families
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n = UDP + [(1->4)-beta-D-glucosyl]n+1
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hexosyl group transfer
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
UDP-glucose:(1->4)-beta-D-glucan 4-beta-D-glucosyltransferase
Involved in the synthesis of cellulose. A similar enzyme utilizes GDP-glucose [EC 2.4.1.29 cellulose synthase (GDP-forming)].
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CAS REGISTRY NUMBER
COMMENTARY
9027-19-4
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
?
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
-
?
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
-
?
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
-
?
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
?
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
-
?
UDP-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
?
UDP-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
-
?
UDP-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
involved in the synthesis of cellulose
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
additional information
?
-
-
cellulose synthase activity influences microtubule cortical array organization
-
-
?
additional information
?
-
phosphorylation and subsequent degradation via a proteasome dependant pathway is a possible mechanism by which plants regulate the relative levels of the different cellulose synthase catalytic subunits that are essential for cellulose synthesis
-
-
?
additional information
?
-
-
phosphorylation and subsequent degradation via a proteasome dependant pathway is a possible mechanism by which plants regulate the relative levels of the different cellulose synthase catalytic subunits that are essential for cellulose synthesis
-
-
?
additional information
?
-
procuste1 (prc1-1) cellulose deficient mutant of Arabidopsis is mutated in the cellulose synthase CESA6 gene resulting in a reduction in the cellulose content of the cell walls. RHD6 acts upstream of the normal cell wall loosening event which involves EXP7 expression. In the absence of a functional RHD6 the loosening and accompanying EXP7 expression is blocked. In the prc1-1 mutant background, the requirement for RHD6 during hair initiation is reduced which may result from a weaker cell wall structure mimicking the cell wall loosening events during hair formation
-
-
?
additional information
?
-
-
procuste1 (prc1-1) cellulose deficient mutant of Arabidopsis is mutated in the cellulose synthase CESA6 gene resulting in a reduction in the cellulose content of the cell walls. RHD6 acts upstream of the normal cell wall loosening event which involves EXP7 expression. In the absence of a functional RHD6 the loosening and accompanying EXP7 expression is blocked. In the prc1-1 mutant background, the requirement for RHD6 during hair initiation is reduced which may result from a weaker cell wall structure mimicking the cell wall loosening events during hair formation
-
-
?
additional information
?
-
-
cellulose synthase A is a catalytic component of the cellulose synthase complex
-
-
?
additional information
?
-
interactions between membrane-bound cellulose synthases involved in the synthesis of the secondary cell wall, overview
-
-
?
additional information
?
-
interactions between membrane-bound cellulose synthases involved in the synthesis of the secondary cell wall, overview
-
-
?
additional information
?
-
interactions between membrane-bound cellulose synthases involved in the synthesis of the secondary cell wall, overview
-
-
?
additional information
?
-
-
several genes from the cellulose synthase-like, Csl, family are involved in the synthesis of various hemicellulosic glycans. Mechanism of beta-glycan chain elongation, overview
-
-
?
additional information
?
-
presence of at least two types of cellulose biosynthesis machinery in wood formation
-
-
?
additional information
?
-
presence of at least two types of cellulose biosynthesis machinery in wood formation
-
-
?
additional information
?
-
presence of at least two types of cellulose biosynthesis machinery in wood formation
-
-
?
additional information
?
-
presence of at least two types of cellulose biosynthesis machinery in wood formation
-
-
?
additional information
?
-
presence of at least two types of cellulose biosynthesis machinery in wood formation
-
-
?
additional information
?
-
-
presence of at least two types of cellulose biosynthesis machinery in wood formation
-
-
?
additional information
?
-
-
several genes from the cellulose synthase-like, Csl, family are involved in the synthesis of various hemicellulosic glycans. Mechanism of beta-glycan chain elongation, overview
-
-
?
additional information
?
-
-
several genes from the cellulose synthase-like, Csl, family are involved in the synthesis of various hemicellulosic glycans. Mechanism of beta-glycan chain elongation, overview
-
-
?
additional information
?
-
-
Cellulose synthesis in Phytophthora infestans is required for normal appressorium formation and successful infection of potato
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?
additional information
?
-
UDP-glucose acts as glycosyl donor in glucan synthesis, product analysis
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-
?
additional information
?
-
UDP-glucose acts as glycosyl donor in glucan synthesis, product analysis
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-
?
additional information
?
-
-
UDP-glucose acts as glycosyl donor in glucan synthesis, product analysis
-
-
?
additional information
?
-
CesA2 binds in vitro to phosphoinositides, F-actin and microtubules via its PH domain, and co-localizes with F-actin in vivo
-
-
?
additional information
?
-
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CesA2 binds in vitro to phosphoinositides, F-actin and microtubules via its PH domain, and co-localizes with F-actin in vivo
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
?
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
-
?
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
-
?
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
-
?
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
?
UDP-alpha-D-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
-
?
UDP-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
?
UDP-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
-
?
UDP-glucose + [(1->4)-beta-D-glucosyl]n
UDP + [(1->4)-beta-D-glucosyl]n+1
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
involved in the synthesis of cellulose
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
UDPglucose + (1,4-beta-D-glucosyl)n
UDP + (1,4-beta-D-glucosyl)n+1
-
-
-
-
?
additional information
?
-
-
cellulose synthase activity influences microtubule cortical array organization
-
-
?
additional information
?
-
phosphorylation and subsequent degradation via a proteasome dependant pathway is a possible mechanism by which plants regulate the relative levels of the different cellulose synthase catalytic subunits that are essential for cellulose synthesis
-
-
?
additional information
?
-
-
phosphorylation and subsequent degradation via a proteasome dependant pathway is a possible mechanism by which plants regulate the relative levels of the different cellulose synthase catalytic subunits that are essential for cellulose synthesis
-
-
?
additional information
?
-
procuste1 (prc1-1) cellulose deficient mutant of Arabidopsis is mutated in the cellulose synthase CESA6 gene resulting in a reduction in the cellulose content of the cell walls. RHD6 acts upstream of the normal cell wall loosening event which involves EXP7 expression. In the absence of a functional RHD6 the loosening and accompanying EXP7 expression is blocked. In the prc1-1 mutant background, the requirement for RHD6 during hair initiation is reduced which may result from a weaker cell wall structure mimicking the cell wall loosening events during hair formation
-
-
?
additional information
?
-
-
procuste1 (prc1-1) cellulose deficient mutant of Arabidopsis is mutated in the cellulose synthase CESA6 gene resulting in a reduction in the cellulose content of the cell walls. RHD6 acts upstream of the normal cell wall loosening event which involves EXP7 expression. In the absence of a functional RHD6 the loosening and accompanying EXP7 expression is blocked. In the prc1-1 mutant background, the requirement for RHD6 during hair initiation is reduced which may result from a weaker cell wall structure mimicking the cell wall loosening events during hair formation
-
-
?
additional information
?
-
-
cellulose synthase A is a catalytic component of the cellulose synthase complex
-
-
?
additional information
?
-
interactions between membrane-bound cellulose synthases involved in the synthesis of the secondary cell wall, overview
-
-
?
additional information
?
-
interactions between membrane-bound cellulose synthases involved in the synthesis of the secondary cell wall, overview
-
-
?
additional information
?
-
interactions between membrane-bound cellulose synthases involved in the synthesis of the secondary cell wall, overview
-
-
?
additional information
?
-
-
several genes from the cellulose synthase-like, Csl, family are involved in the synthesis of various hemicellulosic glycans. Mechanism of beta-glycan chain elongation, overview
-
-
?
additional information
?
-
presence of at least two types of cellulose biosynthesis machinery in wood formation
-
-
?
additional information
?
-
presence of at least two types of cellulose biosynthesis machinery in wood formation
-
-
?
additional information
?
-
presence of at least two types of cellulose biosynthesis machinery in wood formation
-
-
?
additional information
?
-
presence of at least two types of cellulose biosynthesis machinery in wood formation
-
-
?
additional information
?
-
presence of at least two types of cellulose biosynthesis machinery in wood formation
-
-