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Information on EC 2.3.3.17 - methylthioalkylmalate synthase

for references in articles please use BRENDA:EC2.3.3.17

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IUBMB Comments

The enzyme, characterized from the plant Arabidopsis thaliana, is involved in the L-methionine side-chain elongation pathway, forming substrates for the biosynthesis of aliphatic glucosinolates. Two forms are known - MAM1 catalyses only only the first two rounds of methionine chain elongation, while MAM3 catalyses all six cycles, up to formation of L-hexahomomethionine.

The enzyme appears in viruses and cellular organisms

Synonyms
methylthioalkylmalate synthase, mam synthase, methylthioalkylmalate synthase1, methylthioalkylmalate synthase 1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an omega-(methylsulfanyl)-2-oxoalkanoate + acetyl-CoA + H2O = a 2-[omega-(methylsulfanyl)alkyl]malate + CoA
show the reaction diagram
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