Reference on EC 2.3.2.5 - glutaminyl-peptide cyclotransferase and Organism(s) Mus musculus and UniProt Accession Q9CYK2
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schilling, S.; Cynis, H.; von Bohlen, A.; Hoffmann, T.; Wermann, M.; Heiser, U.; Buchholz, M.; Zunkel, K.; Demuth, H.U.
Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase
Biochemistry
44
13415-13424
2005
Mus musculus (Q9CYK2), Mus musculus
Cynis, H.; Schilling, S.; Bodnar, M.; Hoffmann, T.; Heiser, U.; Saido, T.C.; Demuth, H.
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells
Biochim. Biophys. Acta
1764
1618-1625
2006
Homo sapiens, Mus musculus
Seifert, F.; Schulz, K.; Koch, B.; Manhart, S.; Demuth, H.U.; Schilling, S.
Glutaminyl cyclases display significant catalytic proficiency for glutamyl substrates
Biochemistry
48
11831-11833
2009
Carica papaya, Homo sapiens, Mus musculus, Solanum tuberosum
Stephan, A.; Wermann, M.; Von Bohlen, A.; Koch, B.; Cynis, H.; Demuth, H.; Schilling, S.
Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics
FEBS J.
276
6522-6536
2009
Homo sapiens, Mus musculus
Hartlage-Ruebsamen, M.; Staffa, K.; Waniek, A.; Wermann, M.; Hoffmann, T.; Cynis, H.; Schilling, S.; Demuth, H.U.; Rossner, S.
Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain
Int. J. Dev. Neurosci.
27
825-835
2009
Mus musculus
Hartlage-Ruebsamen, M.; Morawski, M.; Waniek, A.; Jaeger, C.; Zeitschel, U.; Koch, B.; Cynis, H.; Schilling, S.; Schliebs, R.; Demuth, H.U.; Rossner, S.
Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Abeta deposits in hippocampus via distinct cellular mechanisms
Acta Neuropathol.
121
705-719
2011
Homo sapiens, Mus musculus
Ruiz-Carrillo, D.; Koch, B.; Parthier, C.; Wermann, M.; Dambe, T.; Buchholz, M.; Ludwig, H.H.; Heiser, U.; Rahfeld, J.U.; Stubbs, M.T.; Schilling, S.; Demuth, H.U.
Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center
Biochemistry
50
6280-6288
2011
Homo sapiens (Q16769), Mus musculus (Q9CYK2)
Koch, B.; Buchholz, M.; Wermann, M.; Heiser, U.; Schilling, S.; Demuth, H.U.
Probing secondary glutaminyl cyclase (QC) inhibitor interactions applying an in silico-modeling/site-directed mutagenesis approach: implications for drug development
Chem. Biol. Drug Des.
80
937-946
2012
Homo sapiens (Q16769), Mus musculus (Q9CYK2)
Waniek, A.; Hartlage-Ruebsamen, M.; Hoefling, C.; Kehlen, A.; Schilling, S.; Demuth, H.U.; Rossner, S.
Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes
Biochim. Biophys. Acta
1852
146-155
2015
Mus musculus
Becker, A.; Eichentopf, R.; Sedlmeier, R.; Waniek, A.; Cynis, H.; Koch, B.; Stephan, A.; Baeuscher, C.; Kohlmann, S.; Hoffmann, T.; Kehlen, A.; Berg, S.; Freyse, E.J.; Osmand, A.; Plank, A.C.; Rossner, S.; von Hoersten, S.; Graubner, S.; Demuth, H.U.; Schilling, S.
IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes
Biol. Chem.
397
45-55
2016
Mus musculus
Hoefling, C.; Indrischek, H.; Hoepcke, T.; Waniek, A.; Cynis, H.; Koch, B.; Schilling, S.; Morawski, M.; Demuth, H.U.; Rossner, S.; Hartlage-Ruebsamen, M.
Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC
Int. J. Dev. Neurosci.
36
64-73
2014
Mus musculus
Hartlage-Ruebsamen, M.; Bluhm, A.; Piechotta, A.; Linnert, M.; Rahfeld, J.U.; Demuth, H.U.; Lues, I.; Kuhn, P.H.; Lichtenthaler, S.F.; Rossner, S.; Hoefling, C.
Immunohistochemical evidence from APP-transgenic mice for glutaminyl cyclase as drug target to diminish pE-Abeta formation
Molecules
23
924
2018
Mus musculus (Q9CYK2)
