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Information on EC 2.3.1.255 - N-terminal amino-acid Nalpha-acetyltransferase NatA and Organism(s) Arabidopsis thaliana and UniProt Accession Q9FKI4

for references in articles please use BRENDA:EC2.3.1.255
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EC Tree
IUBMB Comments
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. The NatA complex is found in all eukaryotic organisms, and specifically targets N-terminal Ala, Gly, Cys, Ser, Thr, and Val residues, that became available after removal of the initiator methionine.
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Arabidopsis thaliana
UNIPROT: Q9FKI4
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Word Map
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The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
hide(3 overall reactions are displayed. Show all (6)>>)
acetyl-CoA
+
an N-terminal-glycyl-[protein]
=
an N-terminal-Nalpha-acetyl-glycyl-[protein]
+
CoA
+
an N-terminal-glycyl-[protein]
=
an N-terminal-Nalpha-acetyl-glycyl-[protein]
+
acetyl-CoA
+
an N-terminal-L-alanyl-[protein]
=
an N-terminal-Nalpha-acetyl-L-alanyl-[protein]
+
CoA
+
an N-terminal-L-alanyl-[protein]
=
an N-terminal-Nalpha-acetyl-L-alanyl-[protein]
+
acetyl-CoA
+
an N-terminal-L-seryl-[protein]
=
an N-terminal-Nalpha-acetyl-L-seryl-[protein]
+
CoA
+
an N-terminal-L-seryl-[protein]
=
an N-terminal-Nalpha-acetyl-L-seryl-[protein]
+
Synonyms
naa15, ard1b, hnaa10, daf-31, naa11, n-terminal acetyltransferase a, arrest-defective protein 1, mtrimi, ta0058, n-alpha-acetyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
N-alpha-acetyltransferase 10
-
ARD1
-
-
-
-
MUSE6
-
auxiliary subunit of NatA
NAA10
NAA15
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:N-terminal-Gly/Ala/Ser/Val/Cys/Thr-[protein] Nalpha-acetyltransferase
N-terminal-acetylases (NATs) catalyse the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic. The NatA complex is found in all eukaryotic organisms, and specifically targets N-terminal Ala, Gly, Cys, Ser, Thr, and Val residues, that became available after removal of the initiator methionine.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + an N-terminal-methionyl-[RPM1 protein]
an N-terminal-Nalpha-acetyl-methionyl-[RPM1 protein] + CoA
show the reaction diagram
-
-
-
-
?
acetyl-CoA + an N-terminal-methionyl-[SNC1 protein]
an N-terminal-Nalpha-acetyl-methionyl-[SNC1 protein] + CoA
show the reaction diagram
-
NatA specifically acetylates the first met of SNC1 protein
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + an N-terminal-methionyl-[RPM1 protein]
an N-terminal-Nalpha-acetyl-methionyl-[RPM1 protein] + CoA
show the reaction diagram
-
-
-
-
?
acetyl-CoA + an N-terminal-methionyl-[SNC1 protein]
an N-terminal-Nalpha-acetyl-methionyl-[SNC1 protein] + CoA
show the reaction diagram
-
NatA specifically acetylates the first met of SNC1 protein
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
the naa10 knockout mutant naa10-1 shows growth retardation in vegetative stage, abortion of embryogenesis, and drought-adapted root morphology, the mutation is lethal. A knockout of naa15 causes the same phenotype
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NAA10_ARATH
192
0
21715
Swiss-Prot
Secretory Pathway (Reliability: 5)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
generation of mutant naa10-1 and of a naa15 mutant by T-DNA insertion-disrupting gene expression
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli Rosetta Star cells
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xu, F.; Huang, Y.; Li, L.; Gannon, P.; Linster, E.; Huber, M.; Kapos, P.; Bienvenut, W.; Polevoda, B.; Meinnel, T.; Hell, R.; Giglione, C.; Zhang, Y.; Wirtz, M.; Chen, S.; Li, X.
Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis
Plant Cell
27
1547-1562
2015
Arabidopsis thaliana
Manually annotated by BRENDA team
Lee, M.N.; Kweon, H.Y.; Oh, G.T.
N-alpha-acetyltransferase 10 (NAA10) in development the role of NAA10
Exp. Mol. Med.
50
1-11
2018
Arabidopsis thaliana (Q9FKI4), Caenorhabditis elegans (O61219), Caenorhabditis elegans DAF-31 (O61219), Danio rerio (Q7T3B8), Drosophila melanogaster (Q9VT75), Homo sapiens (P41227), Mus musculus (Q3UX61), Mus musculus (Q9QY36), Mus musculus C57Bl6/J (Q3UX61), Mus musculus C57Bl6/J (Q9QY36), Saccharomyces cerevisiae (P07347 AND P12945), Saccharomyces cerevisiae ATCC 204508 (P07347 AND P12945), Trypanosoma brucei (Q9NFL8)
Manually annotated by BRENDA team