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IUBMB CommentsThe enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family.
The enzyme appears in viruses and cellular organisms
Synonyms
FgaAT, more
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FgaAT
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acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A
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MetaCyc
fumigaclavine biosynthesis
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acetyl-CoA:fumigaclavine B O-acetyltransferase
The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family.
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acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
Substrates: -
Products: -
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acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
Substrates: -
Products: -
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acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
Substrates: -
Products: -
?
acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
Substrates: -
Products: -
?
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Ca2+
22% activation at 5 mM
additional information
no effects by Na+ and K+ at 5 mM, the acetyl-transfer reaction catalysed by FgaAT is very likely independent of the presence of metal ions
additional information
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no effects by Na+ and K+ at 5 mM, the acetyl-transfer reaction catalysed by FgaAT is very likely independent of the presence of metal ions
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0.122
acetyl-CoA
pH not specified in the publication, 37°C, recombinant His6-tagged enzyme
0.147
fumigaclavine B
pH not specified in the publication, 37°C, recombinant His6-tagged enzyme
additional information
additional information
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additional information
additional information
the FgaAT reaction apparently follows Michaelis-Menten kinetics
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additional information
additional information
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the FgaAT reaction apparently follows Michaelis-Menten kinetics
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0.6
acetyl-CoA
pH not specified in the publication, 37°C, recombinant His6-tagged enzyme
0.6
fumigaclavine B
pH not specified in the publication, 37°C, recombinant His6-tagged enzyme
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gene AFUA_2G18020
UniProt
brenda
gene AFUA_2G18020
UniProt
brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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physiological function
FgaAT catalyses the acetylation of fumigaclavine B, the conversion of fumigaclavine B to A, which belong to the ergot alkaloids of the clavine-type
physiological function
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FgaAT catalyses the acetylation of fumigaclavine B, the conversion of fumigaclavine B to A, which belong to the ergot alkaloids of the clavine-type
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EASN_ASPFU
Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)
494
0
55007
Swiss-Prot
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IFGH_PENRF
Penicillium roqueforti (strain FM164)
484
0
53739
Swiss-Prot
other Location (Reliability: 4)
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55000
1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
56700
1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
57000
1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
60800
recombinant His6-tagged enzyme, gel filtration
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monomer
1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
monomer
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1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
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gene AFUA_2G18020, DNA and amino acid seqquence determmination and analysis, sequence comparison, expression of His6-tagged FgaAT in Escherichia coli
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Liu, X.; Wang, L.; Steffan, N.; Yin, W.; Li, S.
Ergot alkaloid biosynthesis in Aspergillus fumigatus: FgaAT catalyses the acetylation of fumigaclavine B
ChemBioChem
10
2325-2328
2009
Aspergillus fumigatus (Q4WZ64), Aspergillus fumigatus, Aspergillus fumigatus Af293 (Q4WZ64)
brenda
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