Reference on EC 2.3.1.20 - diacylglycerol O-acyltransferase and Organism(s) Homo sapiens and UniProt Accession O75907
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kawasaki, T.; Snyder, F.
Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells [published erratum appears in J Biol Chem 1988 Jul 25;263(21):10539]
J. Biol. Chem.
263
2593-2596
1988
Homo sapiens
Cases, S.; Smith, S.J.; Zheng, Y.W.; Myers, H.M.; Lear, S.R.; Sande, E.; Novak, S.; Collins, C.; Welch, C.B.; Lusis, A.J.; Erickson, S.K.; Farese, R.V., Jr.
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
Proc. Natl. Acad. Sci. USA
95
13018-13023
1998
Homo sapiens, Mus musculus (Q9Z2A7), Mus musculus
Cases, S.; Stone, S.J.; Zhou, P.; Yen, E.; Tow, B.; Lardizabal, K.D.; Voelker, T.; Farese, R.V., Jr.
Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members
J. Biol. Chem.
276
38870-38876
2001
Homo sapiens (Q96PD7), Homo sapiens, Mus musculus (Q9DCV3), Mus musculus
Cheng, D.; Meegalla, R.L.; He, B.; Cromley, D.A.; Billheimer, J.T.; Young, P.R.
Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein
Biochem. J.
359
707-714
2001
Homo sapiens
Wakimoto, K.; Chiba, H.; Michibata, H.; Seishima, M.; Kawasaki, S.; Okubo, K.; Mitsui, H.; Torii, H.; Imai, Y.
A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice
Biochem. Biophys. Res. Commun.
310
296-302
2003
Homo sapiens, Mus musculus
Yen, C.L.; Brown Iv, C.H.; Monetti, M.; Farese, R.V., Jr.
A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters
J. Lipid Res.
46
2388-2397
2005
Homo sapiens
Orland, M.D.; Anwar, K.; Cromley, D.; Chu, C.; Chen, L.; Billheimer, J.T.; Hussain, M.M.; Cheng, D.
Acyl coenzyme A dependent retinol esterification by acyl coenzyme A:diacylglycerol acyltransferase 1
Biochim. Biophys. Acta
1737
76-82
2005
Homo sapiens
Turkish, A.R.; Henneberry, A.L.; Cromley, D.; Padamsee, M.; Oelkers, P.; Bazzi, H.; Christiano, A.M.; Billheimer, J.T.; Sturley, S.L.
Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily
J. Biol. Chem.
280
14755-14764
2005
Homo sapiens, Homo sapiens (Q6ZPD8), Homo sapiens (Q96PD7)
Chung, M.Y.; Rho, M.C.; Lee, S.W.; Park, H.R.; Kim, K.; Lee, I.A.; Kim, D.H.; Jeune, K.H.; Lee, H.S.; Kim, Y.K.
Inhibition of diacylglycerol acyltransferase by betulinic acid from Alnus hirsuta
Planta Med.
72
267-269
2006
Homo sapiens, Rattus norvegicus
Park, H.R.; Yoo, M.Y.; Seo, J.H.; Kim, I.S.; Kim, N.Y.; Kang, J.Y.; Cui, L.; Lee, C.S.; Lee, C.H.; Lee, H.S.
Sesquiterpenoids isolated from the flower buds of Tussilago farfara L. inhibit diacylglycerol acyltransferase
J. Agric. Food Chem.
56
10493-10497
2008
Homo sapiens, Rattus norvegicus
Inokoshi, J.; Kawamoto, K.; Takagi, Y.; Matsuhama, M.; Omura, S.; Tomoda, H.
Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes
J. Antibiot.
62
51-54
2009
Homo sapiens (O75907), Homo sapiens (Q96PD7), Homo sapiens
Cheng, D.; Iqbal, J.; Devenny, J.; Chu, C.H.; Chen, L.; Dong, J.; Seethala, R.; Keim, W.J.; Azzara, A.V.; Lawrence, R.M.; Pelleymounter, M.A.; Hussain, M.M.
Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption
J. Biol. Chem.
283
29802-29811
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Hou, X.G.; Moser, S.; Sarr, M.G.; Thompson, G.B.; Que, F.G.; Jensen, M.D.
Visceral and subcutaneous adipose tissue diacylglycerol acyltransferase activity in humans
Obesity (Silver Spring)
17
1129-1134
2009
Homo sapiens
Mougenot, P.; Namane, C.; Fett, E.; Camy, F.; Dadji-Faihun, R.; Langot, G.; Monseau, C.; Onofri, B.; Pacquet, F.; Pascal, C.; Crespin, O.; Ben-Hassine, M.; Ragot, J.L.; Van-Pham, T.; Philippo, C.; Chatelain-Egger, F.; Peron, P.; Le Bail, J.C.; Guillot, E.; Chamiot-Clerc, P.; Chabanaud, M.A.; Pruniaux, M.-P.; Schmidt, F.; Venier, O.; Nicolai, E.; Viviani, F.
Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1
Bioorg. Med. Chem. Lett.
22
2497-2502
2012
Homo sapiens
Wurie, H.R.; Buckett, L.; Zammit, V.A.
Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells
FEBS J.
279
3033-3047
2012
Homo sapiens (O75907), Homo sapiens (Q96PD7), Homo sapiens
Hiramine, Y.; Tanabe, T.
Characterization of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) enzyme of human small intestine
J. Physiol. Biochem.
67
259-264
2011
Homo sapiens
Kim, M.O.; Lee, S.; Choi, K.; Lee, S.; Kim, H.; Kang, H.; Choi, M.; Kwon, E.B.; Kang, M.J.; Kim, S.; Lee, H.J.; Lee, H.S.; Kwak, Y.S.; Cho, S.
Discovery of a novel class of diacylglycerol acyltransferase 2 inhibitors with a 1H-pyrrolo[2,3-b]pyridine core
Biol. Pharm. Bull.
37
1655-1660
2014
Homo sapiens
Nakajima, K.; April, M.; Brewer, J.T.; Daniels, T.; Forster, C.J.; Gilmore, T.A.; Jain, M.; Kanter, A.; Kwak, Y.; Li, J.; McQuire, L.; Serrano-Wu, M.H.; Streeper, R.; Szklennik, P.; Thompson, J.; Wang, B.
Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors
Bioorg. Med. Chem. Lett.
26
1245-1248
2016
Homo sapiens
Mougenot, P.; Namane, C.; Fett, E.; Goumy, F.; Dadji-Faihun, R.; Langot, G.; Monseau, C.; Onofri, B.; Pacquet, F.; Pascal, C.; Crespin, O.; Ben-Hassine, M.; Ragot, J.L.; Van-Pham, T.; Philippo, C.; Chatelain-Egger, F.; Peron, P.; Le Bail, J.C.; Guillot, E.; Chamiot-Clerc, P.; Chabanaud, M.A.; Pruniaux, M.-P.
Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors
Bioorg. Med. Chem. Lett.
26
25-32
2016
Homo sapiens
Jin, Y.; McFie, P.J.; Banman, S.L.; Brandt, C.; Stone, S.J.
Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesis
J. Biol. Chem.
289
28237-28248
2014
Homo sapiens
Seo, J.H.; Kim, M.O.; Han, A.R.; Kwon, E.B.; Kang, M.J.; Cho, S.; Moon, D.O.; Noh, J.R.; Lee, C.H.; Kim, Y.S.; Lee, H.S.
Oleanane-type triterpenoids of Aceriphyllum rossii and their diacylglycerol acyltransferase-inhibitory activity
Planta Med.
81
228-234
2015
Homo sapiens
Li, D.; Yin, J.; Li, J.; Nan, F.
Design and synthesis of diacylglycerol acyltransferase 1 inhibitors based on Aphadilactone C
Chinese J. Org. Chem.
36
1359-1367
2016
Homo sapiens (O75907)
-
Tschapalda, K.; Zhang, Y.Q.; Liu, L.; Golovnina, K.; Schlemper, T.; Eichmann, T.O.; Lal-Nag, M.; Sreenivasan, U.; McLenithan, J.; Ziegler, S.; Sztalryd, C.; Lass, A.; Auld, D.; Oliver, B.; Waldmann, H.; Li, Z.; Shen, M.; Boxer, M.B.; Beller, M.
A class of diacylglycerol acyltransferase 1 inhibitors identified by a combination of phenotypic high-throughput screening, genomics, and genetics
EBioMedicine
8
49-59
2016
Homo sapiens
Hong, D.J.; Jung, S.H.; Kim, J.; Jung, D.; Ahn, Y.G.; Suh, K.H.; Min, K.H.
Synthesis and biological evaluation of novel thienopyrimidine derivatives as diacylglycerol acyltransferase 1 (DGAT-1) inhibitors
J. Enzyme Inhib. Med. Chem.
35
227-234
2020
Canis lupus familiaris (E2RDN4), Canis lupus familiaris, Homo sapiens (O75907), Rattus norvegicus (Q9ERM3), Mus musculus (Q9Z2A7), Mus musculus
