Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for development of inhibitors of lipid deposition | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-[(4-chloro-3-fluorophenyl)methyl]-N-[2-(3,4-diethoxyphenyl)ethyl]-4H-thieno[3,2-b]pyrrole-5-carboxamide | EC value is 0.000009 mM | Homo sapiens | |
ethyl 1-(1-[[(2-chlorophenyl)carbamoyl]amino]cyclohexane-1-carbonyl)piperidine-4-carboxylate | EC value is 0.0015 mM | Homo sapiens | |
ethyl 1-[N-[(2,4-dichlorophenyl)carbamoyl]-2-methylalanyl]piperidine-4-carboxylate | EC value is 0.00025 mM | Homo sapiens | |
additional information | high-throughput screening for enzyme inhibitors, quantitative-high throughput image-based assay, overview. The activity of the identified lipid storage inhibitors is evolutionary conserved. Three scaffolds: structures are characterized by a tetrahydroindazole (CT1), thienopyrrole (CT2) or arylureido (CT3) core, phenotypic analysis of thienopyrrole (CT2) treated cells | Homo sapiens | |
N-[1-(3,5-dimethylphenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl]-1,2,3-thiadiazole-4-carboxamide | EC value is 0.10 mM | Homo sapiens | |
N-[1-(4-hydroxyphenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl]pyridine-2-carboxamide | EC value is 0.00000034 mM | Homo sapiens | |
N-[2-(3,4-diethoxyphenyl)ethyl]-4-methyl-4H-thieno[3,2-b]pyrrole-5-carboxamide | EC value is 0.011 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + 1,2-diacyl-sn-glycerol | Homo sapiens | - |
CoA + 1,2,3-triacylglycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + 1,2-diacyl-sn-glycerol | - |
Homo sapiens | CoA + 1,2,3-triacylglycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGAT1 | - |
Homo sapiens |
diacylglycerol acyltransferase 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | phenotypic analysis of thienopyrrole (CT2) inhibitor treated cells, overview | Homo sapiens |
physiological function | diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in the production of triacylglycerols | Homo sapiens |