Reference on EC 2.2.1.6 - acetolactate synthase and Organism(s) Mycobacterium tuberculosis and UniProt Accession O53554
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Choi, K.; Noh, K.M.; Choi, J.; Park, J.; Won, H.; Kim, J.; Kim, J.; Yoon, M.
Sulfonylurea is a non-competitive inhibitor of acetohydroxyacid synthase from Mycobacterium tuberculosis
Bull. Korean Chem. Soc.
27
1697-1700
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
-
Choi, K.J.; Yu, Y.G.; Hahn, H.G.; Choi, J.D.; Yoon, M.Y.
Characterization of acetohydroxyacid synthase from Mycobacterium tuberculosis and the identification of its new inhibitor from the screening of a chemical library
FEBS Lett.
579
4903-4910
2005
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Sohn, H.; Lee, K.S.; Ko, Y.K.; Ryu, J.W.; Woo, J.C.; Koo, D.W.; Shin, S.J.; Ahn, S.J.; Shin, A.R.; Song, C.H.; Jo, E.K.; Park, J.K.; Kim, H.J.
In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria
Int. J. Antimicrob. Agents
31
567-571
2008
Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium kansasii, Mycobacteroides abscessus
Choi, J.; Gedi, V.; Pham, C.; Ryu, K.; Lee, H.; Kim, G.; Yoon, M.
Site-directed mutagenesis of catalytic and regulatory subunits of Mycobacterium tuberculosis acetohydroxyacid synthase
Enzyme Microb. Technol.
46
304-308
2010
Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WG41), Mycobacterium tuberculosis H37Rv (P9WG41)
-
Singh, V.; Chandra, D.; Srivastava, B.S.; Srivastava, R.
Biochemical and transcription analysis of acetohydroxyacid synthase isoforms in Mycobacterium tuberculosis identifies these enzymes as potential targets for drug development
Microbiology
157
29-37
2011
Mycobacterium tuberculosis (O06335), Mycobacterium tuberculosis (O53554), Mycobacterium tuberculosis (P9WG39), Mycobacterium tuberculosis (P9WG41), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WG39), Mycobacterium tuberculosis H37Rv (P9WG41)
Gokhale, K.; Tilak, B.
Mechanisms of bacterial acetohydroxyacid synthase (AHAS) and specific inhibitors of Mycobacterium tuberculosis AHAS as potential drug candidates against tuberculosis
Curr. Drug Targets
16
689-699
2015
Saccharomyces cerevisiae, Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WG41 and P9WKJ3), Pseudomonas aeruginosa, Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli (P00892 and P0ADG1), Escherichia coli (P00893 and P00894), Escherichia coli (P08142 and P0ADF8), Mycobacterium tuberculosis H37Rv (P9WG41 and P9WKJ3)
Baig, I.A.; Gedi, V.; Lee, S.C.; Koh, S.H.; Yoon, M.Y.
Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase
Enzyme Microb. Technol.
53
243-249
2013
Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WG39), Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis H37Rv (P9WG39)
Baig, I.A.; Moon, J.Y.; Kim, M.S.; Koo, B.S.; Yoon, M.Y.
Structural and functional significance of the highly-conserved residues in Mycobacterium tuberculosis acetohydroxyacid synthase
Enzyme Microb. Technol.
58-59
52-59
2014
Mycobacterium tuberculosis (P9WG41), Mycobacterium tuberculosis H37Rv (P9WG41)
Baig, I.A.; Moon, J.Y.; Lee, S.C.; Ryoo, S.W.; Yoon, M.Y.
Development of ssDNA aptamers as potent inhibitors of Mycobacterium tuberculosis acetohydroxyacid synthase
Biochim. Biophys. Acta
1854
1338-1350
2015
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Lu, W.; Baig, I.A.; Sun, H.J.; Cui, C.J.; Guo, R.; Jung, I.P.; Wang, D.; Dong, M.; Yoon, M.Y.; Wang, J.G.
Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase
Eur. J. Med. Chem.
94
298-305
2015
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
