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Information on EC 2.1.1.53 - putrescine N-methyltransferase
for references in articles please use BRENDA:EC2.1.1.53
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EC Tree 2 Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.53 putrescine N-methyltransferase
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
- 2.1.1.53
- nicotine
-
tropane
- hyoscyamine
- n-methylputrescine
- scopolamine
- hyoscyamus
- atropa
- belladonna
- datura
- sylvestris
- tropinone
- stramonium
-
calystegines
-
meja-induced
-
anisodus
- tanguticus
- acutangulus
-
anatabine
-
jasmonate-inducible
-
4.1.1.19
-
jasmonate-responsive
- n-methyltransferases
- synthesis
- analysis
Reaction Schemes
showSynonyms
putrescine n-methyltransferase, ntpmt, putrescine methyltransferase, putrescine n-methyltransferase 1, putrescine n-methyltransferase i, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
methyltransferase, putrescine
-
-
-
-
PMT
PMT1
PMT2
PMT3
putrescine methyltransferase
-
-
-
-
putrescine N-methyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + putrescine = S-adenosyl-L-homocysteine + N-methylputrescine
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
1-methylpyrrolinium biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:putrescine N-methyltransferase
-
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CAS REGISTRY NUMBER
COMMENTARY
9075-39-2
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 1,4-diamino-2,3-dibromo-trans-but-2-ene
S-adenosyl-L-homocysteine + ?
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + 1,4-diamino-2-hydroxybutane
S-adenosyl-L-homocysteine + ?
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + 1,4-diamino-2-oxobutane
S-adenosyl-L-homocysteine + ?
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + 1,4-diamino-trans-but-2-ene
S-adenosyl-L-homocysteine + ?
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + 4-(aminomethyl)piperidine
S-adenosyl-L-homocysteine + ?
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + N-methylputrescine
S-adenosylhomocysteine + N,N-dimethylputrescine
-
Substrates: about 8% of activity compared to putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosylhomocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + trans-1,4-diamonocyclohexane
S-adenosyl-L-homocysteine + ?
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: best substrate
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: the enzyme has high affinity with putrescine but low catalytic activity, suggesting that it is a rate-limiting enzyme
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme possibly may play an additional, subtle role in alkaloid metabolsim in leaf tissue
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: requirement for substrate activity: two amino groups in a trans conformation, separated by four carbon atoms
Products: -
Products: -
?
additional information
?
-
-
Substrates: substrate with little activity: 1,4 -diamino-cis-but-2-ene, not: aliphatic monoamines, 1,3-diaminopropane, 1,5-diaminopentane, N,N`-dimethyl-1,4-diamino-trans-but-2-ene, 1,3-diamino-2-hydroxypropane, 1,3-diaminoacetone, 1,4-diaminobut-2-yne, N-carbamoylputrescine
Products: -
Products: -
?
additional information
?
-
Substrates: inactive with n-butylamine, 1,6-diaminohexane and 1,7-diaminoheptane, the PMT enzyme of potato appears to be specific for putrescine, it does not accept other mono-, di- or tri-amines
Products: -
Products: -
?
additional information
?
-
-
Substrates: inactive with n-butylamine, 1,6-diaminohexane and 1,7-diaminoheptane, the PMT enzyme of potato appears to be specific for putrescine, it does not accept other mono-, di- or tri-amines
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: the enzyme has high affinity with putrescine but low catalytic activity, suggesting that it is a rate-limiting enzyme
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme possibly may play an additional, subtle role in alkaloid metabolsim in leaf tissue
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme catalyzes the initial reaction in the biosynthesis of tropane and pyrrolidine alkaloids from putrescine
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: enzyme is probably involved in nicotine biosynthesis
Products: -
Products: -
?
S-adenosyl-L-methionine + putrescine
S-adenosyl-L-homocysteine + N-methylputrescine
-
Substrates: -
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
n-butylamine
strong inhibitor; strong inhibitor; strong inhibitor; strong inhibitor
N-methylputrescine
inhibitor with approximately competitive interaction kinetics to putrescine; inhibitor with approximately competitive interaction kinetics to putrescine
N-methylputrescine
inhibitor with approximately competitive interaction kinetics to putrescine
N-methylputrescine
inhibitor with approximately competitive interaction kinetics to putrescine; inhibitor with approximately competitive interaction kinetics to putrescine
N-methylputrescine
inhibitor with approximately competitive interaction kinetics to putrescine
N-methylputrescine
-
inhibitor with approximately competitive interaction kinetics to putrescine
N-methylputrescine
inhibitor with approximately competitive interaction kinetics to putrescine; inhibitor with approximately competitive interaction kinetics to putrescine
N-methylputrescine
inhibitor with approximately competitive interaction kinetics to putrescine
N-methylputrescine
inhibitor with approximately competitive interaction kinetics to putrescine
N-methylputrescine
inhibitor with approximately competitive interaction kinetics to putrescine
N-methylputrescine
-
inhibitor with approximately competitive interaction kinetics to putrescine
N-methylputrescine
inhibitor with approximately competitive interaction kinetics to putrescine; inhibitor with approximately competitive interaction kinetics to putrescine
N-methylputrescine
inhibitor with approximately competitive interaction kinetics to putrescine
N-methylputrescine