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Information on EC 2.1.1.4 - acetylserotonin O-methyltransferase and Organism(s) Mus musculus and UniProt Accession D3KU66

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.4 acetylserotonin O-methyltransferase
IUBMB Comments
Some other hydroxyindoles also act as acceptor, but more slowly.
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This record set is specific for:
Mus musculus
UNIPROT: D3KU66
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
hiomt, hydroxyindole-o-methyltransferase, hydroxyindole o-methyltransferase, n-acetylserotonin methyltransferase, acetylserotonin o-methyltransferase, n-acetylserotonin o-methyltransferase, hydroxyindole-o-methyl transferase, asmt2, acetylserotonin methyltransferase, asmt1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydroxyindole-O-methyltransferase
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acetylserotonin methyltransferase
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-
-
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ASMT
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-
-
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HIOMT
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-
-
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hydroxyindole methyltransferase
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-
-
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hydroxyindole O-methyltransferase
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hydroxyindole-O-methyl transferase
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methyltransferase, acetylserotonin
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-
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N-acetylserotonin O-methyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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O-methylation
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase
Some other hydroxyindoles also act as acceptor, but more slowly.
CAS REGISTRY NUMBER
COMMENTARY hide
9029-77-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + N-acetylserotonin
S-adenosyl-L-homocysteine + melatonin
show the reaction diagram
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-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0093 - 0.0098
S-adenosyl-L-methionine
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ASMT_MOUSE
387
0
40925
Swiss-Prot
Mitochondrion (Reliability: 4)
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
the standard radio-chemical assay is successful for pineal HIOMT only, whereas specific homogenization buffers and HPLC are required to detect retinal activity
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Betti, L.; Palego, L.; Demontis, G.C.; Miraglia, F.; Giannaccini, G.
Hydroxyindole-O-methyltransferase (HIOMT) activity in the retina of melatonin-proficient mice
Heliyon
5
e02417
2019
Mus musculus (D3KU66), Mus musculus
Manually annotated by BRENDA team