Ligand N-acetylserotonin

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Basic Ligand Information

Molecular Structure
Picture of N-acetylserotonin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C12H14N2O2
N-acetylserotonin
MVAWJSIDNICKHF-UHFFFAOYSA-N
Synonyms:
N-acetyl-5-hydroxytryptamine, N-acetyl-serotonin, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide


Show all pahtways known for Show all BRENDA pathways known for N-acetylserotonin

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + serotonin = CoA + N-acetylserotonin
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin
show the reaction diagram
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UDP-glucuronate + N-acetylserotonin = UDP + N-acetylserotonin beta-D-glucuronide
show the reaction diagram
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3'-phosphoadenylylsulfate + N-acetylserotonin = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
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N-Acetylserotonin + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + serotonin = CoA + N-acetylserotonin
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates, best at 0.1 mM
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Inhibitor in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
18% inhibition at 0.1 mM; 23% inhibition at 0.1 mM
-
IC50: 0.68 mM; very slightly
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1 mM inhibits synthesis of Nalpha-gamma-L-glutamylhistamine by 11%
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3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.3
-
pH 5.5, 37°C

KM Value (18 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.5
-
pH 5.5, 37°C
0.34
-
-

Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.042
-
-

IC50 Value (9 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.311
-
-
0.68
-
IC50: 0.68 mM
20
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IC50 above 20 mM, in the presence of 0.5 mM MnCl2, at 37°C

References & Links

Links to other databases for N-acetylserotonin

ChEBI
PubChem
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PubChem