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The enzyme from hops (Humulus lupulus) has a broad substrate specificity. The best substrates in vitro are resveratrol, desmethylxanthohumol, naringenin chalcone and isoliquiritigenin.
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The expected taxonomic range for this enzyme is: Humulus lupulus
OMT2, S-adenosyl-L-methionine-dependent O-methyltransferase, more
S-adenosyl-L-methionine + xanthohumol = S-adenosyl-L-homocysteine + 4-O-methylxanthohumol
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