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EC Tree
IUBMB Comments The enzyme from hops (Humulus lupulus) has a broad substrate specificity. The best substrates in vitro are resveratrol, desmethylxanthohumol, naringenin chalcone and isoliquiritigenin.
The expected taxonomic range for this enzyme is: Humulus lupulus
Synonyms
OMT2, S-adenosyl-L-methionine-dependent O-methyltransferase,
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S-adenosyl-L-methionine-dependent O-methyltransferase
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S-adenosyl-L-methionine + xanthohumol = S-adenosyl-L-homocysteine + 4-O-methylxanthohumol
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S-adenosyl-L-methionine:xanthohumol 4-O-methyltransferase
The enzyme from hops (Humulus lupulus) has a broad substrate specificity. The best substrates in vitro are resveratrol, desmethylxanthohumol, naringenin chalcone and isoliquiritigenin.
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S-adenosyl-L-methionine + 2',4-dihydroxychalcone
S-adenosyl-L-homocysteine + ?
45% of the activity with isoliquiritigenin
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-
?
S-adenosyl-L-methionine + butein
S-adenosyl-L-homocysteine + ?
50% of the activity with isoliquiritigenin
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-
?
S-adenosyl-L-methionine + chalconaringenin
S-adenosyl-L-homocysteine + ?
40% of the activity with isoliquiritigenin
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-
?
S-adenosyl-L-methionine + desmethylxanthohumol
S-adenosyl-L-homocysteine + 4'-O-methyl-desmethylxanthohumol
25% of the activity with isoliquiritigenin
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-
?
S-adenosyl-L-methionine + guaiacol
S-adenosyl-L-homocysteine + ?
42% of the activity with isoliquiritigenin
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?
S-adenosyl-L-methionine + isoliquiritigenin
S-adenosyl-L-homocysteine + ?
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?
S-adenosyl-L-methionine + resveratrol
S-adenosyl-L-homocysteine + ?
87% of the activity with isoliquiritigenin
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?
S-adenosyl-L-methionine + xanthohumol
S-adenosyl-L-homocysteine + 4'-O-methylxanthohumol
36% of the activity with isoliquiritigenin
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?
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additional information
bivalent cations (Mg2+, Fe2+, Zn2+, Cu2+, Ca2+, and Co2+) are not required for activity
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0.237
chalconaringenin
pH 7.5, 30°C
0.023
desmethylxanthohumol
pH 7.5, 30°C
0.019
resveratrol
pH 7.5, 30°C
0.034
S-adenosyl-L-methionine
pH 7.5, 30°C
0.031
xanthohumol
pH 7.5, 30°C
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UniProt
brenda
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OMT2_HUMLU
360
0
39792
Swiss-Prot
other Location (Reliability: 2 )
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dimer
2 * 39792, calculated
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Nagel, J.; Culley, L.; Lu, Y.; Liu, E.; Matthews, P.; Stevens, J.; Page, J.
EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol
Plant Cell
20
186-200
2008
Humulus lupulus (B0ZB56)
brenda
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2.1.1.339 xanthohumol 4-O-methyltransferase
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