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BRENDA support

Ligand xanthohumol

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Basic Ligand Information

Molecular Structure
Picture of xanthohumol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C21H22O5
xanthohumol
ORXQGKIUCDPEAJ-YRNVUSSQSA-N

Related pathways

Pathway Source
Pathways
MetaCyc
xanthohumol biosynthesis

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + xanthohumol = S-adenosyl-L-homocysteine + 4'-O-methylxanthohumol
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + desmethylxanthohumol = S-adenosyl-L-homocysteine + xanthohumol
show the reaction diagram
-
-
xanthohumol hydrate = xanthohumol + H2O
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
flavonoid isolated from hop, inhibits enzyme activity, no effect on enzyme expression
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
4.77
-
pH 6.0, 35°C, recombinant enzyme

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.031
-
pH 7.5, 30°C
0.98
-
pH 6.0, 35°C, recombinant enzyme

IC50 Value (4 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0203
-
pH not specified in the publication, temperature not specified in the publication
0.04
-
-

References & Links

Links to other databases for xanthohumol

EXTERNAL LINKS