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Information on EC 2.1.1.257 - tRNA (pseudouridine54-N1)-methyltransferase

for references in articles please use BRENDA:EC2.1.1.257

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IUBMB Comments

While this archaeal enzyme is specific for the 54 position and does not methylate pseudouridine at position 55, the presence of pseudouridine at position 55 is necessary for the efficient methylation of pseudouridine at position 54 [2,3].

The expected taxonomic range for this enzyme is: Archaea, Bacteria, Eukaryota

Synonyms
cog1901, hvo_1989, duf358/mj1640, mja_1640, pseudouridine n1-specific methyltransferase, duf358, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + pseudouridine54 in tRNA = S-adenosyl-L-homocysteine + N1-methylpseudouridine54 in tRNA
show the reaction diagram
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Highest Expressing Human Cell Lines
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