Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4'-hydroxyflavanone + S-adenosyl-L-methionine
4'-methoxyflavanone + S-adenosyl-L-homocysteine
-
Substrates: -
Products: -
?
apigenin + S-adenosyl-L-methionine
acacetin + S-adenosyl-L-homocysteine
-
Substrates: -
Products: -
?
genistein + S-adenosyl-L-methionine
biochanin A + S-adenosyl-L-homocysteine
-
Substrates: -
Products: -
?
kaempferol + S-adenosyl-L-methionine
kaempferide + S-adenosyl-L-homocysteine
-
Substrates: -
Products: -
?
S-adenosyl-L-methionine + 3'-O-methyleriodictyol
S-adenosyl-L-homocysteine + 3',4'-O-dimethyleriodictyol
S-adenosyl-L-methionine + alizarin
S-adenosyl-L-homocysteine + methylalizarin
Substrates: -
Products: -
?
S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + acacetin
-
Substrates: 36% of the activity relative to naringenin. Escherichia coli harboring SOMT-2 is grown with daidzein, geninstein, apigenin, naringenin, and quercetin, respectively, and reaction products were analyzed with thin layer chromatography and HPLC
Products: -
?
S-adenosyl-L-methionine + chrysoeriol
S-adenosyl-L-homocysteine + 4'-O-methylchrysoeriol
Substrates: -
Products: -
?
S-adenosyl-L-methionine + daidzein
S-adenosyl-L-homocysteine + formononetin
-
Substrates: 90% of the activity relative to naringenin. Escherichia coli harboring SOMT-2 is grown with daidzein, geninstein, apigenin, naringenin, and quercetin, respectively, and reaction products were analyzed with thin layer chromatography and HPLC
Products: -
?
S-adenosyl-L-methionine + eriodictyol
S-adenosyl-L-homocysteine + 4'-O-methyleriodictyol
Substrates: -
Products: -
?
S-adenosyl-L-methionine + fisetin
S-adenosyl-L-homocysteine + 4'-methoxyfisetin
Substrates: 8% activity with fisetin compared to quercetin
Products: -
?
S-adenosyl-L-methionine + genistein
S-adenosyl-L-homocysteine + biochanin A
-
Substrates: 62% of the activity relative to naringenin. Escherichia coli harboring SOMT-2 is grown with daidzein, geninstein, apigenin, naringenin, and quercetin, respectively, and reaction products were analyzed with thin layer chromatography and HPLC
Products: -
?
S-adenosyl-L-methionine + isorhamnetin
S-adenosyl-L-homocysteine + 4'-O-methylisorhamnetin
Substrates: -
Products: -
?
S-adenosyl-L-methionine + kaempferol
S-adenosyl-L-homocysteine + 4'-O-methylkaempferol
Substrates: -
Products: -
?
S-adenosyl-L-methionine + luteolin
S-adenosyl-L-homocysteine + 4'-methoxyluteolin
Substrates: 67% activity with luteolin compared to quercetin
Products: -
?
S-adenosyl-L-methionine + myricetin
S-adenosyl-L-homocysteine + 4'-methoxymyricetin
Substrates: 20% activity with luteolin compared to quercetin
Products: -
?
S-adenosyl-L-methionine + naringenin
S-adenosyl-L-homocysteine + ponciretin
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 4'-methoxyquercetin
Substrates: best substrate, 85% conversion at 2 mM substrate
Products: -
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 4'-methylquercetin
-
Substrates: Escherichia coli harboring SOMT-2 is grown with daidzein, geninstein, apigenin, naringenin, and quercetin, respectively, and reaction products were analyzed with thin layer chromatography and HPLC
Products: -
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + 4'-O-methylquercetin
Substrates: -
Products: -
?
S-adenosyl-L-methionine + quercetin
S-adenosyl-L-homocysteine + tamarixetin
Substrates: -
Products: -
?
S-adenosyl-L-methionine + quercetin 3-O-beta-D-glucoside
S-adenosyl-L-homocysteine + 4'-methoxyquercetin 3-O-beta-D-glucoside
Substrates: 16% activity with quercetin glucoside compared to quercetin
Products: -
?
additional information
?
-
S-adenosyl-L-methionine + 3'-O-methyleriodictyol
S-adenosyl-L-homocysteine + 3',4'-O-dimethyleriodictyol
Substrates: -
Products: -
?
S-adenosyl-L-methionine + 3'-O-methyleriodictyol
S-adenosyl-L-homocysteine + 3',4'-O-dimethyleriodictyol
Substrates: -
Products: product identification by mass spectrometry
?
S-adenosyl-L-methionine + naringenin
S-adenosyl-L-homocysteine + ponciretin
-
Substrates: i.e. 4',5,7-trihyroxyflavanone. Escherichia coli harboring SOMT-2 is grown with daidzein, geninstein, apigenin, naringenin, and quercetin, respectively, and reaction products were analyzed with thin layer chromatography and HPLC
Products: i.e. 4'-methoxy-5,7-dihydroxyflavanone
?
S-adenosyl-L-methionine + naringenin
S-adenosyl-L-homocysteine + ponciretin
Substrates: i.e. 4',5,7-trihyroxyflavanone, the enzyme transfers a methyl group to 4'-hydroxyl group of naringenin
Products: i.e. 4'-methoxy-5,7-dihydroxyflavanone
?
S-adenosyl-L-methionine + naringenin
S-adenosyl-L-homocysteine + ponciretin
Substrates: i.e. 4',5,7-trihyroxyflavanone, reaction of SOMT-2
Products: i.e. 4'-methoxy-5,7-dihydroxyflavanone
?
additional information
?
-
Substrates: the only substrates found for CrOMT6 are 3'-O-methyl-eriodictyol (homoeriodictyol) and the corresponding flavones and flavonols, substrate specificty, overview. No or poor activity with naringenin, pentahydroxyflavanone, hesperetin, myricetin, 7,3'-O-dimethylquercetin, 7-O-methylquercetin, syringetin, apigenin, luteolin, tricetin, velutin, dihydrokaempferol, dihydroquercetin, dihydromyricetin, and 3'-O-methyl-dihydroquercetin, and also no activity with ferulic acid, coniferyl alcohol, vanillic acid vanillin, eugenol, isoeugenol, and guaicol. Not only the B-ring configuration, but also the size and shape of the A-ring are critical parts of the substrate specificity
Products: -
?
additional information
?
-
-
Substrates: the only substrates found for CrOMT6 are 3'-O-methyl-eriodictyol (homoeriodictyol) and the corresponding flavones and flavonols, substrate specificty, overview. No or poor activity with naringenin, pentahydroxyflavanone, hesperetin, myricetin, 7,3'-O-dimethylquercetin, 7-O-methylquercetin, syringetin, apigenin, luteolin, tricetin, velutin, dihydrokaempferol, dihydroquercetin, dihydromyricetin, and 3'-O-methyl-dihydroquercetin, and also no activity with ferulic acid, coniferyl alcohol, vanillic acid vanillin, eugenol, isoeugenol, and guaicol. Not only the B-ring configuration, but also the size and shape of the A-ring are critical parts of the substrate specificity
Products: -
?
additional information
?
-
-
Substrates: enzyme specifically methylates the hydroxy substituent in 4'-position of the flavones, flavanones and isoflavones in the presence of S-adenosyl-L-methionine. No activity towards hydroxycinnamic acid derivatives
Products: -
?
additional information
?
-
-
Substrates: SOMT-2 has a regiospecific methylation activity, resulting in transforming 4'-hydroxyl group of flavonoids B-ring to 4'-methyl group. Caffeic acid, catechol, ferulic acid, and oricinol are biotransformed at less than 1%
Products: -
?
additional information
?
-
Substrates: among the flavonoids, quercetin is the most favorable substrate, followed by luteolin, myricetin, quercetin glucoside, and fisetin, while only a single product is formed in each case. Product identification by mass-spectrometry and NMR spectrometric analysis. Susbtrate specificity, overview. Mechanistic overview of the regiospecific modification, a double bond between the C2 and the C3 and a single-ring-appended conjugate-hydroxyl group are crucial for the favorable enzymatic conversions of the GerMIII catalysis, modeling and molecular docking. Of all of the anthraquinones that are tested, only alizarin is methylated by the GerMIII at a detectable amount, whereas the methylation of all of the other remaining compounds is not evident. The common feature among the GerMIII substrates is the existence of two neighboring hydroxyl groups in the presence of a double bond between the C2 and the C3, as found in the quercetin, luteolin, myricetin, fisetin, and quercetin glucoside. GerMIII does not methylate many substrates including the close flavonoid relative catechin, which lacks the double bond between the C2 and the C3
Products: -
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Curir, P.; Lanzotti, V.; Dolci, M.; Dolci, P.; Pasini, C.; Tollin, G.
Purification and properties of a new S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase from carnation (Dianthus caryophyllus L.)
Eur. J. Biochem.
270
3422-3431
2003
Dianthus caryophyllus
brenda
Schroeder, G.; Wehinger, E.; Lukacin, R.; Wellmann, F.; Seefelder, W.; Schwab, W.; Schroeder, J.
Flavonoid methylation: a novel 4'-O-methyltransferase from Catharanthus roseus, and evidence that partially methylated flavanones are substrates of four different flavonoid dioxygenases
Phytochemistry
65
1085-1094
2004
Catharanthus roseus (Q6VCW3), Catharanthus roseus
brenda
Kim, D.H.; Kim, B.G.; Lee, Y.; Ryu, J.Y.; Lim, Y.; Hur, H.G.; Ahn, J.H.
Regiospecific methylation of naringenin to ponciretin by soybean O-methyltransferase expressed in Escherichia coli
J. Biotechnol.
119
155-162
2005
Glycine max
brenda
Kim, B.G.; Shin, K.H.; Lee, Y.; Hur, H.G.; Lim, Y.; Ahn, J.H.
Multiple regiospecific methylations of a flavonoid by plant O-methyltransferases expressed in E. coli
Biotechnol. Lett.
27
1861-1864
2005
Glycine max
brenda
Kim, M.; Kim, B.; Ahn, J.
Biosynthesis of bioactive O-methylated flavonoids in Escherichia coli
Appl. Microbiol. Biotechnol.
97
7195-7204
2013
Glycine max (C6TAY1)
brenda
Darsandhari, S.; Dhakal, D.; Shrestha, B.; Parajuli, P.; Seo, J.H.; Kim, T.S.; Sohng, J.K.
Characterization of regioselective flavonoid O-methyltransferase from the Streptomyces sp. KCTC 0041BP
Enzyme Microb. Technol.
113
29-36
2018
Streptomyces sp. KCTC 0041BP (Q331Q6)
brenda